{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Wrinkles&page=4",
    "query": {
      "condition": "Wrinkles",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 278,
    "total_pages": 28,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Wrinkles&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Wrinkles&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-21T03:07:44.555Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04162496",
      "title": "Restylane Refyne for Correction of Horizontal Neck Rhytides",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aging",
        "Wrinkle",
        "Rhytides"
      ],
      "interventions": [
        {
          "name": "Restylane Refyne",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Siperstein Dermatology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2020-08-11",
      "completion_date": "2021-11-30",
      "has_results": true,
      "last_update_posted_date": "2026-07-16",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "Boynton Beach, Florida",
      "locations": [
        {
          "city": "Boynton Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04162496"
    },
    {
      "nct_id": "NCT03409965",
      "title": "Lutronic Infini and LaseMD Systems in Combination Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Face and Neck Wrinkles, Texture, Pigmentation"
      ],
      "interventions": [
        {
          "name": "Lutronic Infini System",
          "type": "DEVICE"
        },
        {
          "name": "Lutronic LaseMD System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "CynosureLutronic",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2017-12-08",
      "completion_date": "2018-08-21",
      "has_results": false,
      "last_update_posted_date": "2018-08-23",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 2,
      "location_summary": "Vista, California • Santa Rosa Beach, Florida",
      "locations": [
        {
          "city": "Vista",
          "state": "California"
        },
        {
          "city": "Santa Rosa Beach",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03409965"
    },
    {
      "nct_id": "NCT06724900",
      "title": "A Study Assessing KB304 for the Treatment of Wrinkles in Women",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Wrinkles in Decolletage",
        "Pigmentation",
        "Décolleté Wrinkles"
      ],
      "interventions": [
        {
          "name": "KB304",
          "type": "BIOLOGICAL"
        },
        {
          "name": "0.9% Normal Saline (NS)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "Krystal Biotech, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 75 Years · Female only"
      },
      "enrollment_count": 19,
      "start_date": "2024-11-20",
      "completion_date": "2025-08",
      "has_results": false,
      "last_update_posted_date": "2025-05-13",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "Newport Beach, California",
      "locations": [
        {
          "city": "Newport Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06724900"
    },
    {
      "nct_id": "NCT00876265",
      "title": "Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Belotero",
          "type": "DEVICE"
        },
        {
          "name": "Zyplast",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Merz North America, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 118,
      "start_date": "2006-12",
      "completion_date": "2008-12",
      "has_results": true,
      "last_update_posted_date": "2013-04-26",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Metairie",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00876265"
    },
    {
      "nct_id": "NCT05011461",
      "title": "The Effect of Topical Almond Oil vs. Topical Retinol on The Appearance of Facial Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkles",
        "Skin"
      ],
      "interventions": [
        {
          "name": "Almond Oil",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "40 Years and older · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2021-05-17",
      "completion_date": "2022-10-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-14",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05011461"
    },
    {
      "nct_id": "NCT03776461",
      "title": "Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Rhytides",
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "Venus Viva",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Venus Concept",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2019-03-08",
      "completion_date": "2021-06-18",
      "has_results": true,
      "last_update_posted_date": "2023-08-15",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03776461"
    },
    {
      "nct_id": "NCT01950065",
      "title": "Effectiveness and Safety Study of the Iovera Device for the Temporary Reduction in the Appearance of Forehead Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Forehead Wrinkles"
      ],
      "interventions": [
        {
          "name": "iovera",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Pacira Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 85,
      "start_date": "2013-09",
      "completion_date": "2014-10",
      "has_results": false,
      "last_update_posted_date": "2015-03-24",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 6,
      "location_summary": "Roseville, California • Chicago, Illinois • Chestnut Hill, Massachusetts + 3 more",
      "locations": [
        {
          "city": "Roseville",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01950065"
    },
    {
      "nct_id": "NCT07421544",
      "title": "Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Fine Lines",
        "Wrinkle",
        "Facial Laxity",
        "Volume Loss"
      ],
      "interventions": [
        {
          "name": "Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "30 Years to 75 Years"
      },
      "enrollment_count": 100,
      "start_date": "2026-03-01",
      "completion_date": "2026-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07421544"
    },
    {
      "nct_id": "NCT00884234",
      "title": "Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lateral Canthal Lines"
      ],
      "interventions": [
        {
          "name": "Vehicle Control",
          "type": "OTHER"
        },
        {
          "name": "RT001 (Botulinum Toxin Type A Topical Gel)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Revance Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "30 Years to 55 Years"
      },
      "enrollment_count": 30,
      "start_date": "2009-02",
      "completion_date": "2009-06",
      "has_results": false,
      "last_update_posted_date": "2020-08-28",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00884234"
    },
    {
      "nct_id": "NCT04754646",
      "title": "RHA® 4 NLF Cannula",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Nasolabial Fold",
        "Aging"
      ],
      "interventions": [
        {
          "name": "Split-face injection of RHA® 4 with a cannula into a single NLF.",
          "type": "DEVICE"
        },
        {
          "name": "Split-face injection of RHA® 4 with a needle (TSK 27G x ½\") into the contralateral NLF.",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Teoxane SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2021-03-15",
      "completion_date": "2021-11-29",
      "has_results": true,
      "last_update_posted_date": "2023-03-09",
      "last_synced_at": "2026-10-21T03:07:44.555Z",
      "location_count": 4,
      "location_summary": "Encinitas, California • West Palm Beach, Florida • Chapel Hill, North Carolina + 1 more",
      "locations": [
        {
          "city": "Encinitas",
          "state": "California"
        },
        {
          "city": "West Palm Beach",
          "state": "Florida"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04754646"
    }
  ]
}