{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=White+Matter+Alterations",
    "query": {
      "condition": "White Matter Alterations"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T03:06:37.321Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01952028",
      "title": "LAMA2-related Muscular Dystrophy Brain Study",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Cure CMD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 0,
      "start_date": "2013-11",
      "completion_date": "2014-12",
      "has_results": false,
      "last_update_posted_date": "2018-03-07",
      "last_synced_at": "2026-05-22T03:06:37.321Z",
      "location_count": 1,
      "location_summary": "San Pedro, California",
      "locations": [
        {
          "city": "San Pedro",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01952028"
    },
    {
      "nct_id": "NCT05491980",
      "title": "Florida Cerebrovascular Disease Biorepository and Genomics Center",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebrovascular Disease",
        "Ischemic Stroke",
        "Transient Ischemic Attack",
        "Intracerebral Hemorrhage",
        "Aneurysmal Subarachnoid Hemorrhage",
        "Vascular Dementia",
        "Anoxic Brain Injury",
        "Unruptured Intracranial Aneurysm",
        "Carotid Artery Stenosis Symptomatic",
        "Asymptomatic Carotid Artery Stenosis",
        "Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage",
        "Cerebral Venous Thrombosis",
        "Moyamoya Disease",
        "Fibromuscular Dysplasia",
        "Subarachnoid Hemorrhage",
        "Leukoaraiosis",
        "Arteriovenous Fistula",
        "Reversible Cerebral Vasoconstriction Syndrome",
        "CADASIL"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2022-08-02",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-05-22T03:06:37.321Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05491980"
    },
    {
      "nct_id": "NCT04073966",
      "title": "MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Brain Metastases",
        "Neurocognitive Deficit",
        "White Matter Alterations",
        "Radiation Exposure"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "UNC Lineberger Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2019-12-04",
      "completion_date": "2026-09-15",
      "has_results": false,
      "last_update_posted_date": "2025-09-19",
      "last_synced_at": "2026-05-22T03:06:37.321Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04073966"
    },
    {
      "nct_id": "NCT05848271",
      "title": "Natural History Study of Patients with HPDL Mutations",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mitochondrial Encephalomyopathies",
        "Hereditary Spastic Paraplegia",
        "Spastic Paraplegia",
        "White Matter Disease",
        "Neonatal Encephalopathy",
        "Mutation",
        "Genetic Disease"
      ],
      "interventions": [
        {
          "name": "Patient Registry",
          "type": "OTHER"
        },
        {
          "name": "Dry blood spots sampling",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 50,
      "start_date": "2023-05-18",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-03-30",
      "last_synced_at": "2026-05-22T03:06:37.321Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05848271"
    },
    {
      "nct_id": "NCT02169739",
      "title": "Remote Preconditioning Over Time To Empower Cerebral Tissue",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ischemic Stroke",
        "Cerebral Small Vessel Disease",
        "Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "Ischemic Preconditioning",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2015-11",
      "completion_date": "2020-03",
      "has_results": true,
      "last_update_posted_date": "2021-03-10",
      "last_synced_at": "2026-05-22T03:06:37.321Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02169739"
    }
  ]
}