{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Traumatic+Brain+Injury+With+Open+Intracranial+Wound",
    "query": {
      "condition": "Traumatic Brain Injury With Open Intracranial Wound"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T07:49:29.698Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03496545",
      "title": "Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Subarachnoid Hemorrhage",
        "Subdural Hematoma",
        "Traumatic Brain Injury",
        "Ischemic Stroke",
        "Fever",
        "Intracerebral Hemorrhage"
      ],
      "interventions": [
        {
          "name": "Bromocriptine 5 MG",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen 650 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 47,
      "start_date": "2018-11-30",
      "completion_date": "2019-11-02",
      "has_results": true,
      "last_update_posted_date": "2021-06-24",
      "last_synced_at": "2026-05-22T07:49:29.698Z",
      "location_count": 2,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03496545"
    },
    {
      "nct_id": "NCT05636020",
      "title": "Intervention to Change Affect Recognition and Empathy",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Concussion, Intermediate",
        "Concussion, Severe",
        "Concussion With LOC 31 to 59 Minutes",
        "Concussion With Brief Loss of Consciousness",
        "Traumatic Brain Injury With Brief Loss of Consciousness",
        "Traumatic Brain Injury With Loss of Consciousness",
        "Traumatic Brain Injury With Prolonged Loss of Consciousness",
        "Traumatic Brain Injury (TBI); Concussion, Initial Encounter",
        "Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter",
        "Traumatic Brain Injury With No Loss of Consciousness",
        "Traumatic Brain Injury With Open Intracranial Wound",
        "Traumatic Brain Injury With Moderate Loss of Consciousness"
      ],
      "interventions": [
        {
          "name": "ICARE Treatment",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 85,
      "start_date": "2023-03-15",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2025-11-03",
      "last_synced_at": "2026-05-22T07:49:29.698Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05636020"
    },
    {
      "nct_id": "NCT06510582",
      "title": "Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Chronic Subdural Hematoma"
      ],
      "interventions": [
        {
          "name": "Bevacizumab 2 mg/kg",
          "type": "DRUG"
        },
        {
          "name": "Bevacizumab 4 mg/kg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The Cooper Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 140,
      "start_date": "2024-06-17",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2025-07-01",
      "last_synced_at": "2026-05-22T07:49:29.698Z",
      "location_count": 1,
      "location_summary": "Camden, New Jersey",
      "locations": [
        {
          "city": "Camden",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06510582"
    },
    {
      "nct_id": "NCT00174980",
      "title": "Study of Oxycyte in Severe Closed Head Injury",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Oxycyte",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tenax Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 9,
      "start_date": "2005-09",
      "completion_date": "2008-04",
      "has_results": true,
      "last_update_posted_date": "2026-02-24",
      "last_synced_at": "2026-05-22T07:49:29.698Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00174980"
    }
  ]
}