{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Sperm+DNA+Fragmentation",
    "query": {
      "condition": "Sperm DNA Fragmentation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T00:07:34.561Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02268123",
      "title": "Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Male Infertility"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Reproductive Medicine Associates of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "35 Years to 40 Years"
      },
      "enrollment_count": 323,
      "start_date": "2014-10",
      "completion_date": "2018-07",
      "has_results": false,
      "last_update_posted_date": "2018-09-11",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 2,
      "location_summary": "Basking Ridge, New Jersey • Allentown, Pennsylvania",
      "locations": [
        {
          "city": "Basking Ridge",
          "state": "New Jersey"
        },
        {
          "city": "Allentown",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02268123"
    },
    {
      "nct_id": "NCT06629766",
      "title": "The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infertility (IVF Patients)",
        "Oocyte Competence",
        "Sperm DNA Fragmentation",
        "Paternal Age",
        "Sperm Selection"
      ],
      "interventions": [
        {
          "name": "Microfluidic sperm separation device",
          "type": "DEVICE"
        },
        {
          "name": "Density grade centrifugation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Reproductive Medicine Associates of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "41 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 41 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2025-04-09",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-04-17",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "Basking Ridge, New Jersey",
      "locations": [
        {
          "city": "Basking Ridge",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06629766"
    },
    {
      "nct_id": "NCT03829943",
      "title": "Vitamin D and Human Sperm DNA Fragmentation",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Infertility,Male",
        "Vitamin D Deficiency"
      ],
      "interventions": [
        {
          "name": "Vitamin D",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Sanford Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "56 Years",
        "sex": "MALE",
        "summary": "21 Years to 56 Years · Male only"
      },
      "enrollment_count": 230,
      "start_date": "2019-03-21",
      "completion_date": "2022-02",
      "has_results": false,
      "last_update_posted_date": "2020-10-12",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "Sioux Falls, South Dakota",
      "locations": [
        {
          "city": "Sioux Falls",
          "state": "South Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03829943"
    },
    {
      "nct_id": "NCT03527043",
      "title": "Impact of Escitalopram on Sperm DNA Fragmentation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Sperm DNA Fragmentation",
        "Infertility, Male"
      ],
      "interventions": [
        {
          "name": "Escitalopram",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "MALE",
        "summary": "18 Years to 65 Years · Male only"
      },
      "enrollment_count": 75,
      "start_date": "2017-10-01",
      "completion_date": "2024-05-31",
      "has_results": true,
      "last_update_posted_date": "2025-08-06",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03527043"
    },
    {
      "nct_id": "NCT03483298",
      "title": "Split Cohort Trial Comparing IVF Outcomes After the Use of Testicular vs. Ejaculated Sperm for ICSI",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Infertility"
      ],
      "interventions": [
        {
          "name": "ICSI",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Reproductive Medicine Associates of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "MALE",
        "summary": "18 Years to 65 Years · Male only"
      },
      "enrollment_count": 7,
      "start_date": "2018-06-23",
      "completion_date": "2021-12-31",
      "has_results": false,
      "last_update_posted_date": "2022-01-28",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "Basking Ridge, New Jersey",
      "locations": [
        {
          "city": "Basking Ridge",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03483298"
    },
    {
      "nct_id": "NCT07311928",
      "title": "HELIOS: Human Embryo Illumination to Enhance Development",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "IVF Outcomes"
      ],
      "interventions": [
        {
          "name": "Photobiomodulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "48 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 48 Years · Female only"
      },
      "enrollment_count": 200,
      "start_date": "2025-12-03",
      "completion_date": "2028-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-25",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07311928"
    },
    {
      "nct_id": "NCT03646825",
      "title": "Effect of Natural Antioxidant Supplement on Sperm DNA Fragmentation",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Observe Effect of Antioxidant on Sperm DNA Fragmention"
      ],
      "interventions": [
        {
          "name": "Natural Antioxidant supplement",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Colorado Center for Reproductive Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "MALE",
        "summary": "18 Years to 55 Years · Male only"
      },
      "enrollment_count": 54,
      "start_date": "2018-08-01",
      "completion_date": "2022-10-01",
      "has_results": false,
      "last_update_posted_date": "2023-02-23",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "Lone Tree, Colorado",
      "locations": [
        {
          "city": "Lone Tree",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03646825"
    },
    {
      "nct_id": "NCT06990841",
      "title": "Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "DNA Damage",
        "DNA Strand Breaks",
        "Sperm DNA Fragmentation"
      ],
      "interventions": [
        {
          "name": "sperm separation device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Richard Kordus, PhD, HCLD (ABB)",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "34 Years",
        "sex": "ALL",
        "summary": "18 Years to 34 Years"
      },
      "enrollment_count": 50,
      "start_date": "2025-08-11",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-09-17",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "Greenville, South Carolina",
      "locations": [
        {
          "city": "Greenville",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06990841"
    },
    {
      "nct_id": "NCT03085433",
      "title": "Sperm Selection by Microfluidic Separation Improves Embryo Quality",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sperm DNA Fragmentation",
        "Embryo Quality",
        "Fertility Disorders",
        "Infertility",
        "Infertility, Male",
        "Infertility Unexplained"
      ],
      "interventions": [
        {
          "name": "Microfluidic Sperm Sorting",
          "type": "DEVICE"
        },
        {
          "name": "in vitro fertilization",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 393,
      "start_date": "2017-06-20",
      "completion_date": "2022-04-30",
      "has_results": true,
      "last_update_posted_date": "2025-12-31",
      "last_synced_at": "2026-05-22T00:07:34.561Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03085433"
    }
  ]
}