{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Smith-Magenis+Syndrome",
    "query": {
      "condition": "Smith-Magenis Syndrome"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 13,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Smith-Magenis+Syndrome&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:46:57.360Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01906866",
      "title": "Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Sleep Disorders"
      ],
      "interventions": [
        {
          "name": "Circadin 2/5/10 mg",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Neurim Pharmaceuticals Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 125,
      "start_date": "2013-10",
      "completion_date": "2018-03-27",
      "has_results": true,
      "last_update_posted_date": "2024-04-23",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 18,
      "location_summary": "Phoenix, Arizona • Miami Lakes, Florida • Orange City, Florida + 14 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Miami Lakes",
          "state": "Florida"
        },
        {
          "city": "Orange City",
          "state": "Florida"
        },
        {
          "city": "West Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Smyrna",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01906866"
    },
    {
      "nct_id": "NCT02231008",
      "title": "Evaluating the Effects of Tasimelteon vs Placebo on Sleep Disturbances in SMS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Smith-Magenis Syndrome",
        "Circadian"
      ],
      "interventions": [
        {
          "name": "tasimelteon",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanda Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "3 Years to 65 Years"
      },
      "enrollment_count": 49,
      "start_date": "2015-09",
      "completion_date": "2022-01",
      "has_results": false,
      "last_update_posted_date": "2022-11-18",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 4,
      "location_summary": "Santa Monica, California • Baltimore, Maryland • Chevy Chase, Maryland + 1 more",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Chevy Chase",
          "state": "Maryland"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02231008"
    },
    {
      "nct_id": "NCT02776215",
      "title": "Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Circadian Rhythm Sleep Disorders",
        "Non-24 Hour Sleep-Wake Disorder",
        "Autism Spectrum Disorder",
        "Smith-Magenis Syndrome"
      ],
      "interventions": [
        {
          "name": "tasimelteon",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanda Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "3 Years to 17 Years"
      },
      "enrollment_count": 24,
      "start_date": "2016-10-04",
      "completion_date": "2017-12-20",
      "has_results": false,
      "last_update_posted_date": "2024-03-21",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02776215"
    },
    {
      "nct_id": "NCT02180451",
      "title": "Observational Study to Investigate the Melatonin and Cortisol Circadian Rhythms of Individuals With Smith-Magenis Syndrome (SMS)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Smith Magenis Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Vanda Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "6 Years to 50 Years"
      },
      "enrollment_count": 8,
      "start_date": "2014-06",
      "completion_date": "2017-01",
      "has_results": false,
      "last_update_posted_date": "2016-03-25",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02180451"
    },
    {
      "nct_id": "NCT00506259",
      "title": "Treatment Strategies for Children With Smith-Magenis Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Developmental Delay Disorders",
        "Chromosome Deletion",
        "Mental Retardation",
        "Sleep Disorders, Circadian Rhythm",
        "Self Injurious Behavior"
      ],
      "interventions": [
        {
          "name": "dTR Melatonin (NIH CC PDS)",
          "type": "DRUG"
        },
        {
          "name": "Phototherapy (Bright Light)",
          "type": "DEVICE"
        },
        {
          "name": "Melatonin CR",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "3 Years to 45 Years"
      },
      "enrollment_count": 23,
      "start_date": "2007-07-17",
      "completion_date": "2018-05-22",
      "has_results": false,
      "last_update_posted_date": "2019-12-12",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00506259"
    },
    {
      "nct_id": "NCT00013559",
      "title": "Natural History Study of Smith-Magenis Syndrome",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Smith-Magenis Syndrome (SMS)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "115 Years",
        "sex": "ALL",
        "summary": "1 Month to 115 Years"
      },
      "enrollment_count": 593,
      "start_date": "2001-03-19",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00013559"
    },
    {
      "nct_id": "NCT06274164",
      "title": "Clinical and Molecular Biomarker Studies in RAI1 (Retinoic Acid-Induced 1) -Related Disorders",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "RAI1 Gene 17P11.2 Deletion+Duplication"
      ],
      "interventions": [
        {
          "name": "Electroencephalography/Polysomnography (EEG/PSG)",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Skin Biopsy",
          "type": "PROCEDURE"
        },
        {
          "name": "Blood draw",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "PROCEDURE"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "1 Month to 80 Years"
      },
      "enrollment_count": 90,
      "start_date": "2024-03-13",
      "completion_date": "2027-03",
      "has_results": false,
      "last_update_posted_date": "2025-05-25",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06274164"
    },
    {
      "nct_id": "NCT03013543",
      "title": "Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Genetic Obesity",
        "Obesity",
        "Obesity Due to Melanocortin 4 Receptor Deficiency"
      ],
      "interventions": [
        {
          "name": "Setmelanotide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rhythm Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Years and older"
      },
      "enrollment_count": 213,
      "start_date": "2017-02-10",
      "completion_date": "2022-03-01",
      "has_results": true,
      "last_update_posted_date": "2023-08-18",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 43,
      "location_summary": "Birmingham, Alabama • Chandler, Arizona • Mesa, Arizona + 37 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03013543"
    },
    {
      "nct_id": "NCT00004351",
      "title": "Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Williams Syndrome",
        "Angelman Syndrome",
        "Prader-Willi Syndrome",
        "Shprintzen Syndrome",
        "Smith-Magenis Syndrome",
        "DiGeorge Syndrome",
        "Chromosome Abnormalities"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "0 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "1999-09",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2005-06-24",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00004351"
    },
    {
      "nct_id": "NCT03154697",
      "title": "Development of Clinical Database of Individuals With Smith-Magenis Syndrome and Sleep Disturbances",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Sleep Disturbances in Smith-Magenis Syndrome"
      ],
      "interventions": [
        {
          "name": "Data collection of sleep disturbances in individuals with SMS",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Vanda Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "3 Years to 65 Years"
      },
      "enrollment_count": 1000,
      "start_date": "2016-01",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2024-03-20",
      "last_synced_at": "2026-05-22T09:46:57.360Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03154697"
    }
  ]
}