{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Diseases&page=25",
    "query": {
      "condition": "Tooth Diseases",
      "page": 25
    },
    "page_size": 10
  },
  "pagination": {
    "page": 25,
    "page_size": 10,
    "total_count": 692,
    "total_pages": 70,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Diseases&page=26&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Tooth+Diseases&page=24&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-11-15T10:21:30.916Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02360995",
      "title": "The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dental Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Triclosan/fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "stannous fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "fluoride toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Fluoride Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "cetylpyridinium chloride Mouthwash",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 129,
      "start_date": "2014-06",
      "completion_date": "2014-08",
      "has_results": true,
      "last_update_posted_date": "2016-03-30",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02360995"
    },
    {
      "nct_id": "NCT00223405",
      "title": "Analysis of Enamel Wear Against Ceramic Restorations",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tooth Wear"
      ],
      "interventions": [
        {
          "name": "crown placement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 36,
      "start_date": "2003-04",
      "completion_date": "2009-01",
      "has_results": false,
      "last_update_posted_date": "2016-11-22",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00223405"
    },
    {
      "nct_id": "NCT01021007",
      "title": "Clinical Research Study Efficacy of a Prototype Oral Rinse",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Iodine",
          "type": "DRUG"
        },
        {
          "name": "water",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 67,
      "start_date": "2007-10",
      "completion_date": "2007-11",
      "has_results": true,
      "last_update_posted_date": "2009-12-01",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Northfield, New Jersey",
      "locations": [
        {
          "city": "Northfield",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01021007"
    },
    {
      "nct_id": "NCT03722264",
      "title": "An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cavities of Teeth"
      ],
      "interventions": [
        {
          "name": "OpalSeal",
          "type": "DEVICE"
        },
        {
          "name": "TransbondXT",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "10 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2017-11-16",
      "completion_date": "2019-04-12",
      "has_results": true,
      "last_update_posted_date": "2020-03-04",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03722264"
    },
    {
      "nct_id": "NCT06330207",
      "title": "An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Emergency Department Visit",
        "Odontalgia"
      ],
      "interventions": [
        {
          "name": "Clinical decision support tool",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2026-01-15",
      "completion_date": "2027-08-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-14",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06330207"
    },
    {
      "nct_id": "NCT03678012",
      "title": "Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Ferumoxytol/Hydrogen peroxide",
          "type": "DRUG"
        },
        {
          "name": "Hydrogen Peroxide",
          "type": "DRUG"
        },
        {
          "name": "Water",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 16,
      "start_date": "2018-06-07",
      "completion_date": "2018-08-16",
      "has_results": false,
      "last_update_posted_date": "2018-09-19",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 2,
      "location_summary": "Indianapolis, Indiana • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03678012"
    },
    {
      "nct_id": "NCT01594411",
      "title": "PCP Use of a Gene Expression Test (Corus CAD or ASGES) in Coronary Artery Disease Diagnosis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chest Pain",
        "Cardiovascular Diseases",
        "Angina Pectoris",
        "Coronary Artery Disease",
        "CAD",
        "CVD",
        "CHD",
        "Coronary Heart Disease"
      ],
      "interventions": [
        {
          "name": "Corus CAD",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "CardioDx",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 251,
      "start_date": "2012-04",
      "completion_date": "2013-02",
      "has_results": true,
      "last_update_posted_date": "2019-01-31",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 4,
      "location_summary": "Suwanee, Georgia • Baton Rouge, Louisiana • Charlotte, North Carolina + 1 more",
      "locations": [
        {
          "city": "Suwanee",
          "state": "Georgia"
        },
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        },
        {
          "city": "Bonham",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01594411"
    },
    {
      "nct_id": "NCT06984744",
      "title": "4-day Plaque Accumulation Model Evaluating Compound Containing Gum",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Plaque Accumulation"
      ],
      "interventions": [
        {
          "name": "MIIP-E2 containing gum",
          "type": "DEVICE"
        },
        {
          "name": "placebo gum without MIIP-E2",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Lactea Therapeutics, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2025-06-23",
      "completion_date": "2026-02-27",
      "has_results": false,
      "last_update_posted_date": "2025-08-27",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06984744"
    },
    {
      "nct_id": "NCT07029438",
      "title": "Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dental Plaque",
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Mouthwash",
          "type": "DRUG"
        },
        {
          "name": "Floss",
          "type": "DEVICE"
        },
        {
          "name": "Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "Toothpaste",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 228,
      "start_date": "2025-07-07",
      "completion_date": "2025-10-16",
      "has_results": false,
      "last_update_posted_date": "2025-10-30",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07029438"
    },
    {
      "nct_id": "NCT02940353",
      "title": "The TREFOIL Concept 5 Year Clinical Investigation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Edentulous or Failing Dentition Mandible"
      ],
      "interventions": [
        {
          "name": "TREFOIL concept",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Nobel Biocare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 110,
      "start_date": "2016-04",
      "completion_date": "2022-06",
      "has_results": false,
      "last_update_posted_date": "2023-03-22",
      "last_synced_at": "2026-11-15T10:21:30.916Z",
      "location_count": 1,
      "location_summary": "Spokane, Washington",
      "locations": [
        {
          "city": "Spokane",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02940353"
    }
  ]
}