{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tissue+Plasminogen+Activator&page=2",
    "query": {
      "condition": "Tissue Plasminogen Activator",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tissue+Plasminogen+Activator&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T22:28:11.503Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01240356",
      "title": "CLOTBUST Hands-Free: A Phase I/II Pilot Safety Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "2-MHz transcranial Doppler ultrasound",
          "type": "DEVICE"
        },
        {
          "name": "2-MHz transcranial Doppler ultrasound insonation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2008-12",
      "completion_date": "2013-10",
      "has_results": true,
      "last_update_posted_date": "2016-05-23",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 2,
      "location_summary": "Birmingham, Alabama • Houston, Texas",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01240356"
    },
    {
      "nct_id": "NCT03897478",
      "title": "Biomarkers of Acute Stroke in Clinic",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ischemic Stroke",
        "Ischemia",
        "Atrial Fibrillation",
        "Transient Ischemic Attack",
        "Transient Cerebrovascular Events",
        "Thrombotic Stroke",
        "Stroke",
        "Stroke, Acute",
        "Stroke, Ischemic",
        "Stroke, Complication",
        "Stroke of Basilar Artery",
        "Atherosclerosis",
        "Atheroma",
        "Cardioembolic Stroke",
        "Cardiomyopathies",
        "Cardiovascular Stroke",
        "Thromboembolism"
      ],
      "interventions": [
        {
          "name": "ISCDX blood test",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Ischemia Care LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 500,
      "start_date": "2019-04-01",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-09-28",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03897478"
    },
    {
      "nct_id": "NCT07162363",
      "title": "Synergistic Minimally Invasive Surgery and Deferoxamine in ICH",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Intracerebral Hemorrhage",
        "ICH - Intracerebral Hemorrhage"
      ],
      "interventions": [
        {
          "name": "Minimally Invasive surgery (MIS)",
          "type": "PROCEDURE"
        },
        {
          "name": "Deferoxamine",
          "type": "DRUG"
        },
        {
          "name": "Standard Medical Care (SMD)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 240,
      "start_date": "2026-03-01",
      "completion_date": "2028-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-10-10",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07162363"
    },
    {
      "nct_id": "NCT02447094",
      "title": "Quality of Life After Stroke Using a Telemedicine-based Stroke Network",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Alteplase",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2015-02",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2016-02-09",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02447094"
    },
    {
      "nct_id": "NCT01878136",
      "title": "Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Subarachnoid Hemorrhage",
        "Cerebral Vasospasm",
        "Cerebral Aneurysm",
        "Hydrocephalus"
      ],
      "interventions": [
        {
          "name": "Tissue Plasminogen Activator",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2015-03",
      "completion_date": "2016-09",
      "has_results": false,
      "last_update_posted_date": "2015-11-11",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01878136"
    },
    {
      "nct_id": "NCT02315898",
      "title": "Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Plastic Bronchitis",
        "Protein-Losing Enteropathies",
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Treatment-inhaled tPA",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "24 Years",
        "sex": "ALL",
        "summary": "5 Years to 24 Years"
      },
      "enrollment_count": 40,
      "start_date": "2018-03-19",
      "completion_date": "2023-06-30",
      "has_results": true,
      "last_update_posted_date": "2025-08-19",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 6,
      "location_summary": "Palo Alto, California • Chicago, Illinois • Ann Arbor, Michigan + 3 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02315898"
    },
    {
      "nct_id": "NCT00284739",
      "title": "Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Abdominal Abscess",
        "Pelvic Abscess"
      ],
      "interventions": [
        {
          "name": "Alteplase",
          "type": "DRUG"
        },
        {
          "name": "saline",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Kaiser Permanente",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2006-02",
      "completion_date": "2007-10",
      "has_results": true,
      "last_update_posted_date": "2015-02-26",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Honolulu, Hawaii",
      "locations": [
        {
          "city": "Honolulu",
          "state": "Hawaii"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00284739"
    },
    {
      "nct_id": "NCT00245648",
      "title": "Female Sex is an Independent Predictor of Death and Bleeding Among Fibrinolytic Treated Patients With AMI",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Myocardial Infarction"
      ],
      "interventions": [
        {
          "name": "fibrinolytic therapy or combination reduced fibrinolytic therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2001-06",
      "completion_date": "2007-10",
      "has_results": false,
      "last_update_posted_date": "2012-10-04",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00245648"
    },
    {
      "nct_id": "NCT00029315",
      "title": "Intraventricular Rt-PA in Patients With Intraventricular Hemorrhage",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cerebral Hemorrhage"
      ],
      "interventions": [
        {
          "name": "Recombinant Tissue Plasminogen Activator (rt-PA)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 30,
      "start_date": "2001-09",
      "completion_date": "2004-09",
      "has_results": false,
      "last_update_posted_date": "2015-03-25",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00029315"
    },
    {
      "nct_id": "NCT00086723",
      "title": "In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Unspecified Adult Solid Tumor, Protocol Specific"
      ],
      "interventions": [
        {
          "name": "recombinant tissue plasminogen activator",
          "type": "BIOLOGICAL"
        },
        {
          "name": "captopril",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2003-07",
      "completion_date": "2006-01",
      "has_results": false,
      "last_update_posted_date": "2012-06-11",
      "last_synced_at": "2026-07-23T22:28:11.503Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00086723"
    }
  ]
}