{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Misuse&page=2",
    "query": {
      "condition": "Substance Misuse",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Misuse&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T11:25:13.584Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04134767",
      "title": "Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use",
        "HIV Infections",
        "HCV Infection",
        "Sexually Transmitted Infections (Not HIV or Hepatitis)",
        "Overdose, Drug",
        "Opioid Use"
      ],
      "interventions": [
        {
          "name": "Health Linkage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Overdose Education",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "April M Young",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 234,
      "start_date": "2019-11-15",
      "completion_date": "2022-10-27",
      "has_results": true,
      "last_update_posted_date": "2023-12-21",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04134767"
    },
    {
      "nct_id": "NCT05333341",
      "title": "Pain Care at Home to Amplify Function (Pain CHAMP)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Use Disorder",
        "Opioid Misuse",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "TCM",
          "type": "BEHAVIORAL"
        },
        {
          "name": "TCM plus COPES",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 259,
      "start_date": "2023-06-16",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-30",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 3,
      "location_summary": "Little Rock, Arkansas • Aurora, Colorado • West Haven, Connecticut",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "West Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05333341"
    },
    {
      "nct_id": "NCT06880705",
      "title": "The Trans-Led Care Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Abuse",
        "Substance Addiction",
        "Substance Use Disorder (SUD)",
        "Substance Use (Drugs, Alcohol)",
        "Human Immunodeficiency Virus (HIV)"
      ],
      "interventions": [
        {
          "name": "The TLC Program",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Illinois Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 124,
      "start_date": "2026-04-14",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-15",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06880705"
    },
    {
      "nct_id": "NCT02464410",
      "title": "Primary Care Intervention to Reduce Prescription Opioid Overdoses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain",
        "Drug Overdose",
        "Opioid Use Disorders"
      ],
      "interventions": [
        {
          "name": "Motivational intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Psycho-educational control",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Long-term opioid therapy informed consent",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 299,
      "start_date": "2016-08-04",
      "completion_date": "2021-03-31",
      "has_results": true,
      "last_update_posted_date": "2023-07-27",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02464410"
    },
    {
      "nct_id": "NCT05169281",
      "title": "Distribution of Medication Disposal Packets - Acute Opioid Prescribing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthopedic Surgery",
        "Neurosurgery",
        "Surgery",
        "Opioid Use",
        "Opioid Misuse"
      ],
      "interventions": [
        {
          "name": "Medication Disposal Packet",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 657,
      "start_date": "2021-03-24",
      "completion_date": "2021-05-26",
      "has_results": false,
      "last_update_posted_date": "2023-06-02",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05169281"
    },
    {
      "nct_id": "NCT01292577",
      "title": "Adapted Cognitive/Affective Remediation for Cannabis Misuse in Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Schizophrenia",
        "Schizoaffective Disorder"
      ],
      "interventions": [
        {
          "name": "CET/PT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment as Usual",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 33,
      "start_date": "2010-09",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2020-04-13",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01292577"
    },
    {
      "nct_id": "NCT03495245",
      "title": "Identification of Potential Biomarkers for Pain",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Fibromyalgia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Rowan University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2018-03-28",
      "completion_date": "2021-09-30",
      "has_results": false,
      "last_update_posted_date": "2019-11-19",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Stratford, New Jersey",
      "locations": [
        {
          "city": "Stratford",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03495245"
    },
    {
      "nct_id": "NCT01829308",
      "title": "SBIRT Implementation for Adolescents in Urban Federally Qualified Health Centers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol-induced Disorders",
        "Drug Users",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "The brief interventions are delivered by behavioral health counselors (Specialist)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "The brief interventions are delivered by the primary care provider (Generalist)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Friends Research Institute, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 98,
      "start_date": "2013-04",
      "completion_date": "2017-12-31",
      "has_results": false,
      "last_update_posted_date": "2018-02-14",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01829308"
    },
    {
      "nct_id": "NCT04839978",
      "title": "Community Trial in the Cherokee Nation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid Abuse"
      ],
      "interventions": [
        {
          "name": "Connect Program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Communities Mobilizing for Change and Action (CMCA)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "15 Years to 17 Years"
      },
      "enrollment_count": 919,
      "start_date": "2021-09-29",
      "completion_date": "2024-12-31",
      "has_results": true,
      "last_update_posted_date": "2026-03-05",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Tahlequah, Oklahoma",
      "locations": [
        {
          "city": "Tahlequah",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04839978"
    },
    {
      "nct_id": "NCT03416751",
      "title": "Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cirrhosis",
        "Alcohol Abuse"
      ],
      "interventions": [
        {
          "name": "Fecal Microbial Transplant",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "Hunter Holmes Mcguire Veteran Affairs Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2018-02-01",
      "completion_date": "2020-04-10",
      "has_results": false,
      "last_update_posted_date": "2020-07-28",
      "last_synced_at": "2026-07-24T11:25:13.584Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03416751"
    }
  ]
}