{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Venous+Reflux",
    "query": {
      "condition": "Venous Reflux"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Venous+Reflux&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T05:37:54.070Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04225806",
      "title": "Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-US)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Venous Insufficiency (CVI)",
        "Deep Vein Reflux"
      ],
      "interventions": [
        {
          "name": "BlueLeaf® Endovenous Valve Formation System (BlueLeaf System)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Intervene, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2020-02-13",
      "completion_date": "2023-09-30",
      "has_results": true,
      "last_update_posted_date": "2025-08-19",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 5,
      "location_summary": "Darien, Connecticut • New York, New York • Chapel Hill, North Carolina + 2 more",
      "locations": [
        {
          "city": "Darien",
          "state": "Connecticut"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Norfolk",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04225806"
    },
    {
      "nct_id": "NCT06811909",
      "title": "Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Non-infected Venous Leg Ulcer",
        "Venous Leg Ulcer",
        "Venous Insufficiency",
        "Venous Stasis",
        "Venous Reflux"
      ],
      "interventions": [
        {
          "name": "BR-AC",
          "type": "OTHER"
        },
        {
          "name": "Standard Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "BioStem Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2025-02-14",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2026-01-23",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 23,
      "location_summary": "Guntersville, Alabama • Castro Valley, California • Glendale, California + 17 more",
      "locations": [
        {
          "city": "Guntersville",
          "state": "Alabama"
        },
        {
          "city": "Castro Valley",
          "state": "California"
        },
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06811909"
    },
    {
      "nct_id": "NCT00509392",
      "title": "ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Venous Reflux"
      ],
      "interventions": [
        {
          "name": "Seg. RF Ablation & ClosureFAST catheter",
          "type": "DEVICE"
        },
        {
          "name": "Endovenous Laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Endovascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 69,
      "start_date": "2007-03",
      "completion_date": "2008-01",
      "has_results": true,
      "last_update_posted_date": "2017-07-12",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00509392"
    },
    {
      "nct_id": "NCT01549860",
      "title": "Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Venous Insufficiency",
        "Venous Reflux",
        "Lower Extremity Ulcer"
      ],
      "interventions": [
        {
          "name": "MIST Therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Celleration, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 156,
      "start_date": "2012-04",
      "completion_date": "2015-04",
      "has_results": true,
      "last_update_posted_date": "2015-07-30",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Weymouth, Massachusetts",
      "locations": [
        {
          "city": "Weymouth",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01549860"
    },
    {
      "nct_id": "NCT03455699",
      "title": "VeClose Five Year Follow-Up Extension Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Great Saphenous Vein (GSV) With Venous Reflux Disease"
      ],
      "interventions": [
        {
          "name": "VenaSeal SCS",
          "type": "DEVICE"
        },
        {
          "name": "ClosureFast Radiofrequency Ablation (RFA)",
          "type": "DEVICE"
        },
        {
          "name": "Roll-In (VenaSeal SCS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Endovascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 114,
      "start_date": "2016-07",
      "completion_date": "2019-01",
      "has_results": false,
      "last_update_posted_date": "2019-04-12",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 9,
      "location_summary": "Scottsdale, Arizona • San Diego, California • Greenwood Village, Colorado + 6 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Greenwood Village",
          "state": "Colorado"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Hunt Valley",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03455699"
    },
    {
      "nct_id": "NCT01428076",
      "title": "Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Varicose Veins"
      ],
      "interventions": [
        {
          "name": "Polidocanol Endovenous Microfoam (PEM)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Scientific Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 21,
      "start_date": "2011-08",
      "completion_date": "2012-01",
      "has_results": true,
      "last_update_posted_date": "2021-04-21",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Bradenton, Florida",
      "locations": [
        {
          "city": "Bradenton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01428076"
    },
    {
      "nct_id": "NCT04006184",
      "title": "Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Varicose Veins",
        "Venous Reflux",
        "Venous Insufficiency"
      ],
      "interventions": [
        {
          "name": "Chart review",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Lake Washington Vascular",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 547,
      "start_date": "2019-06-14",
      "completion_date": "2019-08-30",
      "has_results": false,
      "last_update_posted_date": "2019-10-03",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Bellevue, Washington",
      "locations": [
        {
          "city": "Bellevue",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04006184"
    },
    {
      "nct_id": "NCT00618514",
      "title": "The BRILLIANT Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Varicose Veins"
      ],
      "interventions": [
        {
          "name": "Bright Tip Laser Fiber",
          "type": "DEVICE"
        },
        {
          "name": "Bare Tip Laser Fiber",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vascular Solutions LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 93,
      "start_date": "2008-06",
      "completion_date": "2009-08",
      "has_results": true,
      "last_update_posted_date": "2015-03-23",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 7,
      "location_summary": "Dothan, Alabama • Scottsdale, Arizona • Hollywood, Florida + 4 more",
      "locations": [
        {
          "city": "Dothan",
          "state": "Alabama"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Palm Harbor",
          "state": "Florida"
        },
        {
          "city": "Kinston",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00618514"
    },
    {
      "nct_id": "NCT02988063",
      "title": "Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Leg Ulcer",
        "Veins, Varicose",
        "Venous Ulcer",
        "Reflux",
        "Venous Reflux",
        "Venous Leg Ulcer",
        "Varicose Veins",
        "Varicose Ulcer",
        "Varicose Veins Leg"
      ],
      "interventions": [
        {
          "name": "Polidocanol Endovenous Microfoam (PEM)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "OhioHealth",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2017-04-10",
      "completion_date": "2017-09-12",
      "has_results": false,
      "last_update_posted_date": "2017-09-15",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02988063"
    },
    {
      "nct_id": "NCT02936271",
      "title": "Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Venous Insufficiency of Leg",
        "Venous Reflux",
        "Varicose Veins",
        "Lower Extremity Edema Chronic"
      ],
      "interventions": [
        {
          "name": "Vasculera",
          "type": "OTHER"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Corewell Health West",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 0,
      "start_date": "2016-10",
      "completion_date": "2017-04-01",
      "has_results": false,
      "last_update_posted_date": "2022-11-23",
      "last_synced_at": "2026-05-22T05:37:54.070Z",
      "location_count": 1,
      "location_summary": "Grand Rapids, Michigan",
      "locations": [
        {
          "city": "Grand Rapids",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02936271"
    }
  ]
}