{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Abuse+Problem",
    "query": {
      "condition": "Substance Abuse Problem"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 505,
    "total_pages": 51,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Abuse+Problem&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T13:13:09.384Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00944554",
      "title": "Relapse Prevention With Varenicline",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Recurrence",
        "Smoking Cessation",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 104,
      "start_date": "2008-10",
      "completion_date": "2011-05",
      "has_results": true,
      "last_update_posted_date": "2017-08-03",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00944554"
    },
    {
      "nct_id": "NCT00985595",
      "title": "Learning Effective Approaches to Prevention",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Adolescent Substance Abuse"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "The National Center on Addiction and Substance Abuse at Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "13 Years to 17 Years"
      },
      "enrollment_count": 200,
      "start_date": "2006-01",
      "completion_date": "2012-03",
      "has_results": false,
      "last_update_posted_date": "2015-08-05",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00985595"
    },
    {
      "nct_id": "NCT00227903",
      "title": "Therapeutic Substance Abuse Treatment in Pregnancy - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Alcohol Abuse",
        "Cocaine Abuse",
        "Marijuana Abuse"
      ],
      "interventions": [
        {
          "name": "MI-CBT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Brief Advice",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 45 Years · Female only"
      },
      "enrollment_count": 168,
      "start_date": "2004-09",
      "completion_date": "2010-08",
      "has_results": true,
      "last_update_posted_date": "2020-04-15",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 2,
      "location_summary": "Bridgeport, Connecticut • New Haven, Connecticut",
      "locations": [
        {
          "city": "Bridgeport",
          "state": "Connecticut"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00227903"
    },
    {
      "nct_id": "NCT06612788",
      "title": "Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Use Disorder"
      ],
      "interventions": [
        {
          "name": "Exablate Model 4000 Type 2.0/2.1",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "West Virginia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 5,
      "start_date": "2023-09-19",
      "completion_date": "2025-04-25",
      "has_results": false,
      "last_update_posted_date": "2025-07-20",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "Morgantown, West Virginia",
      "locations": [
        {
          "city": "Morgantown",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06612788"
    },
    {
      "nct_id": "NCT01327586",
      "title": "Abstinence-Linked Money Management Multisite",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dual Diagnosis",
        "Cocaine Abuse",
        "Cocaine Dependence",
        "Polysubstance Abuse"
      ],
      "interventions": [
        {
          "name": "ATM",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Individual Drug Counseling",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 108,
      "start_date": "2009-12",
      "completion_date": "2014-01",
      "has_results": false,
      "last_update_posted_date": "2020-03-30",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 2,
      "location_summary": "Bridgeport, Connecticut • Hartford, Connecticut",
      "locations": [
        {
          "city": "Bridgeport",
          "state": "Connecticut"
        },
        {
          "city": "Hartford",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01327586"
    },
    {
      "nct_id": "NCT06743282",
      "title": "Senyo Health With Substance Use Disorder (SUD) in Primary Care",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use Disorders",
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "Senyo App",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Follow-up",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2025-09-22",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 2,
      "location_summary": "Scottsdale, Arizona • Rochester, Minnesota",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06743282"
    },
    {
      "nct_id": "NCT00373750",
      "title": "Cradling Our Future Through Family Strengthening Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Abuse",
        "Post-partum Depression",
        "Depression"
      ],
      "interventions": [
        {
          "name": "Family Spirit Intervention",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Johns Hopkins Bloomberg School of Public Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "19 Years",
        "sex": "FEMALE",
        "summary": "12 Years to 19 Years · Female only"
      },
      "enrollment_count": 322,
      "start_date": "2006-06",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2015-01-12",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 5,
      "location_summary": "Fort Defiance, Arizona • San Carlos, Arizona • Tuba City, Arizona + 2 more",
      "locations": [
        {
          "city": "Fort Defiance",
          "state": "Arizona"
        },
        {
          "city": "San Carlos",
          "state": "Arizona"
        },
        {
          "city": "Tuba City",
          "state": "Arizona"
        },
        {
          "city": "Whiteriver",
          "state": "Arizona"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00373750"
    },
    {
      "nct_id": "NCT02677025",
      "title": "Young Women's Health CoOp (Cooperative) in Cape Town",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "HIV",
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "Young Women's Health CoOp (YWHC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "HIV Counseling/Testing",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "RTI International",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "21 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 21 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2014-05",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2025-01-08",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "Research Triangle Park, North Carolina",
      "locations": [
        {
          "city": "Research Triangle Park",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02677025"
    },
    {
      "nct_id": "NCT00249717",
      "title": "Group-Based Contingency Management for Substance Abuse Treatment - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "Contingency management",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 312,
      "start_date": "2005-05",
      "completion_date": "2010-01",
      "has_results": false,
      "last_update_posted_date": "2011-11-21",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "Farmington, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00249717"
    },
    {
      "nct_id": "NCT03249350",
      "title": "Enhancing Adolescent Substance Abuse Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "Standard Contingency Management (CM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Enhanced Contingency Management (CM+)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Oregon Social Learning Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 129,
      "start_date": "2018-04-23",
      "completion_date": "2024-07-31",
      "has_results": true,
      "last_update_posted_date": "2025-11-14",
      "last_synced_at": "2026-07-22T13:13:09.384Z",
      "location_count": 1,
      "location_summary": "Eugene, Oregon",
      "locations": [
        {
          "city": "Eugene",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03249350"
    }
  ]
}