{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Vasoconstriction",
    "query": {
      "condition": "Vasoconstriction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 28,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Vasoconstriction&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T20:42:46.388Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00839605",
      "title": "Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Esophageal Cancer",
        "Lung Cancer",
        "Chest Wall Disorders"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Missouri-Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2009-03",
      "completion_date": "2009-11",
      "has_results": false,
      "last_update_posted_date": "2016-10-04",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Columbia, Missouri",
      "locations": [
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00839605"
    },
    {
      "nct_id": "NCT03150524",
      "title": "RCVS: The Rational Approach to Diagnosis and Treatment",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Reversible Cerebral Vasoconstriction Syndrome"
      ],
      "interventions": [
        {
          "name": "TCD- cerebral blood flow velocities",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Headache pain score",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Neurological examination",
          "type": "OTHER"
        },
        {
          "name": "Repeat Neuroimaging",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Nimodipine",
          "type": "DRUG"
        },
        {
          "name": "Verapamil ER",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "BEHAVIORAL",
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2017-07-01",
      "completion_date": "2019-05-31",
      "has_results": false,
      "last_update_posted_date": "2019-09-18",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03150524"
    },
    {
      "nct_id": "NCT00708565",
      "title": "Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypoxic Pulmonary Vasoconstriction"
      ],
      "interventions": [
        {
          "name": "iloprost",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "VA Loma Linda Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "MALE",
        "summary": "18 Years to 80 Years · Male only"
      },
      "enrollment_count": 50,
      "start_date": "2008-07",
      "completion_date": "2008-10",
      "has_results": false,
      "last_update_posted_date": "2008-07-02",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Loma Linda, California",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00708565"
    },
    {
      "nct_id": "NCT03684213",
      "title": "Local Antioxidant Therapy Vasoconstriction Effects in Different Races",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cardiovascular Diseases",
        "Cardiovascular Risk Factor",
        "Vasoconstriction"
      ],
      "interventions": [
        {
          "name": "Control (Norepinephrine)",
          "type": "DRUG"
        },
        {
          "name": "Norepinephrine + Ascorbic Acid",
          "type": "DRUG"
        },
        {
          "name": "Norepinephrine + L-NAME",
          "type": "DRUG"
        },
        {
          "name": "Norepinephrine + L-NAME + Ascorbic Acid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas at Arlington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 22,
      "start_date": "2018-10-15",
      "completion_date": "2024-06-08",
      "has_results": false,
      "last_update_posted_date": "2024-06-11",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Arlington, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03684213"
    },
    {
      "nct_id": "NCT03733470",
      "title": "Hypoxic Pulmonary Vasoconstriction Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Emphysema"
      ],
      "interventions": [
        {
          "name": "Sildenafil study group",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eric A. Hoffman",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "30 Years to 60 Years"
      },
      "enrollment_count": 22,
      "start_date": "2011-06-29",
      "completion_date": "2014-01-13",
      "has_results": true,
      "last_update_posted_date": "2019-10-01",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03733470"
    },
    {
      "nct_id": "NCT01210430",
      "title": "Local Vasoconstriction in Postural Tachycardia Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Postural Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "Losartan",
          "type": "DRUG"
        },
        {
          "name": "Ascorbic Acid (Vitamin C)",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York Medical College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "14 Years to 29 Years"
      },
      "enrollment_count": 74,
      "start_date": "2010-07",
      "completion_date": "2015-06",
      "has_results": false,
      "last_update_posted_date": "2021-06-10",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Hawthorne, New York",
      "locations": [
        {
          "city": "Hawthorne",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01210430"
    },
    {
      "nct_id": "NCT00864240",
      "title": "The Dose-response \"Pilot\" Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Clobex TM (Clobetasol) 0.05% Lotion, single exposure",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Actavis Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 15,
      "start_date": "2005-10",
      "completion_date": "2005-10",
      "has_results": false,
      "last_update_posted_date": "2019-07-09",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00864240"
    },
    {
      "nct_id": "NCT05146089",
      "title": "Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Sleep Apnea",
        "Healthy",
        "Vasoconstriction",
        "Vasodilation"
      ],
      "interventions": [
        {
          "name": "Hypoxic exposure",
          "type": "OTHER"
        },
        {
          "name": "modified Oxford test",
          "type": "OTHER"
        },
        {
          "name": "Oral Bosentan 62.5 mg",
          "type": "DRUG"
        },
        {
          "name": "Hypoxic ventilatory response test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University of Missouri-Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 54,
      "start_date": "2016-12-20",
      "completion_date": "2021-04-12",
      "has_results": false,
      "last_update_posted_date": "2021-12-06",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 2,
      "location_summary": "Columbia, Missouri • Rochester, Missouri",
      "locations": [
        {
          "city": "Columbia",
          "state": "Missouri"
        },
        {
          "city": "Rochester",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05146089"
    },
    {
      "nct_id": "NCT03680404",
      "title": "The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cardiovascular Diseases",
        "Cardiovascular Risk Factor",
        "Vasoconstriction"
      ],
      "interventions": [
        {
          "name": "Control (Phenylephrine)",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Apocynin",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Allopurinol",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Tempol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas at Arlington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 24,
      "start_date": "2018-10-01",
      "completion_date": "2020-02-01",
      "has_results": false,
      "last_update_posted_date": "2020-11-05",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Arlington, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03680404"
    },
    {
      "nct_id": "NCT04358770",
      "title": "Bio-equivalence Vasoconstriction Activity Study for Topically Applied Clocortolone Pivalate 0.1% Cream",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Bioequivalence Study"
      ],
      "interventions": [
        {
          "name": "Clocortolone Pivalate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Sun Pharmaceutical Industries, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 124,
      "start_date": "2018-03-02",
      "completion_date": "2018-05-11",
      "has_results": false,
      "last_update_posted_date": "2020-04-24",
      "last_synced_at": "2026-06-10T20:42:46.388Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04358770"
    }
  ]
}