{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Upper+Motor+Neuron+Disease",
    "query": {
      "condition": "Upper Motor Neuron Disease"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 12,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Upper+Motor+Neuron+Disease&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-27T09:23:43.418Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00076687",
      "title": "Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Stroke",
        "Muscle Spasticity",
        "Motor Neuron Disease"
      ],
      "interventions": [
        {
          "name": "botulinum toxin Type A",
          "type": "BIOLOGICAL"
        },
        {
          "name": "saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Allergan",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 155,
      "start_date": "2003-10",
      "completion_date": "2009-08",
      "has_results": true,
      "last_update_posted_date": "2011-10-03",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00076687"
    },
    {
      "nct_id": "NCT02868567",
      "title": "Use of Dalfampridine in Primary Lateral Sclerosis",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Motor Neuron Disease, Upper"
      ],
      "interventions": [
        {
          "name": "dalfampridine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 35,
      "start_date": "2016-03",
      "completion_date": "2026-07",
      "has_results": false,
      "last_update_posted_date": "2025-09-11",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 3,
      "location_summary": "Gainesville, Florida • Boston, Massachusetts • New York, New York",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02868567"
    },
    {
      "nct_id": "NCT06390930",
      "title": "Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Multiple Sclerosis",
        "Multiple Sclerosis, Relapsing-Remitting",
        "Multiple Sclerosis, Secondary Progressive"
      ],
      "interventions": [
        {
          "name": "Acute Intermittent Hypoxia",
          "type": "OTHER"
        },
        {
          "name": "Sham Acute Intermittent Hypoxia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 22,
      "start_date": "2025-02-01",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-02-23",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06390930"
    },
    {
      "nct_id": "NCT05945784",
      "title": "Exploring Accessible Beauty for Individuals With Upper Extremity Deficits",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Stroke, Ischemic",
        "Stroke Hemorrhagic",
        "Stroke (CVA) or TIA",
        "Stroke, Acute",
        "Traumatic Brain Injury",
        "SCI - Spinal Cord Injury",
        "Ehlers-Danlos Syndromes (EDS)",
        "Lupus Erythematosus",
        "Guillain-Barre Syndrome",
        "Multiple Sclerosis",
        "Myasthenia Gravis",
        "Amyotrophic Lateral Sclerosis",
        "Graves Disease",
        "Muscular Dystrophies"
      ],
      "interventions": [
        {
          "name": "Use of Rare Beauty makeup products",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Casa Colina Hospital and Centers for Healthcare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 57,
      "start_date": "2023-07-21",
      "completion_date": "2023-09-29",
      "has_results": false,
      "last_update_posted_date": "2023-12-06",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Pomona, California",
      "locations": [
        {
          "city": "Pomona",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05945784"
    },
    {
      "nct_id": "NCT06384170",
      "title": "Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Pain",
        "Spasticity as Sequela of Stroke",
        "Upper Motor Neuron Lesion"
      ],
      "interventions": [
        {
          "name": "Spinal Cord Stimulation- Closed loop",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2024-12-03",
      "completion_date": "2026-05",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06384170"
    },
    {
      "nct_id": "NCT04798378",
      "title": "NuroSleeve Powered Brace & Stimulation System to Restore Arm Function",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neurologic Diseases",
        "Hemiparesis",
        "Quadriplegia",
        "Muscular Dystrophies",
        "Arthrogryposis",
        "Spinal Cord Injuries",
        "Charcot-Marie-Tooth",
        "Stroke",
        "Weakness of Extremities as Sequela of Stroke",
        "Weakness Due to Upper Motor Neuron Dysfunction",
        "Amyotrophic Lateral Sclerosis",
        "Spinal Muscular Atrophy",
        "Arm Paralysis",
        "Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Neurosleeve",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2020-04-16",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-04-09",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 2,
      "location_summary": "Wilmington, Delaware • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Wilmington",
          "state": "Delaware"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04798378"
    },
    {
      "nct_id": "NCT07151950",
      "title": "Obi Medical Robot: Evaluating Effectiveness Related to Usability",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Upper Extremity Impairments",
        "Cerebral Palsy (CP)",
        "ALS - Amyotrophic Lateral Sclerosis",
        "Rett Syndrome"
      ],
      "interventions": [
        {
          "name": "One-week trial of Obi Medical device, which provides robotic assistance with feeding to persons with upper extremity impairments who are unable to self-feed in the traditional manner using utensils",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Desin LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "5 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2025-05-10",
      "completion_date": "2025-10-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-03",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07151950"
    },
    {
      "nct_id": "NCT01517087",
      "title": "Studying Motor Neuron Tests",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy Subjects",
        "Magnetic Resonance Imaging",
        "Central Nervous System",
        "Volunteer",
        "Neurological Disorder"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "35 Years and older"
      },
      "enrollment_count": 47,
      "start_date": "2012-02-01",
      "completion_date": "2020-11-25",
      "has_results": false,
      "last_update_posted_date": "2021-03-12",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01517087"
    },
    {
      "nct_id": "NCT06300996",
      "title": "Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Muscular Atrophy",
        "Spinal Muscular Atrophy Type 3",
        "Spinal Muscular Atrophy Type II",
        "Spinal Muscular Atrophy 4",
        "SMA"
      ],
      "interventions": [
        {
          "name": "Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Marco Capogrosso",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "16 Years to 65 Years"
      },
      "enrollment_count": 3,
      "start_date": "2024-05-31",
      "completion_date": "2029-09",
      "has_results": false,
      "last_update_posted_date": "2025-08-26",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06300996"
    },
    {
      "nct_id": "NCT02408900",
      "title": "Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Muscle Spasticity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 15,
      "start_date": "2015-03-25",
      "completion_date": "2015-08-03",
      "has_results": false,
      "last_update_posted_date": "2019-12-17",
      "last_synced_at": "2026-06-27T09:23:43.418Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02408900"
    }
  ]
}