{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Total+Ankle+Replacement",
    "query": {
      "condition": "Total Ankle Replacement"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 29,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Total+Ankle+Replacement&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:09:59.558Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07212114",
      "title": "Efficacy of EXPAREL vs. Bupivacaine",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Total Ankle Arthroplasty",
        "Postsurgical Analgesia"
      ],
      "interventions": [
        {
          "name": "EXPAREL",
          "type": "DRUG"
        },
        {
          "name": "0.25% bupivacaine (HCl): 50 ml",
          "type": "DRUG"
        },
        {
          "name": "0.25% bupivacaine (HCl): 30 ml",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 104,
      "start_date": "2025-11-17",
      "completion_date": "2029-08",
      "has_results": false,
      "last_update_posted_date": "2026-02-23",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07212114"
    },
    {
      "nct_id": "NCT05231304",
      "title": "Retrospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Talus",
        "Ankle Arthropathy"
      ],
      "interventions": [
        {
          "name": "Total Talus Replacement (TTR)",
          "type": "PROCEDURE"
        },
        {
          "name": "Total Ankle Total Talus Replacement (TATTR)",
          "type": "PROCEDURE"
        },
        {
          "name": "Total Ankle Total Talus Replacement + Subtalar Fusion (TATTR + STJ)",
          "type": "PROCEDURE"
        },
        {
          "name": "Total Talus Replacement + Subtalar Fusion (TTR + STJ)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Restor3D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2022-04-05",
      "completion_date": "2024-02-19",
      "has_results": false,
      "last_update_posted_date": "2024-02-21",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 2,
      "location_summary": "Paducah, Kentucky • Bellevue, Ohio",
      "locations": [
        {
          "city": "Paducah",
          "state": "Kentucky"
        },
        {
          "city": "Bellevue",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05231304"
    },
    {
      "nct_id": "NCT03142958",
      "title": "Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)",
      "overall_status": "SUSPENDED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rheumatoid Arthritis",
        "Degenerative Arthritis",
        "Post Traumatic Arthritis"
      ],
      "interventions": [
        {
          "name": "Integra Cadence Total Ankle System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 132,
      "start_date": "2017-08-24",
      "completion_date": "2025-04-30",
      "has_results": false,
      "last_update_posted_date": "2024-11-12",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 9,
      "location_summary": "San Francisco, California • Sarasota, Florida • Buffalo, New York + 5 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Sarasota",
          "state": "Florida"
        },
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Westerville",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03142958"
    },
    {
      "nct_id": "NCT00586781",
      "title": "Study of the Scandinavian Total Ankle Replacement (STAR) for the Treatment of Bilateral Degenerative Ankle Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis",
        "Post-Traumatic Arthritis",
        "Rheumatoid Arthritis"
      ],
      "interventions": [
        {
          "name": "Scandinavian Total Ankle Replacement (STAR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Link America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2001-09",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2008-01-04",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 5,
      "location_summary": "Jacksonville, Florida • Iowa City, Iowa • Kansas City, Kansas + 2 more",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00586781"
    },
    {
      "nct_id": "NCT03390426",
      "title": "Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Tourniquet Hypertension",
        "Intraoperative Hypertension",
        "Total Ankle Arthroplasty",
        "Ankle Fusion"
      ],
      "interventions": [
        {
          "name": "Mepivacaine",
          "type": "DRUG"
        },
        {
          "name": "Perifemoral Injection of Local Anesthetic",
          "type": "PROCEDURE"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 31,
      "start_date": "2018-05-03",
      "completion_date": "2018-10-28",
      "has_results": true,
      "last_update_posted_date": "2021-05-05",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03390426"
    },
    {
      "nct_id": "NCT04770870",
      "title": "Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis Ankle",
        "Post-Traumatic Osteoarthritis of Ankle",
        "Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)"
      ],
      "interventions": [
        {
          "name": "Hintermann Series H3 Total Ankle Replacement System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DT MedTech, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 232,
      "start_date": "2022-02-01",
      "completion_date": "2029-04",
      "has_results": false,
      "last_update_posted_date": "2024-06-25",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 10,
      "location_summary": "Mission Hills, California • Sarasota, Florida • West Palm Beach, Florida + 7 more",
      "locations": [
        {
          "city": "Mission Hills",
          "state": "California"
        },
        {
          "city": "Sarasota",
          "state": "Florida"
        },
        {
          "city": "West Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Evansville",
          "state": "Indiana"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04770870"
    },
    {
      "nct_id": "NCT07118501",
      "title": "A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post Traumatic Arthritis",
        "Osteoarthritis",
        "Total Ankle Replacement",
        "Total Ankle Prosthesis"
      ],
      "interventions": [
        {
          "name": "Total Ankle Replacement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stryker Trauma and Extremities",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2026-02-06",
      "completion_date": "2038-09-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-24",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 4,
      "location_summary": "Morton Grove, Illinois • Louisville, Kentucky • Eugene, Oregon + 1 more",
      "locations": [
        {
          "city": "Morton Grove",
          "state": "Illinois"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Eugene",
          "state": "Oregon"
        },
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07118501"
    },
    {
      "nct_id": "NCT04518462",
      "title": "Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Lower Extremity Surgery",
        "Bunion",
        "Metatarsophalangeal Fushion",
        "Midfoot Fusion",
        "Hindfoot Fushion",
        "Total Ankle Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Exparel",
          "type": "DRUG"
        },
        {
          "name": "Bupivacaine Hydrochloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 121,
      "start_date": "2020-10-20",
      "completion_date": "2021-04-05",
      "has_results": true,
      "last_update_posted_date": "2022-07-18",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 5,
      "location_summary": "Phoenix, Arizona • Pasadena, California • Boston, Massachusetts + 2 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "Bellaire",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04518462"
    },
    {
      "nct_id": "NCT04454203",
      "title": "Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Tourniquet Hypertension",
        "Intraoperative Hypertension",
        "Total Ankle Arthroplasty",
        "Ankle Fusion"
      ],
      "interventions": [
        {
          "name": "Mepivacaine",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        },
        {
          "name": "Perifemoral Injection of Local Anesthetic",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 40,
      "start_date": "2021-02-05",
      "completion_date": "2027-02-03",
      "has_results": false,
      "last_update_posted_date": "2026-03-23",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04454203"
    },
    {
      "nct_id": "NCT04709861",
      "title": "TAR 2 Weeks vs 6 Weeks Post-Operative Weight-Bearing",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Ankle Osteoarthritis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Oklahoma",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 33,
      "start_date": "2021-04-07",
      "completion_date": "2024-03-16",
      "has_results": false,
      "last_update_posted_date": "2024-04-24",
      "last_synced_at": "2026-05-22T08:09:59.558Z",
      "location_count": 1,
      "location_summary": "Oklahoma City, Oklahoma",
      "locations": [
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04709861"
    }
  ]
}