{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Small+Vessel+Ischemic+Disease",
    "query": {
      "condition": "Small Vessel Ischemic Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 35,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Small+Vessel+Ischemic+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T13:22:09.623Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05567744",
      "title": "Registry for CADASIL",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebral Autosomal Dominant Ateriopathy With Subcortical Infarcts and Leukoencephalopathy"
      ],
      "interventions": [
        {
          "name": "Registry",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 2500,
      "start_date": "2022-06-03",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2025-10-16",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05567744"
    },
    {
      "nct_id": "NCT04876040",
      "title": "Incorporating Supersaturated Oxygen in Shock",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiogenic Shock",
        "STEMI"
      ],
      "interventions": [
        {
          "name": "SSO2 Downstream System",
          "type": "DEVICE"
        },
        {
          "name": "PCI + Impella",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "TherOx",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2021-12-17",
      "completion_date": "2025-06",
      "has_results": false,
      "last_update_posted_date": "2024-01-24",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 7,
      "location_summary": "Miami, Florida • Springfield, Massachusetts • Detroit, Michigan + 4 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Massachusetts"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        },
        {
          "city": "Allentown",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04876040"
    },
    {
      "nct_id": "NCT04975464",
      "title": "BRINK (BRain In Kidney Disease) Memory Study 2.0",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Kidney Diseases",
        "Dementia",
        "Dementia, Vascular",
        "Stroke",
        "Alzheimer Disease",
        "Cognitive Decline",
        "Cognitive Impairment",
        "Cognitive Dysfunction",
        "Kidney Diseases",
        "Diabetes",
        "Cerebral Atrophy",
        "Small Vessel Ischemic Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Anne Murray",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 600,
      "start_date": "2011-11-15",
      "completion_date": "2026-05",
      "has_results": false,
      "last_update_posted_date": "2025-11-04",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 2,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04975464"
    },
    {
      "nct_id": "NCT05677880",
      "title": "Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "CADASIL"
      ],
      "interventions": [
        {
          "name": "Study Procedures",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 660,
      "start_date": "2022-06-03",
      "completion_date": "2027-08",
      "has_results": false,
      "last_update_posted_date": "2026-01-15",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 12,
      "location_summary": "Los Angeles, California • San Francisco, California • Denver, Colorado + 9 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05677880"
    },
    {
      "nct_id": "NCT02795052",
      "title": "Neurologic Stem Cell Treatment Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neurologic Disorders",
        "Nervous System Diseases",
        "Neurodegenerative Diseases",
        "Neurological Disorders",
        "Stroke",
        "Traumatic Brain Injury",
        "Cadasil",
        "Chronic Traumatic Encephalopathy",
        "Cerebral Infarction",
        "Cerebral Ischemia",
        "Cerebral Stroke",
        "Cerebral Hemorrhage",
        "Parkinson",
        "Multi-System Degeneration",
        "MSA - Multiple System Atrophy",
        "Progressive Supranuclear Palsy",
        "ALS",
        "Amyotrophic Lateral Sclerosis",
        "Neuropathy",
        "Diabetic Neuropathies",
        "Alzheimer Disease",
        "Dementia",
        "Frontotemporal Dementia",
        "Lewy Body Disease",
        "Cognitive Impairment",
        "Lewy Body Variant of Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "Intravenous and Intranasal BMSC",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "MD Stem Cells",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2016-06",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2025-06-06",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 2,
      "location_summary": "Westport, Connecticut • Coral Springs, Florida",
      "locations": [
        {
          "city": "Westport",
          "state": "Connecticut"
        },
        {
          "city": "Coral Springs",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02795052"
    },
    {
      "nct_id": "NCT00371748",
      "title": "A Study of the TAXUS Liberté Stent for the Treatment of de Novo Coronary Artery Lesions in Small Vessels",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "TAXUS Liberté-SR",
          "type": "DEVICE"
        },
        {
          "name": "TAXUS™ Express2",
          "type": "DEVICE"
        },
        {
          "name": "Express2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Scientific Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 261,
      "start_date": "2005-02",
      "completion_date": "2011-04",
      "has_results": false,
      "last_update_posted_date": "2012-02-02",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 19,
      "location_summary": "Sacramento, California • Newark, Delaware • Orlando, Florida + 16 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00371748"
    },
    {
      "nct_id": "NCT05491980",
      "title": "Florida Cerebrovascular Disease Biorepository and Genomics Center",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebrovascular Disease",
        "Ischemic Stroke",
        "Transient Ischemic Attack",
        "Intracerebral Hemorrhage",
        "Aneurysmal Subarachnoid Hemorrhage",
        "Vascular Dementia",
        "Anoxic Brain Injury",
        "Unruptured Intracranial Aneurysm",
        "Carotid Artery Stenosis Symptomatic",
        "Asymptomatic Carotid Artery Stenosis",
        "Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage",
        "Cerebral Venous Thrombosis",
        "Moyamoya Disease",
        "Fibromuscular Dysplasia",
        "Subarachnoid Hemorrhage",
        "Leukoaraiosis",
        "Arteriovenous Fistula",
        "Reversible Cerebral Vasoconstriction Syndrome",
        "CADASIL"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2022-08-02",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05491980"
    },
    {
      "nct_id": "NCT05971446",
      "title": "Healthy Little Eyes",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy",
        "Neonatal Encephalopathy",
        "Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Visual Evoked Potential (VEP)",
          "type": "DEVICE"
        },
        {
          "name": "Electroretinogram (ERG)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "36 Months",
        "sex": "ALL",
        "summary": "Up to 36 Months"
      },
      "enrollment_count": 125,
      "start_date": "2020-02-24",
      "completion_date": "2029-07",
      "has_results": false,
      "last_update_posted_date": "2026-05-14",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05971446"
    },
    {
      "nct_id": "NCT05035823",
      "title": "COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neurologic Disorder",
        "Paralysis",
        "Paralysis; Stroke",
        "Amyotrophic Lateral Sclerosis",
        "Muscular Dystrophies",
        "Spinal Cord Injuries",
        "Stroke, Lacunar",
        "Stroke Brainstem",
        "Cervical Spinal Cord Injury",
        "Spinal Muscular Atrophy",
        "Tetraplegic; Paralysis",
        "Quadriplegia/Tetraplegia"
      ],
      "interventions": [
        {
          "name": "Motor Neuroprosthesis (MNP)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Synchron Medical, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 6,
      "start_date": "2022-04-27",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2025-04-29",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 3,
      "location_summary": "Buffalo, New York • New York, New York • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05035823"
    },
    {
      "nct_id": "NCT00489541",
      "title": "TAXUS PERSEUS Small Vessel",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "Percutaneous Coronary Intervention (PCI) with paclitaxel-eluting stent (TAXUS Element) implantation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Scientific Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 224,
      "start_date": "2007-07",
      "completion_date": "2013-10",
      "has_results": true,
      "last_update_posted_date": "2014-05-08",
      "last_synced_at": "2026-06-07T13:22:09.623Z",
      "location_count": 28,
      "location_summary": "Birmingham, Alabama • Bakersfield, California • La Jolla, California + 24 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Bakersfield",
          "state": "California"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Ocala",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00489541"
    }
  ]
}