{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Symptomatic+Non-Obstructive+Hypertrophic+Cardiomyopathy", "query": { "condition": "Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 9, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-23T14:34:52.691Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04848506", "title": "Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Symptomatic Hypertrophic Cardiomyopathy (HCM)" ], "interventions": [ { "name": "Aficamten (5 - 20 mg)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cytokinetics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 900, "start_date": "2021-05-06", "completion_date": "2028-03", "has_results": false, "last_update_posted_date": "2026-01-22", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 52, "location_summary": "Birmingham, Alabama • Anchorage, Alaska • Phoenix, Arizona + 39 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Anchorage", "state": "Alaska" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04848506" }, { "nct_id": "NCT06481891", "title": "A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Obstructive Cardiomyopathy, Hypertrophic", "Non-obstructive Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "Sotagliflozin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lexicon Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 500, "start_date": "2024-09-24", "completion_date": "2026-08", "has_results": false, "last_update_posted_date": "2026-05-18", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 33, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Los Angeles, California + 28 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Pomona", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06481891" }, { "nct_id": "NCT03442764", "title": "A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Non-obstructive Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "mavacamten", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "MyoKardia, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 59, "start_date": "2018-03-30", "completion_date": "2020-01-07", "has_results": true, "last_update_posted_date": "2022-08-09", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 32, "location_summary": "Scottsdale, Arizona • Los Angeles, California • Palo Alto, California + 28 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03442764" }, { "nct_id": "NCT04219826", "title": "Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertrophic Cardiomyopathy (HCM)" ], "interventions": [ { "name": "CK-3773274 (5 - 15 mg)", "type": "DRUG" }, { "name": "CK-3773274 (10 - 30 mg)", "type": "DRUG" }, { "name": "Placebo for CK-3773274", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cytokinetics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 96, "start_date": "2020-01-10", "completion_date": "2023-02-28", "has_results": true, "last_update_posted_date": "2026-02-24", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 18, "location_summary": "Los Angeles, California • San Francisco, California • Evanston, Illinois + 13 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Evanston", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04219826" }, { "nct_id": "NCT07023614", "title": "A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Non-obstructive Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "Ninerafaxstat 200mg MR", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Imbria Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 165, "start_date": "2025-10-06", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2026-05-18", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 22, "location_summary": "La Jolla, California • Los Angeles, California • San Francisco, California + 18 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07023614" }, { "nct_id": "NCT05582395", "title": "A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Cardiomyopathy, Hypertrophic" ], "interventions": [ { "name": "Mavacamten", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 580, "start_date": "2022-12-14", "completion_date": "2025-10-20", "has_results": false, "last_update_posted_date": "2025-11-14", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 36 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05582395" }, { "nct_id": "NCT06081894", "title": "Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "Aficamten", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cytokinetics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 500, "start_date": "2023-08-30", "completion_date": "2026-09", "has_results": false, "last_update_posted_date": "2026-02-02", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 60, "location_summary": "Birmingham, Alabama • La Jolla, California • Los Angeles, California + 46 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06081894" }, { "nct_id": "NCT06775886", "title": "Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Non-obstructive Hypertrophic Cardiomyopathy", "Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "myPACE+ algorithm", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Montefiore Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1, "start_date": "2025-10-02", "completion_date": "2025-10-23", "has_results": false, "last_update_posted_date": "2026-02-11", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 1, "location_summary": "The Bronx, New York", "locations": [ { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06775886" }, { "nct_id": "NCT03723655", "title": "A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Hypertrophic Cardiomyopathy", "Obstructive Hypertrophic Cardiomyopathy", "Non-obstructive Hypertrophic Cardiomyopathy" ], "interventions": [ { "name": "mavacamten", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 314, "start_date": "2018-09-27", "completion_date": "2026-01-16", "has_results": false, "last_update_posted_date": "2026-02-20", "last_synced_at": "2026-07-23T14:34:52.691Z", "location_count": 31, "location_summary": "Scottsdale, Arizona • Los Angeles, California • San Francisco, California + 26 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT03723655" } ] }