{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Uremic+Pruritus", "query": { "condition": "Uremic Pruritus" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 14, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Uremic+Pruritus&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-23T15:05:38.194Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02143648", "title": "Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Uremic Pruritus", "Pruritus" ], "interventions": [ { "name": "nalbuphine HCl ER tablets 60 mg BID", "type": "DRUG" }, { "name": "nalbuphine HCl ER tablets 120mg BID", "type": "DRUG" }, { "name": "Placebo tablets BID", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Trevi Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 373, "start_date": "2014-06", "completion_date": "2015-07", "has_results": true, "last_update_posted_date": "2025-05-21", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 35 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Pine Bluff", "state": "Arkansas" }, { "city": "Azusa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02143648" }, { "nct_id": "NCT02229929", "title": "Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Pruritus", "Uremic Pruritus" ], "interventions": [ { "name": "Part A: Placebo", "type": "DRUG" }, { "name": "Part A: CR845 0.5 mcg/kg", "type": "DRUG" }, { "name": "Part A: CR845 1.0 mcg/kg", "type": "DRUG" }, { "name": "Part A: CR845 2.5 mcg/kg", "type": "DRUG" }, { "name": "Part B: Placebo", "type": "DRUG" }, { "name": "Part B: CR845 1.0 mcg/kg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 89, "start_date": "2014-07", "completion_date": "2015-07", "has_results": false, "last_update_posted_date": "2016-08-10", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 20, "location_summary": "Pine Bluff, Arkansas • Chula Vista, California • Long Beach, California + 17 more", "locations": [ { "city": "Pine Bluff", "state": "Arkansas" }, { "city": "Chula Vista", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Northridge", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02229929" }, { "nct_id": "NCT03422653", "title": "A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uremic Pruritus" ], "interventions": [ { "name": "CR845 0.5 mcg/kg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 378, "start_date": "2018-02-20", "completion_date": "2020-03-26", "has_results": true, "last_update_posted_date": "2022-04-26", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 57, "location_summary": "Homewood, Alabama • Huntsville, Alabama • Bakersfield, California + 52 more", "locations": [ { "city": "Homewood", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Bakersfield", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03422653" }, { "nct_id": "NCT02143973", "title": "Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Uremic Pruritus", "Pruritus" ], "interventions": [ { "name": "nalbuphine HCl ER", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Trevi Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 167, "start_date": "2014-09", "completion_date": "2016-01", "has_results": true, "last_update_posted_date": "2025-05-21", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 35, "location_summary": "Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 29 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Pine Bluff", "state": "Arkansas" }, { "city": "Azusa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02143973" }, { "nct_id": "NCT03998163", "title": "CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uremic Pruritus" ], "interventions": [ { "name": "CR845 0.5 mcg/kg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 222, "start_date": "2019-05-06", "completion_date": "2020-03-06", "has_results": true, "last_update_posted_date": "2021-10-15", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 33, "location_summary": "Escondido, California • Riverside, California • San Diego, California + 26 more", "locations": [ { "city": "Escondido", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Victorville", "state": "California" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03998163" }, { "nct_id": "NCT03636269", "title": "CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Uremic Pruritus" ], "interventions": [ { "name": "CR845 0.5 mcg/kg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 473, "start_date": "2018-07-17", "completion_date": "2020-03-30", "has_results": true, "last_update_posted_date": "2022-04-26", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 29, "location_summary": "Chula Vista, California • Fountain Valley, California • Northridge, California + 25 more", "locations": [ { "city": "Chula Vista", "state": "California" }, { "city": "Fountain Valley", "state": "California" }, { "city": "Northridge", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Dimas", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03636269" }, { "nct_id": "NCT02696499", "title": "Treatment of Uremic Pruritus With PA101B", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Uremic Pruritus" ], "interventions": [ { "name": "PA101B", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Patara Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 70, "start_date": "2016-02", "completion_date": "2016-12", "has_results": false, "last_update_posted_date": "2018-04-20", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 13, "location_summary": "Phoenix, Arizona • Pine Bluff, Arkansas • Northridge, California + 10 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Pine Bluff", "state": "Arkansas" }, { "city": "Northridge", "state": "California" }, { "city": "San Dimas", "state": "California" }, { "city": "Pembroke Pines", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02696499" }, { "nct_id": "NCT05356403", "title": "CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Kidney Diseases", "Pruritus" ], "interventions": [ { "name": "Difelikefalin 1 mg Oral Tablet", "type": "DRUG" }, { "name": "Placebo Oral Tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 105, "start_date": "2022-08-26", "completion_date": "2024-02-26", "has_results": false, "last_update_posted_date": "2024-05-07", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 9, "location_summary": "Northridge, California • Miami, Florida • Miami Lakes, Florida + 5 more", "locations": [ { "city": "Northridge", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami Lakes", "state": "Florida" }, { "city": "Miami Lakes", "state": "Florida" }, { "city": "Weston", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05356403" }, { "nct_id": "NCT05342623", "title": "A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Kidney Diseases", "Pruritus" ], "interventions": [ { "name": "Difelikefalin 1 mg Oral Tablet", "type": "DRUG" }, { "name": "Placebo Oral Tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cara Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 286, "start_date": "2022-05-17", "completion_date": "2024-02-29", "has_results": false, "last_update_posted_date": "2024-05-07", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 83, "location_summary": "Huntsville, Alabama • Phoenix, Arizona • Surprise, Arizona + 76 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Surprise", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Bakersfield", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05342623" }, { "nct_id": "NCT00693654", "title": "Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pruritis" ], "interventions": [ { "name": "Sarna", "type": "DRUG" }, { "name": "Cetaphil", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Wake Forest University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 28, "start_date": "2006-11", "completion_date": "2008-10", "has_results": true, "last_update_posted_date": "2018-09-10", "last_synced_at": "2026-07-23T15:05:38.194Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00693654" } ] }