{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Targeted+Temperature+Management&page=2",
    "query": {
      "condition": "Targeted Temperature Management",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Targeted+Temperature+Management&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T15:01:57.620Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01607151",
      "title": "Safety and Feasibility Study of Targeted Temperature Management After ICH",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Intracerebral Hemorrhage"
      ],
      "interventions": [
        {
          "name": "Normothermia",
          "type": "OTHER"
        },
        {
          "name": "Hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2013-01",
      "completion_date": "2016-06",
      "has_results": false,
      "last_update_posted_date": "2015-08-05",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01607151"
    },
    {
      "nct_id": "NCT03079284",
      "title": "Holding, Stress, and Bonding During Therapeutic Hypothermia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Holding during cooling",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Alexa Craig",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Hours",
        "maximum_age": "3 Days",
        "sex": "ALL",
        "summary": "24 Hours to 3 Days"
      },
      "enrollment_count": 10,
      "start_date": "2017-03-20",
      "completion_date": "2017-09-23",
      "has_results": true,
      "last_update_posted_date": "2025-09-04",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Portland, Maine",
      "locations": [
        {
          "city": "Portland",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03079284"
    },
    {
      "nct_id": "NCT03635450",
      "title": "Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Moderate to Severe Hypoxic-ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Infusion of hCT-MSC",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Joanne Kurtzberg, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Hours",
        "maximum_age": "48 Hours",
        "sex": "ALL",
        "summary": "0 Hours to 48 Hours"
      },
      "enrollment_count": 6,
      "start_date": "2018-12-27",
      "completion_date": "2020-12-28",
      "has_results": false,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635450"
    },
    {
      "nct_id": "NCT03409770",
      "title": "Optimising the Duration of Cooling in Mild Encephalopathy",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Encephalopathy",
        "Hypothermia Neonatal",
        "Magnetic Resonance Spectroscopy"
      ],
      "interventions": [
        {
          "name": "Therapeutic hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thayyil, Sudhin",
      "sponsor_class": "INDIV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 140,
      "start_date": "2019-10-10",
      "completion_date": "2024-08-30",
      "has_results": false,
      "last_update_posted_date": "2023-08-04",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Michigan Center, Michigan",
      "locations": [
        {
          "city": "Michigan Center",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03409770"
    },
    {
      "nct_id": "NCT01680744",
      "title": "The Effect of Therapeutic Hypothermia on Deceased Donor Renal Graft Outcomes - a Randomized Controlled Trial From the Region 5 Donor Management Goals Workgroup",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Deceased Organ Donor",
        "Mild Hypothermia",
        "Renal Function"
      ],
      "interventions": [
        {
          "name": "Hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 370,
      "start_date": "2012-05",
      "completion_date": "2014-11",
      "has_results": false,
      "last_update_posted_date": "2014-12-04",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01680744"
    },
    {
      "nct_id": "NCT03141255",
      "title": "Cardiogenic Shock Intravascular Cooling Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiogenic Shock"
      ],
      "interventions": [
        {
          "name": "IVTM™ System",
          "type": "DEVICE"
        },
        {
          "name": "Quattro® Catheter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 20,
      "start_date": "2017-11-06",
      "completion_date": "2021-11-01",
      "has_results": true,
      "last_update_posted_date": "2023-04-12",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03141255"
    },
    {
      "nct_id": "NCT01617291",
      "title": "Therapeutic Hypothermia After the Return of Spontaneous Circulation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiac Arrest"
      ],
      "interventions": [
        {
          "name": "Induced therapeutic hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2013-03",
      "completion_date": "2014-02",
      "has_results": false,
      "last_update_posted_date": "2014-02-14",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Fresno, California",
      "locations": [
        {
          "city": "Fresno",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01617291"
    },
    {
      "nct_id": "NCT07017998",
      "title": "External Therapy for Tinnitus Management",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tinnitus",
        "Tinnitus, Subjective"
      ],
      "interventions": [
        {
          "name": "Cold pack-delivered mild therapeutic hypothermia",
          "type": "DEVICE"
        },
        {
          "name": "Sham (No Treatment)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Restorear Devices LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 80,
      "start_date": "2025-07-16",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-17",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Bozeman, Montana",
      "locations": [
        {
          "city": "Bozeman",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07017998"
    },
    {
      "nct_id": "NCT04217551",
      "title": "Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiac Arrest, Out-Of-Hospital",
        "Hypothermia, Induced",
        "Hypoxia-Ischemia, Brain"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1158,
      "start_date": "2020-05-18",
      "completion_date": "2025-09-05",
      "has_results": false,
      "last_update_posted_date": "2025-06-25",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 76,
      "location_summary": "Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04217551"
    },
    {
      "nct_id": "NCT00703729",
      "title": "Compression and Cold Therapy on the Post-Operative Shoulder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postoperative Pain",
        "Shoulder Pain"
      ],
      "interventions": [
        {
          "name": "Cold Compression (CC)",
          "type": "DEVICE"
        },
        {
          "name": "Ice Wrap (IW)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 58,
      "start_date": "2008-06",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2015-09-10",
      "last_synced_at": "2026-06-07T15:01:57.620Z",
      "location_count": 1,
      "location_summary": "Boulder, Colorado",
      "locations": [
        {
          "city": "Boulder",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00703729"
    }
  ]
}