{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Twin+to+Twin+Transfusion",
    "query": {
      "condition": "Twin to Twin Transfusion"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 19,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Twin+to+Twin+Transfusion&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T06:43:38.359Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00345852",
      "title": "Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Twin to Twin Transfusion Syndrome"
      ],
      "interventions": [
        {
          "name": "Fetoscopic Selective Laser Photocoagulation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 150,
      "start_date": "2002-03",
      "completion_date": "2007-05",
      "has_results": false,
      "last_update_posted_date": "2007-06-29",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 12,
      "location_summary": "San Francisco, California • Evanston, Illinois • New York, New York + 7 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Evanston",
          "state": "Illinois"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00345852"
    },
    {
      "nct_id": "NCT06022510",
      "title": "Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Twin Monochorionic Diamniotic Placenta"
      ],
      "interventions": [
        {
          "name": "Fetoscopy Sets for Anterior and Posterior Placentas",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Michael A Belfort",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2025-04",
      "completion_date": "2025-04-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06022510"
    },
    {
      "nct_id": "NCT01220011",
      "title": "Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Blood and Blood Disorders",
        "Anemia, Neonatal",
        "Hematologic Disease",
        "Infant, Newborn, Diseases"
      ],
      "interventions": [
        {
          "name": "Fetoscopic laser surgery",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Assistance Publique - Hôpitaux de Paris",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 179,
      "start_date": "2011-04-19",
      "completion_date": "2019-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-13",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 8,
      "location_summary": "Aurora, Colorado • Baltimore, Maryland • Cincinnati, Ohio + 5 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01220011"
    },
    {
      "nct_id": "NCT03775954",
      "title": "Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "High Risk Pregnancy",
        "Congenital Heart Disease",
        "Fetal Hydrops",
        "Twin Monochorionic Monoamniotic Placenta",
        "Gastroschisis",
        "Fetal Demise",
        "Stillbirth",
        "Fetal Arrhythmia",
        "Long QT Syndrome",
        "Intrauterine Fetal Death",
        "Sudden Infant Death",
        "Pregnancy Loss",
        "Twin Twin Transfusion Syndrome",
        "Birth Defect",
        "Fetal Cardiac Anomaly",
        "Fetal Cardiac Disorder",
        "Fetal Death",
        "Brugada Syndrome",
        "Fetal Tachycardia"
      ],
      "interventions": [
        {
          "name": "Fetal Magnetocardiogram and Neonatal Electrocardiogram",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "GENETIC"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2018-07-01",
      "completion_date": "2028-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-03-04",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 2,
      "location_summary": "Madison, Wisconsin • Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        },
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03775954"
    },
    {
      "nct_id": "NCT01622049",
      "title": "Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Twin Twin Transfusion Syndrome"
      ],
      "interventions": [
        {
          "name": "Selective Laser Photocoagulation of Communicating Vessels",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 77,
      "start_date": "2006-10",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2013-03-14",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01622049"
    },
    {
      "nct_id": "NCT02122328",
      "title": "Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Twin Twin Transfusion Syndrome"
      ],
      "interventions": [
        {
          "name": "Sequential laser photocoagulation of communicating vessels.",
          "type": "PROCEDURE"
        },
        {
          "name": "Selective laser photocoagulation of communicating vessels",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 55 Years · Female only"
      },
      "enrollment_count": 642,
      "start_date": "2010-06-09",
      "completion_date": "2023-10-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-20",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02122328"
    },
    {
      "nct_id": "NCT04432168",
      "title": "The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Twin Anemia Polycythemia Sequence"
      ],
      "interventions": [
        {
          "name": "Fetoscopic Laser Surgery",
          "type": "PROCEDURE"
        },
        {
          "name": "Standard Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Leiden University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 44,
      "start_date": "2019-04-30",
      "completion_date": "2024-04-30",
      "has_results": false,
      "last_update_posted_date": "2020-06-16",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04432168"
    },
    {
      "nct_id": "NCT05312814",
      "title": "Clinical Utility of the Addition of a SNP-based NIPT Zygosity Determination in Twin Pregnancy Management.",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Twin to Twin Transfusion Syndrome",
        "Pregnancy Complications",
        "Multiple Gestation; Maternal Care"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Natera, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 137,
      "start_date": "2021-10-01",
      "completion_date": "2023-05-15",
      "has_results": false,
      "last_update_posted_date": "2024-09-26",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 8,
      "location_summary": "San Diego, California • Aurora, Colorado • Annapolis, Maryland + 5 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Annapolis",
          "state": "Maryland"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05312814"
    },
    {
      "nct_id": "NCT04140669",
      "title": "Automated Myocardial Performance Index Using Samsung HERA W10",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Twin to Twin Transfusion Syndrome",
        "Congenital Diaphragmatic Hernia",
        "Neural Tube Defects",
        "Lower Urinary Tract Infection"
      ],
      "interventions": [
        {
          "name": "Automated Myocardial Performance Index (MPI)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 7,
      "start_date": "2019-09-16",
      "completion_date": "2020-07-07",
      "has_results": false,
      "last_update_posted_date": "2022-07-13",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04140669"
    },
    {
      "nct_id": "NCT05543499",
      "title": "Database of Monochorionic Pregnancies",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Monochorionic Diamniotic Placenta",
        "Monochorial Monoamniotic Placenta",
        "Twin; Complicating Pregnancy",
        "Twin to Twin Transfusion Syndrome",
        "Twin Reversal Arterial Perfusion Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 1200,
      "start_date": "2022-10-01",
      "completion_date": "2027-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-28",
      "last_synced_at": "2026-07-23T06:43:38.359Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05543499"
    }
  ]
}