{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Silent+Stroke",
    "query": {
      "condition": "Silent Stroke"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T12:15:53.358Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04698031",
      "title": "Efficacy of Clopidogrel on Incidence of Silent Brain Infarction",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Silent Brain Infarction"
      ],
      "interventions": [
        {
          "name": "Clopidogrel treatment",
          "type": "DRUG"
        },
        {
          "name": "Aspirin treatment",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "21 Years to 90 Years"
      },
      "enrollment_count": 134,
      "start_date": "2022-03-30",
      "completion_date": "2026-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-01-29",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04698031"
    },
    {
      "nct_id": "NCT00072761",
      "title": "Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Sickle Cell Anemia",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "transfusion therapy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "14 Years",
        "sex": "ALL",
        "summary": "5 Years to 14 Years"
      },
      "enrollment_count": 196,
      "start_date": "2004-12",
      "completion_date": "2013-12",
      "has_results": true,
      "last_update_posted_date": "2016-02-08",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00072761"
    },
    {
      "nct_id": "NCT01389024",
      "title": "Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Sickle Cell Disease",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Hydroxyurea",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Months",
        "maximum_age": "54 Months",
        "sex": "ALL",
        "summary": "12 Months to 54 Months"
      },
      "enrollment_count": 28,
      "start_date": "2012-08-16",
      "completion_date": "2022-05-24",
      "has_results": true,
      "last_update_posted_date": "2024-07-10",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 5,
      "location_summary": "Birmingham, Alabama • Baltimore, Maryland • Kansas City, Missouri + 2 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01389024"
    },
    {
      "nct_id": "NCT05984056",
      "title": "Multidisciplinary Lifestyle Interventions for Neurological Disorders During the Silent Phase",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neurological Disorder"
      ],
      "interventions": [
        {
          "name": "Multidisciplinary lifestyle interventions",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Vineet Punia MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2023-07-13",
      "completion_date": "2036-06",
      "has_results": false,
      "last_update_posted_date": "2026-07-10",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05984056"
    },
    {
      "nct_id": "NCT06763549",
      "title": "COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiopulmonary Failure",
        "Myocardial Infarction (MI)",
        "Heart Decompensation",
        "Heart Failure",
        "HFrEF - Heart Failure with Reduced Ejection Fraction",
        "HFpEF - Heart Failure with Preserved Ejection Fraction",
        "Syncopation",
        "Syncope",
        "Ischemic Cardiovascular Disease",
        "STEMI",
        "STEMI (ST Elevation MI)",
        "Atrial Fibrillation (AF)",
        "Atrial Enlargement",
        "LVF",
        "Conduction Defect",
        "Conduction Abnormalities",
        "Heart Block",
        "Valvular Diseases",
        "Cardiac Output, Low",
        "Stroke Volume",
        "Stroke Volume Variation",
        "Hyperkalemia",
        "Hypercalcemia",
        "Hypocalcemia",
        "LV Dysfunction",
        "QT Prolongation",
        "Sudden Cardiac Death Due to Cardiac Arrhythmia",
        "Ventricular Arrhythmia",
        "Pacing",
        "Pacing Induced Dyssynchrony",
        "Silent Ischemia",
        "Pericarditis",
        "Sleep Related Breathing Disorder",
        "RSA",
        "Apnea, Obstructive",
        "Cardiac Output Measurement",
        "Respiratory Impedance",
        "CRT And/or ICD",
        "Infarction",
        "Cardiomyopathies, Primary",
        "Hypertrophy"
      ],
      "interventions": [
        {
          "name": "SUBPROTOCOL A",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL B",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL C",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL D",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL E",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL F",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL G",
          "type": "DEVICE"
        },
        {
          "name": "SUBPROTOCOL H",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Peerbridge Health, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15000,
      "start_date": "2024-11-16",
      "completion_date": "2026-04-15",
      "has_results": false,
      "last_update_posted_date": "2025-01-08",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06763549"
    },
    {
      "nct_id": "NCT03376893",
      "title": "Epidemiology of Silent and Overt Strokes in Sickle Cell Disease",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Anemia, Sickle Cell",
        "Sickle Cell Disease",
        "Stroke",
        "Sickle Cell Thalassemia",
        "Sickle Cell-Beta0-Thalassemia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 102,
      "start_date": "2017-06-02",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 4,
      "location_summary": "Birmingham, Alabama • St Louis, Missouri • Nashville, Tennessee",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03376893"
    },
    {
      "nct_id": "NCT00739869",
      "title": "Evaluating the Effects of Hormone Replacement Therapy on Brain Function (The WHIMS-MRI Study)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "90 Years",
        "sex": "FEMALE",
        "summary": "65 Years to 90 Years · Female only"
      },
      "enrollment_count": 1426,
      "start_date": "2004-05",
      "completion_date": "2007-03",
      "has_results": false,
      "last_update_posted_date": "2024-05-06",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00739869"
    },
    {
      "nct_id": "NCT04808778",
      "title": "Stroke Prevention in Young Adults With Sickle Cell Anemia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sickle Cell Disease",
        "Sickle Cell Anemia",
        "Stroke, Ischemic",
        "Silent Stroke",
        "Silent Cerebral Infarct",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Hydroxyurea therapy per standard care",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "16 Years to 26 Years"
      },
      "enrollment_count": 250,
      "start_date": "2021-05-17",
      "completion_date": "2029-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-05",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04808778"
    },
    {
      "nct_id": "NCT00015717",
      "title": "Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Ischemia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 24,
      "start_date": "2001-04",
      "completion_date": "2004-03",
      "has_results": false,
      "last_update_posted_date": "2008-03-04",
      "last_synced_at": "2026-07-22T12:15:53.358Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00015717"
    }
  ]
}