{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Total+Knee+Arthroplasty&page=2",
    "query": {
      "condition": "Total Knee Arthroplasty",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Total+Knee+Arthroplasty&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:08:53.066Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01367938",
      "title": "Clinical Outcomes With Omni Apex Ultracongruent Knee System",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "OMNI Apex Ultracongruent Knee Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Spokane Joint Replacement Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 69,
      "start_date": "2009-11",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2018-12-05",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Spokane, Washington",
      "locations": [
        {
          "city": "Spokane",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01367938"
    },
    {
      "nct_id": "NCT02081911",
      "title": "Total Knee Arthroplasty Utilizing Adductor Canal Block: Effect on Quadriceps Sparing",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis (Knee)"
      ],
      "interventions": [
        {
          "name": "High Volume Adductor Canal Block",
          "type": "PROCEDURE"
        },
        {
          "name": "Low Volume Adductor Canal Block",
          "type": "PROCEDURE"
        },
        {
          "name": "Femoral Nerve Block",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 33,
      "start_date": "2014-02",
      "completion_date": "2015-12",
      "has_results": false,
      "last_update_posted_date": "2016-02-02",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02081911"
    },
    {
      "nct_id": "NCT00371683",
      "title": "Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Deep Vein Thrombosis",
        "Pulmonary Embolism"
      ],
      "interventions": [
        {
          "name": "Enoxaparin + Placebo",
          "type": "DRUG"
        },
        {
          "name": "Apixaban + Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bristol-Myers Squibb",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3608,
      "start_date": "2006-11",
      "completion_date": "2008-05",
      "has_results": true,
      "last_update_posted_date": "2015-12-30",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 25,
      "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Little Rock, Arkansas + 17 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Tuscaloosa",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00371683"
    },
    {
      "nct_id": "NCT05593341",
      "title": "Opioid Education in Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthropathy of Knee",
        "Post Operative Pain",
        "Opioid Use",
        "Opioid Abuse",
        "Opioid Misuse"
      ],
      "interventions": [
        {
          "name": "Opioid education in person",
          "type": "OTHER"
        },
        {
          "name": "Opioid education via video",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 42,
      "start_date": "2022-09-27",
      "completion_date": "2023-09-11",
      "has_results": false,
      "last_update_posted_date": "2024-12-27",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05593341"
    },
    {
      "nct_id": "NCT02034032",
      "title": "Regenexx™ SD Versus Exercise Therapy for Treatment of Knee Osteoarthritis With Historical Comparison to TKA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Regenexx SD",
          "type": "PROCEDURE"
        },
        {
          "name": "Exercise Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "Regenexx, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 48,
      "start_date": "2014-01",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2019-01-04",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Des Plaines, Illinois",
      "locations": [
        {
          "city": "Des Plaines",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02034032"
    },
    {
      "nct_id": "NCT04618770",
      "title": "Triathlon PSR Outcomes Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthroplasty",
        "Knee"
      ],
      "interventions": [
        {
          "name": "Triathlon PSR Tibial Insert",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stryker Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 37,
      "start_date": "2021-02-08",
      "completion_date": "2023-01-27",
      "has_results": true,
      "last_update_posted_date": "2023-12-11",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04618770"
    },
    {
      "nct_id": "NCT00698854",
      "title": "A Clinical Investigation of the Vanguard™ Complete Knee System",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis",
        "Traumatic Arthritis",
        "Rheumatoid Arthritis",
        "Lower Limb Deformity",
        "Complications, Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Vanguard™ Complete Knee System",
          "type": "DEVICE"
        },
        {
          "name": "Vanguard™ Patient-Specific Femur",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 552,
      "start_date": "2004-03",
      "completion_date": "2024-03",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 8,
      "location_summary": "Cedar Rapids, Iowa • Rockville, Maryland • Cape Girardeau, Missouri + 5 more",
      "locations": [
        {
          "city": "Cedar Rapids",
          "state": "Iowa"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Cape Girardeau",
          "state": "Missouri"
        },
        {
          "city": "Rochester",
          "state": "New York"
        },
        {
          "city": "Grapevine",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00698854"
    },
    {
      "nct_id": "NCT03534102",
      "title": "Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Opioid Use",
        "Opioid Dependence",
        "Knee Pain Chronic",
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Improved Opioid-Tapering Instructions",
          "type": "DRUG"
        },
        {
          "name": "Clinical Patient Educator",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2022-06-06",
      "completion_date": "2024-09-01",
      "has_results": false,
      "last_update_posted_date": "2023-02-27",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03534102"
    },
    {
      "nct_id": "NCT02693457",
      "title": "Outcomes Following Suction Drain and Non-suction Drain Assisted Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Bilateral Total Knee Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Drain",
          "type": "PROCEDURE"
        },
        {
          "name": "No Drain",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Colorado Joint Replacement",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "Up to 70 Years"
      },
      "enrollment_count": 29,
      "start_date": "2016-02",
      "completion_date": "2017-12-29",
      "has_results": false,
      "last_update_posted_date": "2018-07-17",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02693457"
    },
    {
      "nct_id": "NCT02255500",
      "title": "EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pain"
      ],
      "interventions": [
        {
          "name": "Bupivacaine FNB",
          "type": "DRUG"
        },
        {
          "name": "EXPAREL Infiltration",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2014-09",
      "completion_date": "2015-03",
      "has_results": true,
      "last_update_posted_date": "2021-03-08",
      "last_synced_at": "2026-05-22T05:08:53.066Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02255500"
    }
  ]
}