{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Demineralization",
    "query": {
      "condition": "Tooth Demineralization"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 190,
    "total_pages": 19,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Demineralization&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T04:05:02.751Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00065988",
      "title": "The Children's Amalgam Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Dispersed phase amalgam restoration /composite restoration",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Carelon Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "10 Years",
        "sex": "ALL",
        "summary": "6 Years to 10 Years"
      },
      "enrollment_count": 534,
      "start_date": "1997-09",
      "completion_date": "2005-03",
      "has_results": false,
      "last_update_posted_date": "2010-04-28",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Watertown, Massachusetts",
      "locations": [
        {
          "city": "Watertown",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00065988"
    },
    {
      "nct_id": "NCT03196219",
      "title": "A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "C16G2",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Armata Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "12 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2017-07-07",
      "completion_date": "2018-01-10",
      "has_results": true,
      "last_update_posted_date": "2022-12-22",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Kalispell, Montana",
      "locations": [
        {
          "city": "Kalispell",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03196219"
    },
    {
      "nct_id": "NCT07261137",
      "title": "Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Caries, Dental",
        "Tooth Decay",
        "Dental Decay",
        "Tooth Sensitivity"
      ],
      "interventions": [
        {
          "name": "Vitrebond™ Pulp Protect Liner/Base",
          "type": "DEVICE"
        },
        {
          "name": "Vitrebond™ Plus (comparator)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Solventum US LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "7 Years to 89 Years"
      },
      "enrollment_count": 5,
      "start_date": "2026-02-17",
      "completion_date": "2026-04-15",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07261137"
    },
    {
      "nct_id": "NCT03294590",
      "title": "Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Caries, Dental",
        "Health Behavior"
      ],
      "interventions": [
        {
          "name": "OHT Parent targeted text messages",
          "type": "OTHER"
        },
        {
          "name": "CWT Parent targeted text messages",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boston University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "0 Months",
        "maximum_age": "7 Years",
        "sex": "ALL",
        "summary": "0 Months to 7 Years"
      },
      "enrollment_count": 754,
      "start_date": "2018-03-09",
      "completion_date": "2022-02-28",
      "has_results": true,
      "last_update_posted_date": "2023-10-24",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03294590"
    },
    {
      "nct_id": "NCT01567228",
      "title": "Delivering Geospatial Intelligence to Health Care Providers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Overweight"
      ],
      "interventions": [
        {
          "name": "CHICA GIS (enhanced electronic medical record)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "1 Year to 21 Years"
      },
      "enrollment_count": 1076,
      "start_date": "2012-09",
      "completion_date": "2014-09",
      "has_results": false,
      "last_update_posted_date": "2015-09-16",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01567228"
    },
    {
      "nct_id": "NCT05601154",
      "title": "Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Crest Cavity Protection toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse",
          "type": "DRUG"
        },
        {
          "name": "Colgate PreviDent 5000+ toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Colgate PreviDent 5000+ toothpaste followed by Act Mint Fluoride Rinse",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2023-03-23",
      "completion_date": "2025-02-28",
      "has_results": false,
      "last_update_posted_date": "2026-03-12",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05601154"
    },
    {
      "nct_id": "NCT00066950",
      "title": "Prevention Management Model for Early Childhood Caries (MAYA Project)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Chlorhexidine gluconate",
          "type": "DRUG"
        },
        {
          "name": "Fluoride Varnish",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "33 Years",
        "sex": "ALL",
        "summary": "18 Years to 33 Years"
      },
      "enrollment_count": 361,
      "start_date": "2003-03",
      "completion_date": "2005-08",
      "has_results": false,
      "last_update_posted_date": "2022-03-21",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 1,
      "location_summary": "San Ysidro, California",
      "locations": [
        {
          "city": "San Ysidro",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00066950"
    },
    {
      "nct_id": "NCT02340767",
      "title": "Decision Aids for the Management of Suspicious Occlusal Caries Lesions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Spectra Device",
          "type": "DEVICE"
        },
        {
          "name": "DIAGNOdent",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The National Dental Practice-Based Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "6 Years and older"
      },
      "enrollment_count": 3085,
      "start_date": "2014-12",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2019-04-03",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Rochester",
          "state": "New York"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02340767"
    },
    {
      "nct_id": "NCT04556175",
      "title": "Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Early Childhood Caries",
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Oral Health",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Healthy Lifestyle",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northern Arizona University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2021-03-29",
      "completion_date": "2022-03-01",
      "has_results": true,
      "last_update_posted_date": "2025-08-29",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 2,
      "location_summary": "Kykotsmovi, Arizona • Crow Agency, Montana",
      "locations": [
        {
          "city": "Kykotsmovi",
          "state": "Arizona"
        },
        {
          "city": "Crow Agency",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04556175"
    },
    {
      "nct_id": "NCT04666597",
      "title": "Pandemic-adapted Caries Care Multicentre Single-group Interventional Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dental Caries in Children"
      ],
      "interventions": [
        {
          "name": "Modified CariesCare International management",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Universidad El Bosque, Bogotá",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "8 Years",
        "sex": "ALL",
        "summary": "3 Years to 8 Years"
      },
      "enrollment_count": 409,
      "start_date": "2020-11-15",
      "completion_date": "2021-12-30",
      "has_results": false,
      "last_update_posted_date": "2023-12-04",
      "last_synced_at": "2026-06-11T04:05:02.751Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana • Boston, Massachusetts",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04666597"
    }
  ]
}