{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=White+Matter+Injury",
    "query": {
      "condition": "White Matter Injury"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-21T23:34:51.845Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01936246",
      "title": "Protein Supplementation in Infants With Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Perinatal Stroke",
        "Hypoxic-ischemic Encephalopathy",
        "White Matter Injury"
      ],
      "interventions": [
        {
          "name": "Increased protein",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Days",
        "maximum_age": "3 Weeks",
        "sex": "ALL",
        "summary": "2 Days to 3 Weeks"
      },
      "enrollment_count": 24,
      "start_date": "2012-08",
      "completion_date": "2016-02",
      "has_results": false,
      "last_update_posted_date": "2017-07-06",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01936246"
    },
    {
      "nct_id": "NCT02006407",
      "title": "A Pilot Study to Evaluate Neurocognitive Injury and Longitudinal Changes in White Matter During Radiation Therapy in Children With Primary Brain Tumors",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Tumor, Primary"
      ],
      "interventions": [
        {
          "name": "Cranial Radiotherapy",
          "type": "RADIATION"
        },
        {
          "name": "MRI with Diffusion Tensor Imaging (DTI)",
          "type": "DEVICE"
        },
        {
          "name": "Neuro-cognitive Testing (CogState)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "RADIATION",
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Michigan Rogel Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "6 Years to 21 Years"
      },
      "enrollment_count": 5,
      "start_date": "2013-06",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2016-12-30",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02006407"
    },
    {
      "nct_id": "NCT01984476",
      "title": "Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spinal Cord Injury"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "James J. Peters Veterans Affairs Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "25 Years to 65 Years"
      },
      "enrollment_count": 120,
      "start_date": "2013-07",
      "completion_date": "2017-07",
      "has_results": false,
      "last_update_posted_date": "2017-10-17",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "West Orange, New Jersey",
      "locations": [
        {
          "city": "West Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01984476"
    },
    {
      "nct_id": "NCT03023163",
      "title": "A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spinal Cord Injury"
      ],
      "interventions": [
        {
          "name": "Longitudinal",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "James J. Peters Veterans Affairs Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "28 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "28 Years to 75 Years"
      },
      "enrollment_count": 92,
      "start_date": "2016-12",
      "completion_date": "2022-12",
      "has_results": false,
      "last_update_posted_date": "2023-06-26",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "West Orange, New Jersey",
      "locations": [
        {
          "city": "West Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03023163"
    },
    {
      "nct_id": "NCT07688746",
      "title": "Neonatal White Matter Injury Trial (WRAP)",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "White Matter Injury",
        "Brain Injury, Fetus and Neonate",
        "Neonatal Brain Injury",
        "Periventricular Leukomalacia",
        "Periventricular White Matter Abnormalities"
      ],
      "interventions": [
        {
          "name": "Clemastine fumarate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bridget LaMonica Ostrem, M.D., Ph.D.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Weeks",
        "maximum_age": "20 Weeks",
        "sex": "ALL",
        "summary": "3 Weeks to 20 Weeks"
      },
      "enrollment_count": 24,
      "start_date": "2026-07-01",
      "completion_date": "2031-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-07",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07688746"
    },
    {
      "nct_id": "NCT00280306",
      "title": "White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Spinal Cord Compression"
      ],
      "interventions": [
        {
          "name": "No interventions",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2005-11",
      "completion_date": "2008-10",
      "has_results": false,
      "last_update_posted_date": "2015-06-04",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00280306"
    },
    {
      "nct_id": "NCT07275021",
      "title": "Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Preterm Less Than 32wks With IVH, WMI/PVL",
        "Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE"
      ],
      "interventions": [
        {
          "name": "Prospective Clinical and Neurodevelopmental Data Collection",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "31 Weeks",
        "maximum_age": "42 Weeks",
        "sex": "ALL",
        "summary": "31 Weeks to 42 Weeks"
      },
      "enrollment_count": 60,
      "start_date": "2025-07-07",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-12-10",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07275021"
    },
    {
      "nct_id": "NCT02008045",
      "title": "MR Imaging of Perinatal Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Perinatal White Matter Brain Injury"
      ],
      "interventions": [
        {
          "name": "Magnetic Resonance Imaging",
          "type": "DEVICE"
        },
        {
          "name": "Neurodevelopmental Testing",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "7 Years",
        "sex": "ALL",
        "summary": "1 Day to 7 Years"
      },
      "enrollment_count": 557,
      "start_date": "2009-07-01",
      "completion_date": "2025-06-02",
      "has_results": false,
      "last_update_posted_date": "2026-01-13",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02008045"
    },
    {
      "nct_id": "NCT00724594",
      "title": "Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Chorioamnionitis",
        "Brain Injury"
      ],
      "interventions": [
        {
          "name": "N-acetylcysteine",
          "type": "DRUG"
        },
        {
          "name": "Control",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "13 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2008-08",
      "completion_date": "2014-08",
      "has_results": true,
      "last_update_posted_date": "2021-04-12",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00724594"
    },
    {
      "nct_id": "NCT00940615",
      "title": "The Effect of Aerobic Exercise on Mild Traumatic Brain Injury",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "aerobic exercise",
          "type": "OTHER"
        },
        {
          "name": "stretching/toning",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "US Department of Veterans Affairs",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 24,
      "start_date": "2009-09",
      "completion_date": "2010-09",
      "has_results": false,
      "last_update_posted_date": "2015-06-26",
      "last_synced_at": "2026-07-21T23:34:51.845Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00940615"
    }
  ]
}