{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sodium+Retention",
    "query": {
      "condition": "Sodium Retention"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 12,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sodium+Retention&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T16:47:10.343Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04752293",
      "title": "Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hypertension",
        "Left Ventricular Hypertrophy",
        "Left Ventricular Dysfunction",
        "Left Atrial Dilatation",
        "Left Ventricular Diastolic Dysfunction",
        "Kidney Diseases",
        "Kidney Injury",
        "Kidney Dysfunction",
        "Sodium Urine High",
        "Blood Pressure Disorders",
        "Uric Acid Retention",
        "Angiotensin Hypertension",
        "Autonomic Dysfunction",
        "Autonomic Imbalance",
        "Pediatric Kidney Disease",
        "Pediatric Obesity",
        "Proteinuria",
        "Albuminuria"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "7 Years to 18 Years"
      },
      "enrollment_count": 125,
      "start_date": "2021-05-19",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-11",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04752293"
    },
    {
      "nct_id": "NCT04233957",
      "title": "Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sodium Excess"
      ],
      "interventions": [
        {
          "name": "High Sodium",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of Delaware",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "21 Years to 45 Years"
      },
      "enrollment_count": 50,
      "start_date": "2020-01-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-11-29",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Newark, Delaware",
      "locations": [
        {
          "city": "Newark",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04233957"
    },
    {
      "nct_id": "NCT01617798",
      "title": "Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure",
        "Volume Overload",
        "Hypernatremia"
      ],
      "interventions": [
        {
          "name": "Supplemental metolazone diuresis",
          "type": "DRUG"
        },
        {
          "name": "Placebo Comparator: Control-- furosemide (lasix) only",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 0,
      "start_date": "2012-06",
      "completion_date": "2013-06",
      "has_results": false,
      "last_update_posted_date": "2019-06-06",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01617798"
    },
    {
      "nct_id": "NCT01564238",
      "title": "Effect of Sodium Intake on Calcium Retention in Girls",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoporosis"
      ],
      "interventions": [
        {
          "name": "Low Na diet (1.3 g/d)",
          "type": "OTHER"
        },
        {
          "name": "High sodium diet (3.8 g/d)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Purdue University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "15 Years",
        "sex": "FEMALE",
        "summary": "11 Years to 15 Years · Female only"
      },
      "enrollment_count": 67,
      "start_date": "1999-01",
      "completion_date": "2000-08",
      "has_results": false,
      "last_update_posted_date": "2018-05-09",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "West Lafayette, Indiana",
      "locations": [
        {
          "city": "West Lafayette",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01564238"
    },
    {
      "nct_id": "NCT06995144",
      "title": "Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Heart Failure",
        "Edema",
        "Pulmonary Congestion",
        "Fluid Overload"
      ],
      "interventions": [
        {
          "name": "Extended Release Torsemide Tablets",
          "type": "DRUG"
        },
        {
          "name": "Immedate Release Torsemide Tablets",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sarfez Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2025-05-28",
      "completion_date": "2025-12-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-10",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06995144"
    },
    {
      "nct_id": "NCT05111392",
      "title": "Hydration Dynamics and Influence of Beverage Composition",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hydration",
        "Fluid Retention",
        "Dehydration"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Oral Rehydration Solution 1",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Oral Rehydration Solution 2",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 14,
      "start_date": "2021-09-03",
      "completion_date": "2022-11-30",
      "has_results": false,
      "last_update_posted_date": "2023-07-14",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05111392"
    },
    {
      "nct_id": "NCT05092854",
      "title": "The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Retention",
        "Sodium Retention",
        "Heat Stress",
        "Dehydration (Physiology)",
        "Renal Injury",
        "Electrolyte and Fluid Balance Conditions"
      ],
      "interventions": [
        {
          "name": "PR Lotion - AMP Human Performance",
          "type": "OTHER"
        },
        {
          "name": "Placebo Lotion",
          "type": "OTHER"
        },
        {
          "name": "AminoVital - Rapid Recovery",
          "type": "OTHER"
        },
        {
          "name": "Placebo Supplement",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Connecticut",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "18 Years to 45 Years · Male only"
      },
      "enrollment_count": 18,
      "start_date": "2021-09-03",
      "completion_date": "2022-08-01",
      "has_results": false,
      "last_update_posted_date": "2022-10-24",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Storrs, Connecticut",
      "locations": [
        {
          "city": "Storrs",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05092854"
    },
    {
      "nct_id": "NCT05591612",
      "title": "Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Nutrition",
        "Culinary Medicine",
        "Sodium Excess"
      ],
      "interventions": [
        {
          "name": "Salt replacement seasoning (50% salt and 50% MSG) mix",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Salt replacement seasoning (70% salt and 30% MSG) mix",
          "type": "BEHAVIORAL"
        },
        {
          "name": "NaCl (sodium chloride/table salt)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Texas Tech University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 148,
      "start_date": "2023-02-10",
      "completion_date": "2023-11-15",
      "has_results": false,
      "last_update_posted_date": "2024-08-01",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Lubbock, Texas",
      "locations": [
        {
          "city": "Lubbock",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05591612"
    },
    {
      "nct_id": "NCT04598386",
      "title": "The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Fluid Retention",
        "Fluid Loss",
        "Sodium Retention",
        "Cognitive Change",
        "Heat Exposure",
        "Hyperhydration",
        "Electrolyte and Fluid Balance Conditions"
      ],
      "interventions": [
        {
          "name": "PR Lotion - AMP Human Performance",
          "type": "OTHER"
        },
        {
          "name": "Placebo Lotion",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Connecticut",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "MALE",
        "summary": "18 Years to 35 Years · Male only"
      },
      "enrollment_count": 20,
      "start_date": "2020-12-09",
      "completion_date": "2021-04-09",
      "has_results": false,
      "last_update_posted_date": "2021-10-14",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Storrs, Connecticut",
      "locations": [
        {
          "city": "Storrs",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04598386"
    },
    {
      "nct_id": "NCT01219179",
      "title": "Use of Sterile Water Feeds for Treatment of Hypernatremia in Extremely Low Birth Weight Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Extremely Low Birth Weight Infants",
        "Hypernatremia"
      ],
      "interventions": [
        {
          "name": "Sterile water feedings",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Hours",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "24 Hours to 28 Weeks"
      },
      "enrollment_count": 19,
      "start_date": "2010-11",
      "completion_date": "2012-08",
      "has_results": false,
      "last_update_posted_date": "2013-02-27",
      "last_synced_at": "2026-07-22T16:47:10.343Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01219179"
    }
  ]
}