{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Use",
    "query": {
      "condition": "Substance Use"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 3226,
    "total_pages": 323,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substance+Use&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T14:39:08.978Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06413797",
      "title": "Little Cigar and Cigarillo Warnings for Youth",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Little Cigars and Cigarillos (LCC) Use"
      ],
      "interventions": [
        {
          "name": "FDA warnings + Image",
          "type": "BEHAVIORAL"
        },
        {
          "name": "FDA Warnings Text-Only",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Surgeon General Text-Only Warnings",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "UNC Lineberger Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "15 Years to 20 Years"
      },
      "enrollment_count": 928,
      "start_date": "2024-07-18",
      "completion_date": "2024-11-25",
      "has_results": true,
      "last_update_posted_date": "2025-12-24",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06413797"
    },
    {
      "nct_id": "NCT03112369",
      "title": "Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "HIV Prevention",
        "PTSD and Substance Use Disorder"
      ],
      "interventions": [
        {
          "name": "Narrative Exposure Therapy (NET)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Motivational Interviewing w/Skills Training (MIST)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 125,
      "start_date": "2017-09-21",
      "completion_date": "2024-08-30",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03112369"
    },
    {
      "nct_id": "NCT05957159",
      "title": "Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Alcohol Use Disorder"
      ],
      "interventions": [
        {
          "name": "Detoxification Program",
          "type": "OTHER"
        },
        {
          "name": "PKAB",
          "type": "RADIATION"
        },
        {
          "name": "CFN",
          "type": "RADIATION"
        }
      ],
      "intervention_types": [
        "OTHER",
        "RADIATION"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 100,
      "start_date": "2023-11-07",
      "completion_date": "2028-11-01",
      "has_results": false,
      "last_update_posted_date": "2025-04-01",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05957159"
    },
    {
      "nct_id": "NCT04393623",
      "title": "Stress, Emotion Regulation, and Alcohol in Women Veterans",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol Use Disorder",
        "Post Traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Cognitive Reappraisal",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Psychoeducation",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 81,
      "start_date": "2020-11-01",
      "completion_date": "2024-09-30",
      "has_results": true,
      "last_update_posted_date": "2026-02-27",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Leeds, Massachusetts",
      "locations": [
        {
          "city": "Leeds",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04393623"
    },
    {
      "nct_id": "NCT03592186",
      "title": "Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use",
        "Adolescent Behavior"
      ],
      "interventions": [
        {
          "name": "Parenting Wisely+",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment as Usual",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "12 Years to 17 Years"
      },
      "enrollment_count": 122,
      "start_date": "2017-04-01",
      "completion_date": "2020-02-28",
      "has_results": true,
      "last_update_posted_date": "2022-01-21",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 2,
      "location_summary": "Rockford, Illinois • Cranston, Rhode Island",
      "locations": [
        {
          "city": "Rockford",
          "state": "Illinois"
        },
        {
          "city": "Cranston",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03592186"
    },
    {
      "nct_id": "NCT04015869",
      "title": "Effect of Allopregnanolone on Stress-induced Craving",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Alcohol Use Disorder"
      ],
      "interventions": [
        {
          "name": "Allopregnanolone",
          "type": "DRUG"
        },
        {
          "name": "Placebos",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-07-01",
      "completion_date": "2023-09-01",
      "has_results": true,
      "last_update_posted_date": "2025-08-22",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "West Haven, Connecticut",
      "locations": [
        {
          "city": "West Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04015869"
    },
    {
      "nct_id": "NCT06538922",
      "title": "Developing a Digital Intervention to Prevent Risky Health Behaviors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Substance Use"
      ],
      "interventions": [
        {
          "name": "Single Session Family Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "14 Years",
        "sex": "ALL",
        "summary": "12 Years to 14 Years"
      },
      "enrollment_count": 9,
      "start_date": "2024-07-29",
      "completion_date": "2024-12-05",
      "has_results": false,
      "last_update_posted_date": "2024-12-10",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06538922"
    },
    {
      "nct_id": "NCT01010620",
      "title": "Screening Protocol for Research Participants",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Schizophrenia",
        "Substance Abuse",
        "Cocaine Abuse",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Various Screening psychiatric and medical assessments",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Maryland, Baltimore",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 523,
      "start_date": "2009-12",
      "completion_date": "2019-06-01",
      "has_results": false,
      "last_update_posted_date": "2019-08-19",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Catonsville, Maryland",
      "locations": [
        {
          "city": "Catonsville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01010620"
    },
    {
      "nct_id": "NCT01122186",
      "title": "Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men (ACE)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "HIV Medication Adherence",
        "Methamphetamine Use",
        "Sexual Risk",
        "Poly-substance Use",
        "HIV Infections"
      ],
      "interventions": [
        {
          "name": "Motivational Interviewing + Cognitive Behavioral Skills Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Education Attention Control",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Hunter College of City University of New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "18 Years and older · Male only"
      },
      "enrollment_count": 210,
      "start_date": "2007-09",
      "completion_date": "2012-01",
      "has_results": false,
      "last_update_posted_date": "2013-06-03",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01122186"
    },
    {
      "nct_id": "NCT05143073",
      "title": "Understanding Genetic Risk for Alcohol Use Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol Use Disorder"
      ],
      "interventions": [
        {
          "name": "Alcohol use disorder and strategies to reduce risk educational material",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 338,
      "start_date": "2021-11-15",
      "completion_date": "2021-12-13",
      "has_results": false,
      "last_update_posted_date": "2022-01-19",
      "last_synced_at": "2026-06-07T14:39:08.978Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05143073"
    }
  ]
}