{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Skin+Barrier+Dysfunction",
    "query": {
      "condition": "Skin Barrier Dysfunction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T12:06:10.046Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03728569",
      "title": "Skin Barrier Dysfunction and the Role of Skin Barrier Restoration",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Cutaneous Inflammation"
      ],
      "interventions": [
        {
          "name": "Vanicream Moisturizing Skin Cream",
          "type": "OTHER"
        },
        {
          "name": "Vanicream Cleansing Soap",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 14,
      "start_date": "2018-05-16",
      "completion_date": "2021-02-01",
      "has_results": false,
      "last_update_posted_date": "2021-05-06",
      "last_synced_at": "2026-09-06T12:06:10.046Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03728569"
    },
    {
      "nct_id": "NCT07645820",
      "title": "Evaluation of a Non-Invasive Device for Early Detection of Atopic Dermatitis Flares",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Atopic Dermatitis"
      ],
      "interventions": [
        {
          "name": "Nevisense electrical impedance spectroscopy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Castle Biosciences Incorporated",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "12 Years to 89 Years"
      },
      "enrollment_count": 450,
      "start_date": "2026-05-29",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-12",
      "last_synced_at": "2026-09-06T12:06:10.046Z",
      "location_count": 4,
      "location_summary": "Phoenix, Arizona • Las Vegas, Nevada • Portsmouth, New Hampshire + 1 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Portsmouth",
          "state": "New Hampshire"
        },
        {
          "city": "Missouri City",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07645820"
    },
    {
      "nct_id": "NCT07725835",
      "title": "Effect of FPP on Cutaneous Barrier Integrity",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Barrier Dysfunction",
        "Healthy Volunteers"
      ],
      "interventions": [
        {
          "name": "Fermented Papaya Preparation (FPP)",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "50 Years to 75 Years"
      },
      "enrollment_count": 30,
      "start_date": "2026-09",
      "completion_date": "2028-07",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-06T12:06:10.046Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07725835"
    },
    {
      "nct_id": "NCT07271381",
      "title": "THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Allergic",
        "Inflammatory"
      ],
      "interventions": [
        {
          "name": "Environmental Exposures",
          "type": "OTHER"
        },
        {
          "name": "Control Exposures",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 120,
      "start_date": "2026-04-15",
      "completion_date": "2031-01-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-10",
      "last_synced_at": "2026-09-06T12:06:10.046Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07271381"
    },
    {
      "nct_id": "NCT03089476",
      "title": "Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Atopic Dermatitis",
        "Eczema",
        "Food Allergy"
      ],
      "interventions": [
        {
          "name": "Evaluating atopy in infants",
          "type": "OTHER"
        },
        {
          "name": "Evaluating TEWL and STS in adults",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "National Jewish Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "34 Weeks",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "34 Weeks to 50 Years"
      },
      "enrollment_count": 0,
      "start_date": "2017-09-30",
      "completion_date": "2018-07-30",
      "has_results": false,
      "last_update_posted_date": "2018-06-12",
      "last_synced_at": "2026-09-06T12:06:10.046Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03089476"
    }
  ]
}