{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Treatment+Resistant+Major+Depressive+Disorder", "query": { "condition": "Treatment Resistant Major Depressive Disorder" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 163, "total_pages": 17, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Treatment+Resistant+Major+Depressive+Disorder&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-11T02:54:51.887Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05454410", "title": "Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Treatment-Resistant Depression" ], "interventions": [ { "name": "MIJ821 Subcutaneous Injection 1 mg", "type": "DRUG" }, { "name": "MIJ821 Subcutaneous Injection 4 mg", "type": "DRUG" }, { "name": "MIJ821 Subcutaneous Injection 10 mg", "type": "DRUG" }, { "name": "Placebo Subcutaneous Injection", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2023-03-13", "completion_date": "2023-11-28", "has_results": true, "last_update_posted_date": "2025-04-13", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 3, "location_summary": "Birmingham, Alabama • Oakland Park, Florida • Tampa, Florida", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Oakland Park", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05454410" }, { "nct_id": "NCT05393622", "title": "Brain Stimulation for Severe Depression", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Depression Severe" ], "interventions": [ { "name": "INTRACALVARIAL PREFRONTAL CORTICAL STIMULATION (IpCS) IN SEVERE TREATMENT-RESISTANT DEPRESSION", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Inner Cosmos Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "21 Years to 80 Years" }, "enrollment_count": 20, "start_date": "2022-07-28", "completion_date": "2027-12", "has_results": false, "last_update_posted_date": "2026-04-15", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 2, "location_summary": "Boston, Massachusetts • St Louis, Missouri", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT05393622" }, { "nct_id": "NCT02994433", "title": "NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Depressive Disorder, Major", "Depressive Disorder, Treatment-Resistant" ], "interventions": [ { "name": "Nitrous Oxide", "type": "DRUG" }, { "name": "Placebo gas", "type": "DRUG" }, { "name": "MRI", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Washington University School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2017-01-27", "completion_date": "2027-04-30", "has_results": false, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT02994433" }, { "nct_id": "NCT00021528", "title": "Sequenced Treatment Alternatives to Relieve Depression (STAR*D)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "citalopram", "type": "DRUG" }, { "name": "BuproprionSR", "type": "DRUG" }, { "name": "buspirone", "type": "DRUG" }, { "name": "Lithium", "type": "DRUG" }, { "name": "mirtazapine", "type": "DRUG" }, { "name": "nortriptyline", "type": "DRUG" }, { "name": "sertraline", "type": "DRUG" }, { "name": "tranylcypromine", "type": "DRUG" }, { "name": "VenlafaxineXR", "type": "DRUG" }, { "name": "Cognitive Therapy", "type": "BEHAVIORAL" }, { "name": "T3 (Triiodothyronine)", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 4000, "start_date": "2001-07", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2009-09-25", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Chula Vista", "state": "California" }, { "city": "Harbor City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00021528" }, { "nct_id": "NCT04106466", "title": "DBS for TRD With the Medtronic Summit RC+S", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder", "Treatment Resistant Depression" ], "interventions": [ { "name": "Medtronic Summit RC+S DBS system", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Helen Mayberg, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "25 Years to 70 Years" }, "enrollment_count": 10, "start_date": "2020-01-21", "completion_date": "2030-12-31", "has_results": false, "last_update_posted_date": "2026-02-17", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT04106466" }, { "nct_id": "NCT00715559", "title": "Cysteamine Therapy for Major Depressive Disorder", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Major Depressive Disorder" ], "interventions": [ { "name": "cysteamine bitartrate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 3, "start_date": "2008-07", "completion_date": "2009-05", "has_results": true, "last_update_posted_date": "2017-04-07", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00715559" }, { "nct_id": "NCT00320372", "title": "Treatment-Resistant Depression Registry", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Major Depressive Disorder" ], "interventions": [], "intervention_types": [], "sponsor": "Cyberonics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 795, "start_date": "2006-01", "completion_date": "2015-05", "has_results": true, "last_update_posted_date": "2015-12-23", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 55, "location_summary": "Tucson, Arizona • Beverly Hills, California • Garden Grove, California + 46 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00320372" }, { "nct_id": "NCT00463580", "title": "A Study of Infliximab for Treatment Resistant Major Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "Infliximab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "25 Years to 60 Years" }, "enrollment_count": 60, "start_date": "2008-12", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2025-07-08", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00463580" }, { "nct_id": "NCT04971291", "title": "An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Major Depressive Disorder", "Treatment Resistant Depression" ], "interventions": [ { "name": "AXS-05", "type": "DRUG" }, { "name": "Bupropion SR", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Axsome Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 312, "start_date": "2021-04-14", "completion_date": "2021-07", "has_results": false, "last_update_posted_date": "2021-07-26", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT04971291" }, { "nct_id": "NCT06511908", "title": "Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Suicide", "Depressive Disorder, Treatment-Resistant", "Ketamine", "Molecular Mechanisms of Pharmacological Action", "Neurotransmitter Agents", "Excitatory Amino Acid Agents", "Physiological Effects of Drugs", "Depressive Disorder, Major", "Depressive Disorder", "Depression", "Mental Disorders", "Mood Disorders", "Behavioral Symptoms" ], "interventions": [ { "name": "(2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 50, "start_date": "2024-11-06", "completion_date": "2027-07-01", "has_results": false, "last_update_posted_date": "2026-04-16", "last_synced_at": "2026-06-11T02:54:51.887Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT06511908" } ] }