{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substrate+Metabolism&page=2",
    "query": {
      "condition": "Substrate Metabolism",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Substrate+Metabolism&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T21:37:37.280Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07298863",
      "title": "The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hydration Status",
        "Substrate Metabolism During Exercise"
      ],
      "interventions": [
        {
          "name": "Exercise Trial",
          "type": "OTHER"
        },
        {
          "name": "Experimental Trial",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "PepsiCo Global R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 74,
      "start_date": "2025-11-05",
      "completion_date": "2026-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-03",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Valhalla, New York",
      "locations": [
        {
          "city": "Valhalla",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07298863"
    },
    {
      "nct_id": "NCT01240252",
      "title": "Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Type 2 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Human insulin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "30 Years to 65 Years"
      },
      "enrollment_count": 14,
      "start_date": "2012-03",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2013-06-05",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Scottsdale, Arizona",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01240252"
    },
    {
      "nct_id": "NCT06537401",
      "title": "Metabolic Adaptations to High-fat Diet",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adiposity",
        "Insulin Sensitivity",
        "Impaired Glucose Tolerance",
        "Metabolic Disturbance"
      ],
      "interventions": [
        {
          "name": "Hypercaloric, High Fat Diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "George Washington University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "20 Years to 45 Years"
      },
      "enrollment_count": 2,
      "start_date": "2024-08-12",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-26",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06537401"
    },
    {
      "nct_id": "NCT00526071",
      "title": "Open-label Long-term Safety Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease Who Have Completed a Previous AT1001 Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Fabry Disease"
      ],
      "interventions": [
        {
          "name": "migalastat HCl",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Amicus Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2007-09-17",
      "completion_date": "2012-09-08",
      "has_results": true,
      "last_update_posted_date": "2018-10-03",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 3,
      "location_summary": "Decatur, Georgia • New York, New York • Dallas, Texas",
      "locations": [
        {
          "city": "Decatur",
          "state": "Georgia"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00526071"
    },
    {
      "nct_id": "NCT05282355",
      "title": "Astaxanthin Reduces Exercising Heart Rate.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Metabolic Flexibility"
      ],
      "interventions": [
        {
          "name": "Astaxanthin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of North Alabama",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 19,
      "start_date": "2021-05-12",
      "completion_date": "2021-07-02",
      "has_results": false,
      "last_update_posted_date": "2022-03-16",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Florence, Alabama",
      "locations": [
        {
          "city": "Florence",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05282355"
    },
    {
      "nct_id": "NCT00714220",
      "title": "Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Amyotrophic Lateral Sclerosis",
        "Neurodegenerative Diseases"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Drexel University College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "20 Years to 85 Years"
      },
      "enrollment_count": 107,
      "start_date": "2006-11",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2015-10-29",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00714220"
    },
    {
      "nct_id": "NCT04168372",
      "title": "Fructose: Substrate, Stimulus, or Both?",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Insulin Resistance",
        "Insulin Sensitivity",
        "Pre Diabetes"
      ],
      "interventions": [
        {
          "name": "High fructose, fructose labeled meal",
          "type": "OTHER"
        },
        {
          "name": "High fructose, pyruvate labeled meal",
          "type": "OTHER"
        },
        {
          "name": "Low fructose, fructose labeled meal",
          "type": "OTHER"
        },
        {
          "name": "Low fructose, pyruvate labeled meal",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Touro University, California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "20 Years to 55 Years"
      },
      "enrollment_count": 35,
      "start_date": "2019-09-15",
      "completion_date": "2026-12-20",
      "has_results": false,
      "last_update_posted_date": "2026-04-24",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Vallejo, California",
      "locations": [
        {
          "city": "Vallejo",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04168372"
    },
    {
      "nct_id": "NCT04819308",
      "title": "Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Obesity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Arkansas Children's Hospital Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "11 Years",
        "sex": "ALL",
        "summary": "8 Years to 11 Years"
      },
      "enrollment_count": 95,
      "start_date": "2021-03-18",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2025-02-25",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04819308"
    },
    {
      "nct_id": "NCT06242015",
      "title": "Ordered Eating and Acute Exercise",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Glucose Metabolism Disorders",
        "Hunger"
      ],
      "interventions": [
        {
          "name": "Carbohydrate-first meal",
          "type": "OTHER"
        },
        {
          "name": "Carbohydrate-last meal",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Old Dominion University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 23,
      "start_date": "2024-02-06",
      "completion_date": "2024-07-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-01",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Norfolk, Virginia",
      "locations": [
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06242015"
    },
    {
      "nct_id": "NCT06252922",
      "title": "Diet-Induced Changes in GEnetic Material",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diet, Healthy",
        "Body Weight",
        "Metabolic Disturbance"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Pennington Biomedical Research Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "35 Years",
        "sex": "MALE",
        "summary": "20 Years to 35 Years · Male only"
      },
      "enrollment_count": 10,
      "start_date": "2023-11-11",
      "completion_date": "2026-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-05-31",
      "last_synced_at": "2026-06-26T21:37:37.280Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06252922"
    }
  ]
}