{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Discoloration",
    "query": {
      "condition": "Tooth Discoloration"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 11,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Discoloration&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T08:52:12.945Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04112706",
      "title": "Efficacy of CPP-ACP on Bleaching Related Sensitivity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Teeth Sensitivity",
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "CPP-ACP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of New England",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 40,
      "start_date": "2006-07-16",
      "completion_date": "2007-03-16",
      "has_results": false,
      "last_update_posted_date": "2019-10-02",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Portland, Maine",
      "locations": [
        {
          "city": "Portland",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04112706"
    },
    {
      "nct_id": "NCT04124068",
      "title": "Efficacy of Teeth Whitening Product Offerings in Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "Hydrogen peroxide teeth whitening gel",
          "type": "OTHER"
        },
        {
          "name": "GLO Brilliant Teeth Whitening Device",
          "type": "DEVICE"
        },
        {
          "name": "GLO Lit Teeth Whitening Device",
          "type": "DEVICE"
        },
        {
          "name": "GLO Science Professional Teeth Whitening Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Glo Science, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 75,
      "start_date": "2019-09-01",
      "completion_date": "2019-12-30",
      "has_results": false,
      "last_update_posted_date": "2020-02-05",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Mesa, Arizona",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04124068"
    },
    {
      "nct_id": "NCT04023097",
      "title": "Self-selection Study of the Toothwave Toothbrush",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gingivitis",
        "Plaque",
        "Calculus",
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "Toothwave toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Home Skinovations Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-07-02",
      "completion_date": "2019-07-09",
      "has_results": false,
      "last_update_posted_date": "2020-11-24",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04023097"
    },
    {
      "nct_id": "NCT02151058",
      "title": "A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Stain"
      ],
      "interventions": [
        {
          "name": "Colgate® Regular Cavity Protection",
          "type": "DRUG"
        },
        {
          "name": "Experimental Mouth Rinse",
          "type": "DRUG"
        },
        {
          "name": "Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Johnson & Johnson Consumer and Personal Products Worldwide",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 227,
      "start_date": "2014-06",
      "completion_date": "2014-07",
      "has_results": true,
      "last_update_posted_date": "2015-06-01",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02151058"
    },
    {
      "nct_id": "NCT06802614",
      "title": "Efficacy and Safety Assessment of Experimental Bleaching Agents",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration",
        "Dentin Sensitivity",
        "Patient Satisfaction"
      ],
      "interventions": [
        {
          "name": "BLEACHING GEL A",
          "type": "DEVICE"
        },
        {
          "name": "5% NF_TiO2",
          "type": "DEVICE"
        },
        {
          "name": "BLEACHING GEL B",
          "type": "DEVICE"
        },
        {
          "name": "VISIBLE LIGHT IRRADIATION",
          "type": "RADIATION"
        },
        {
          "name": "Whiteness HP 35%",
          "type": "DEVICE"
        },
        {
          "name": "Whiteness HP Automixx 6%",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "RADIATION"
      ],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 240,
      "start_date": "2025-03-01",
      "completion_date": "2025-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-01-31",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06802614"
    },
    {
      "nct_id": "NCT05459558",
      "title": "Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "Experimental Dentifrice 1",
          "type": "DRUG"
        },
        {
          "name": "Experimental Dentifrice 2",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 280,
      "start_date": "2022-09-15",
      "completion_date": "2022-12-04",
      "has_results": true,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05459558"
    },
    {
      "nct_id": "NCT03885609",
      "title": "Safety and Efficacy of the ToothWave Power Toothbrush for Extrinsic Stain Reduction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "ToothWave",
          "type": "DEVICE"
        },
        {
          "name": "powered toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Home Skinovations Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 84,
      "start_date": "2019-02-28",
      "completion_date": "2019-04-12",
      "has_results": false,
      "last_update_posted_date": "2019-09-10",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03885609"
    },
    {
      "nct_id": "NCT07667088",
      "title": "Oil Pulling Whitening Mouthwash",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Adult Participants",
        "Tooth Stain"
      ],
      "interventions": [
        {
          "name": "GuruNanda natural Oil Pulling oral rinse",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Therabreath Whitening Mouthwash - Dazzling Mint",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "GuruNanda water-based non-whitening mouthwash",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 120,
      "start_date": "2026-05-01",
      "completion_date": "2026-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-24",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07667088"
    },
    {
      "nct_id": "NCT04092062",
      "title": "Safety and Efficacy of the ToothWave Powered Toothbrush for Extrinsic Stain Reduction (Texas)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration"
      ],
      "interventions": [
        {
          "name": "ToothWave",
          "type": "DEVICE"
        },
        {
          "name": "powered toothbrush",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Home Skinovations Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 91,
      "start_date": "2019-08-07",
      "completion_date": "2020-01-28",
      "has_results": false,
      "last_update_posted_date": "2020-12-11",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04092062"
    },
    {
      "nct_id": "NCT02906982",
      "title": "Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Discoloration",
        "Periodontal Diseases"
      ],
      "interventions": [
        {
          "name": "Gum health formulation in intra-oral device",
          "type": "OTHER"
        },
        {
          "name": "Gum health formulation on toothbrush",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Glo Science, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 30,
      "start_date": "2015-10",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-09-20",
      "last_synced_at": "2026-07-22T08:52:12.945Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02906982"
    }
  ]
}