{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Treatment-resistant+Bipolar+Depression",
    "query": {
      "condition": "Treatment-resistant Bipolar Depression"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 35,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Treatment-resistant+Bipolar+Depression&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:45:42.861Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05172271",
      "title": "Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Bipolar Disorder",
        "Unipolar Major Depression"
      ],
      "interventions": [
        {
          "name": "MagPro TMS Stimulator and coil",
          "type": "DEVICE"
        },
        {
          "name": "Thymatron(R) System IV",
          "type": "DEVICE"
        },
        {
          "name": "Magnetic Resonance Imaging Scanner",
          "type": "DEVICE"
        },
        {
          "name": "ECT device without stimulation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "National Institute of Mental Health (NIMH)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "25 Years to 64 Years"
      },
      "enrollment_count": 8,
      "start_date": "2022-11-08",
      "completion_date": "2027-10-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-17",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05172271"
    },
    {
      "nct_id": "NCT03953417",
      "title": "Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Treatment Resistant Depression"
      ],
      "interventions": [
        {
          "name": "Accelerated intermittent theta-burst treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 7,
      "start_date": "2019-07-01",
      "completion_date": "2023-12-30",
      "has_results": true,
      "last_update_posted_date": "2026-02-04",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03953417"
    },
    {
      "nct_id": "NCT01504659",
      "title": "Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "Ketamine hydrochloride injection",
          "type": "DRUG"
        },
        {
          "name": "Flat tonic water (e.g., Canada Dry Tonic Water)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Juvenile Bipolar Research Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "6 Years to 12 Years"
      },
      "enrollment_count": 5,
      "start_date": "2012-07",
      "completion_date": "2016-11",
      "has_results": false,
      "last_update_posted_date": "2017-03-16",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 4,
      "location_summary": "Not Predetermined, Connecticut • Maplewood, New Jersey • Not Predetermined, New Jersey + 1 more",
      "locations": [
        {
          "city": "Not Predetermined",
          "state": "Connecticut"
        },
        {
          "city": "Maplewood",
          "state": "New Jersey"
        },
        {
          "city": "Not Predetermined",
          "state": "New Jersey"
        },
        {
          "city": "Not Predetermined",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01504659"
    },
    {
      "nct_id": "NCT06748950",
      "title": "Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Schizophrenia",
        "Schizophrenia and Related Disorders",
        "Bipolar Disorder",
        "Bipolar and Related Disorders",
        "Major Depressive Disorder",
        "Major Depression Severe",
        "Ketogenic Dieting",
        "Ketosis",
        "Metabolic Disease",
        "Metabolic Syndrome"
      ],
      "interventions": [
        {
          "name": "LCHF Ketogenic Diet",
          "type": "OTHER"
        },
        {
          "name": "Diet-as-Usual (DAU)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 120,
      "start_date": "2025-07",
      "completion_date": "2028-07",
      "has_results": false,
      "last_update_posted_date": "2025-05-16",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06748950"
    },
    {
      "nct_id": "NCT03522545",
      "title": "Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Treatment-resistant Bipolar Depression"
      ],
      "interventions": [
        {
          "name": "Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs)",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 30,
      "start_date": "2022-04-20",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2025-06-22",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03522545"
    },
    {
      "nct_id": "NCT05228457",
      "title": "Intensive TMS for Bipolar Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bipolar Depression",
        "Treatment Resistant Depression"
      ],
      "interventions": [
        {
          "name": "Intensive intermittent theta-burst stimulation (iTBS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 34,
      "start_date": "2022-03-01",
      "completion_date": "2024-02-19",
      "has_results": true,
      "last_update_posted_date": "2025-03-12",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05228457"
    },
    {
      "nct_id": "NCT03290963",
      "title": "Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Treatment Resistant Depression"
      ],
      "interventions": [
        {
          "name": "Lithium",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "William V. Bobo, M.D.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 0,
      "start_date": "2017-11-30",
      "completion_date": "2018-12",
      "has_results": false,
      "last_update_posted_date": "2018-08-16",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03290963"
    },
    {
      "nct_id": "NCT07127913",
      "title": "Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bipolar II Disorder",
        "Bipolar II Disorder, Most Recent Episode Major Depressive"
      ],
      "interventions": [
        {
          "name": "Device: Stimulation-ON",
          "type": "DEVICE"
        },
        {
          "name": "Device: Stimulation-OFF",
          "type": "DEVICE"
        },
        {
          "name": "Device: Stimulation -ON Active Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Andrew Krystal",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "22 Years to 70 Years"
      },
      "enrollment_count": 10,
      "start_date": "2025-07-16",
      "completion_date": "2035-06-28",
      "has_results": false,
      "last_update_posted_date": "2025-08-17",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07127913"
    },
    {
      "nct_id": "NCT00947791",
      "title": "Treatment Study of Bipolar Depression",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "ketamine",
          "type": "DRUG"
        },
        {
          "name": "midazolam",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 1,
      "start_date": "2009-07",
      "completion_date": "2009-10",
      "has_results": true,
      "last_update_posted_date": "2017-05-17",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00947791"
    },
    {
      "nct_id": "NCT01717040",
      "title": "Pioglitazone for the Treatment of Bipolar Depression",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Bipolar Disorder",
        "Insulin Resistance"
      ],
      "interventions": [
        {
          "name": "Pioglitazone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University Hospitals Cleveland Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 37,
      "start_date": "2012-09",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2017-01-27",
      "last_synced_at": "2026-05-22T09:45:42.861Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01717040"
    }
  ]
}