{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Upper+Limb+Hypertonia&page=2",
    "query": {
      "condition": "Upper Limb Hypertonia",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Upper+Limb+Hypertonia&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T01:16:16.486Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00280280",
      "title": "Botox vs. Baclofen for Upper Limb Spasticity",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Spasticity"
      ],
      "interventions": [
        {
          "name": "intramuscular Botox versus oral baclofen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2006-02",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2012-01-20",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00280280"
    },
    {
      "nct_id": "NCT04815967",
      "title": "Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Spasticity",
        "Cerebrovascular Accident",
        "Multiple Sclerosis",
        "Traumatic Brain Injury",
        "Cervical Spinal Cord Injury",
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Phase 2; Low Dose MYOBLOC (10,000 Units)",
          "type": "DRUG"
        },
        {
          "name": "Phase 2; High Dose MYOBLOC (20,000 Units)",
          "type": "DRUG"
        },
        {
          "name": "Phase 2; Placebo",
          "type": "DRUG"
        },
        {
          "name": "Phase 3; MYOBLOC",
          "type": "DRUG"
        },
        {
          "name": "Phase 3; Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 32,
      "start_date": "2021-11-02",
      "completion_date": "2023-04-23",
      "has_results": true,
      "last_update_posted_date": "2026-05-27",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 4,
      "location_summary": "Downey, California • Boise, Idaho • Port Royal, South Carolina + 1 more",
      "locations": [
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Boise",
          "state": "Idaho"
        },
        {
          "city": "Port Royal",
          "state": "South Carolina"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04815967"
    },
    {
      "nct_id": "NCT04113525",
      "title": "Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spasticity as Sequela of Stroke",
        "Stroke",
        "Stroke Sequelae",
        "Hemiplegia, Spastic",
        "Hemiparesis",
        "Upper Limb Hypertonia",
        "CVA"
      ],
      "interventions": [
        {
          "name": "MyoRegulator™ System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 13,
      "start_date": "2019-09-24",
      "completion_date": "2022-02-15",
      "has_results": false,
      "last_update_posted_date": "2022-04-14",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 1,
      "location_summary": "Manhasset, New York",
      "locations": [
        {
          "city": "Manhasset",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04113525"
    },
    {
      "nct_id": "NCT03080454",
      "title": "The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Stroke",
        "Cerebrovascular Accident (CVA)",
        "Hemiparesis",
        "Spasticity as Sequela of Stroke",
        "Muscle Spasticity",
        "Upper Extremity Paralysis"
      ],
      "interventions": [
        {
          "name": "sham Doublestim",
          "type": "DEVICE"
        },
        {
          "name": "anodal Doublestim",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2016-09",
      "completion_date": "2018-03",
      "has_results": true,
      "last_update_posted_date": "2021-04-05",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 1,
      "location_summary": "Manhasset, New York",
      "locations": [
        {
          "city": "Manhasset",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03080454"
    },
    {
      "nct_id": "NCT05956509",
      "title": "Study of Intramuscular Injections of ABBV-950 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Spasticity",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Upper Limb Spasticity"
      ],
      "interventions": [
        {
          "name": "ABBV-950",
          "type": "BIOLOGICAL"
        },
        {
          "name": "BOTOX",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo for ABBV-950",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "AbbVie",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 1,
      "start_date": "2024-01-12",
      "completion_date": "2024-06-02",
      "has_results": false,
      "last_update_posted_date": "2024-07-01",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 9,
      "location_summary": "Carlsbad, California • Downey, California • Fresno, California + 6 more",
      "locations": [
        {
          "city": "Carlsbad",
          "state": "California"
        },
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Stamford",
          "state": "Connecticut"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05956509"
    },
    {
      "nct_id": "NCT01603615",
      "title": "BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Pediatrics",
        "Muscle Spasticity",
        "Cerebral Palsy",
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Botulinum Toxin Type A",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 220,
      "start_date": "2012-10-30",
      "completion_date": "2018-09-03",
      "has_results": true,
      "last_update_posted_date": "2019-08-21",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 24,
      "location_summary": "Pasadena, California • Pomona, California • San Diego, California + 19 more",
      "locations": [
        {
          "city": "Pasadena",
          "state": "California"
        },
        {
          "city": "Pomona",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Fairfield",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01603615"
    },
    {
      "nct_id": "NCT05546190",
      "title": "A Study to Collect Participants Experience of Living With Adult Upper Limb (AUL) Spasticity and to Assess the Arm Activity Measure (ArmA)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spastic Hemiparesis",
        "Muscle Spasticity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Ipsen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2022-09-20",
      "completion_date": "2023-03-23",
      "has_results": false,
      "last_update_posted_date": "2023-04-18",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 2,
      "location_summary": "Downey, California • Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Downey",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05546190"
    },
    {
      "nct_id": "NCT07501429",
      "title": "Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Spinal Cord Injury",
        "Spasticity",
        "Shockwave Therapy"
      ],
      "interventions": [
        {
          "name": "Focused extracorporeal shockwave therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2026-04",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-30",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 1,
      "location_summary": "West Orange, New Jersey",
      "locations": [
        {
          "city": "West Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07501429"
    },
    {
      "nct_id": "NCT02334683",
      "title": "Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spasticity",
        "Focal Dystonia",
        "Tremor, Limb"
      ],
      "interventions": [
        {
          "name": "Electrical stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Ultrasound",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2015-10-28",
      "completion_date": "2020-03-03",
      "has_results": true,
      "last_update_posted_date": "2021-11-26",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland • New York, New York",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02334683"
    },
    {
      "nct_id": "NCT00565201",
      "title": "Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Botox and rehab",
          "type": "DRUG"
        },
        {
          "name": "Placebo and rehab",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 25,
      "start_date": "2007-10",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2013-08-13",
      "last_synced_at": "2026-07-23T01:16:16.486Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00565201"
    }
  ]
}