{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Vascular+Stiffness",
    "query": {
      "condition": "Vascular Stiffness"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 133,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Vascular+Stiffness&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T00:04:55.230Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01692301",
      "title": "Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "LCZ696",
          "type": "DRUG"
        },
        {
          "name": "Olmesartan",
          "type": "DRUG"
        },
        {
          "name": "LCZ696 matching placebo",
          "type": "DRUG"
        },
        {
          "name": "Olmesartan matching placebo",
          "type": "DRUG"
        },
        {
          "name": "amlodipine",
          "type": "DRUG"
        },
        {
          "name": "hydrochlorothiazide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Novartis Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 454,
      "start_date": "2012-12",
      "completion_date": "2015-04",
      "has_results": true,
      "last_update_posted_date": "2016-05-04",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 11,
      "location_summary": "Clearwater, Florida • Chicago, Illinois • Baltimore, Maryland + 8 more",
      "locations": [
        {
          "city": "Clearwater",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Belzoni",
          "state": "Mississippi"
        },
        {
          "city": "Jackson",
          "state": "Mississippi"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01692301"
    },
    {
      "nct_id": "NCT03617302",
      "title": "Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Aging",
        "Arterial Stiffness",
        "Endothelial Dysfunction",
        "Hypertension",
        "Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "Experimental: Nitrate-containing",
          "type": "DRUG"
        },
        {
          "name": "Placebo: Nitrate-depleted",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gary L. Pierce, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "50 Years to 79 Years"
      },
      "enrollment_count": 16,
      "start_date": "2018-11-01",
      "completion_date": "2024-06-30",
      "has_results": true,
      "last_update_posted_date": "2026-03-04",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03617302"
    },
    {
      "nct_id": "NCT07158047",
      "title": "Repeated Far Infrared Sauna Bathing in Adults With Obesity",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity (Disorder)"
      ],
      "interventions": [
        {
          "name": "Heat therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Oregon",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 20,
      "start_date": "2022-03-07",
      "completion_date": "2026-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-04",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Eugene, Oregon",
      "locations": [
        {
          "city": "Eugene",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07158047"
    },
    {
      "nct_id": "NCT01041547",
      "title": "Vascular Function, Insulin Sensitivity, and Vitamin D",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Insulin Sensitivity",
        "Flow-mediated Dilation",
        "Arterial Stiffness"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "19 Years to 60 Years"
      },
      "enrollment_count": 63,
      "start_date": "2009-12",
      "completion_date": "2013-12",
      "has_results": false,
      "last_update_posted_date": "2014-01-14",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01041547"
    },
    {
      "nct_id": "NCT01776151",
      "title": "Arterial Elasticity: A Substudy of Strategic Timing of AntiRetroviral Treatment (START)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cardiovascular Diseases",
        "HIV"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 337,
      "start_date": "2009-04-15",
      "completion_date": "2015-09",
      "has_results": false,
      "last_update_posted_date": "2023-03-21",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01776151"
    },
    {
      "nct_id": "NCT07483177",
      "title": "HEART: Pilot Randomized Controlled Trial",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Thoracic Aortic Aneurysm"
      ],
      "interventions": [
        {
          "name": "Spironolactone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2026-05",
      "completion_date": "2028-05",
      "has_results": false,
      "last_update_posted_date": "2026-03-19",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07483177"
    },
    {
      "nct_id": "NCT05365607",
      "title": "NightWare and Cardiovascular Health in Adults With PTSD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorder",
        "Cardiovascular Diseases",
        "Autonomic Dysfunction",
        "Vascular Stiffness",
        "Nightmare",
        "Endothelial Dysfunction"
      ],
      "interventions": [
        {
          "name": "NightWare",
          "type": "DEVICE"
        },
        {
          "name": "Sham NightWare",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "22 Years to 99 Years"
      },
      "enrollment_count": 40,
      "start_date": "2022-06-24",
      "completion_date": "2024-08-18",
      "has_results": false,
      "last_update_posted_date": "2024-10-08",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 2,
      "location_summary": "Aurora, Colorado • Denver, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05365607"
    },
    {
      "nct_id": "NCT02122198",
      "title": "Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Impairment",
        "Executive Dysfunction",
        "Endothelial Dysfunction",
        "Cardiovascular Disease"
      ],
      "interventions": [
        {
          "name": "Leuprolide acetate",
          "type": "DRUG"
        },
        {
          "name": "Estradiol",
          "type": "DRUG"
        },
        {
          "name": "Medroxyprogesterone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "40 Years to 60 Years · Female only"
      },
      "enrollment_count": 17,
      "start_date": "2014-09-08",
      "completion_date": "2017-09-15",
      "has_results": true,
      "last_update_posted_date": "2022-01-10",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 2,
      "location_summary": "Aurora, Colorado • Boulder, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Boulder",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02122198"
    },
    {
      "nct_id": "NCT01472692",
      "title": "Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Prehypertension",
        "Gout",
        "Pulse Wave Velocity",
        "Hypertension",
        "24 Hour Blood Pressure"
      ],
      "interventions": [
        {
          "name": "Febuxostat",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 47,
      "start_date": "2011-10",
      "completion_date": "2014-03",
      "has_results": true,
      "last_update_posted_date": "2019-12-16",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01472692"
    },
    {
      "nct_id": "NCT04001647",
      "title": "Targeting ER Stress in Vascular Dysfunction",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Vasodilation",
        "Arterial Stiffness"
      ],
      "interventions": [
        {
          "name": "Acetylcholine",
          "type": "DRUG"
        },
        {
          "name": "Sodium Nitroprusside",
          "type": "DRUG"
        },
        {
          "name": "Ascorbic Acid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Colorado State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 17,
      "start_date": "2019-06-01",
      "completion_date": "2022-08-16",
      "has_results": false,
      "last_update_posted_date": "2025-04-08",
      "last_synced_at": "2026-05-22T00:04:55.230Z",
      "location_count": 1,
      "location_summary": "Fort Collins, Colorado",
      "locations": [
        {
          "city": "Fort Collins",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04001647"
    }
  ]
}