{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Wrinkles+and+Rhytides&page=2",
    "query": {
      "condition": "Wrinkles and Rhytides",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Wrinkles+and+Rhytides&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T04:28:29.944Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01034956",
      "title": "Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Rhytids",
        "Wrinkles"
      ],
      "interventions": [
        {
          "name": "hyaluronic acid or calcium hydroxylapatite filler",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The New York Eye & Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2009-11",
      "completion_date": "2010-05",
      "has_results": false,
      "last_update_posted_date": "2012-05-01",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01034956"
    },
    {
      "nct_id": "NCT06436261",
      "title": "Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Hybrid-Fractional Laser for Facial Rejuvenation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Photoaging",
        "Wrinkle",
        "Skin Laxity"
      ],
      "interventions": [
        {
          "name": "Hybrid Fractional Laser",
          "type": "PROCEDURE"
        },
        {
          "name": "Facial Cleanser",
          "type": "OTHER"
        },
        {
          "name": "Facial Moisturizer",
          "type": "OTHER"
        },
        {
          "name": "Sunscreen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Revision Skincare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "65 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 65 Years · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2021-12-14",
      "completion_date": "2022-07-01",
      "has_results": false,
      "last_update_posted_date": "2024-05-31",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 2,
      "location_summary": "Atlanta, Georgia • Dallas, Texas",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06436261"
    },
    {
      "nct_id": "NCT00752297",
      "title": "Safety and Efficacy Study of PurTox® Botulinum Toxin Type A to Treat Frown Lines Between the Eyebrows",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Glabellar Rhytides"
      ],
      "interventions": [
        {
          "name": "Preservative-free Saline",
          "type": "DRUG"
        },
        {
          "name": "Mentor Purified Toxin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mentor Worldwide, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 402,
      "start_date": "2007-06",
      "completion_date": "2008-05",
      "has_results": false,
      "last_update_posted_date": "2011-09-12",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 1,
      "location_summary": "Santa Barbara, California",
      "locations": [
        {
          "city": "Santa Barbara",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00752297"
    },
    {
      "nct_id": "NCT05987163",
      "title": "Study to Evaluate the Safety and Effectiveness of GP0116",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Manifestations"
      ],
      "interventions": [
        {
          "name": "GP0116",
          "type": "DEVICE"
        },
        {
          "name": "Active Comparator: FDA approved dermal filler device (RHA 3)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Galderma R&D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 186,
      "start_date": "2023-04-12",
      "completion_date": "2026-03-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-02",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 18,
      "location_summary": "Santa Monica, California • Vista, California • Westport, Connecticut + 14 more",
      "locations": [
        {
          "city": "Santa Monica",
          "state": "California"
        },
        {
          "city": "Vista",
          "state": "California"
        },
        {
          "city": "Westport",
          "state": "Connecticut"
        },
        {
          "city": "Bradenton",
          "state": "Florida"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05987163"
    },
    {
      "nct_id": "NCT00907387",
      "title": "Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lateral Canthal Lines"
      ],
      "interventions": [
        {
          "name": "RT001",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Revance Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "30 Years to 60 Years"
      },
      "enrollment_count": 72,
      "start_date": "2009-04",
      "completion_date": "2009-10",
      "has_results": false,
      "last_update_posted_date": "2014-01-17",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 9,
      "location_summary": "Birmingham, Alabama • San Francisco, California • Coral Gables, Florida + 5 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Chestnut Hill",
          "state": "Massachusetts"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00907387"
    },
    {
      "nct_id": "NCT01212809",
      "title": "Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Intrinsic Aging of Skin"
      ],
      "interventions": [
        {
          "name": "Juvéderm Ultra",
          "type": "DEVICE"
        },
        {
          "name": "Cosmoderm 1",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Steven Fagien",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "25 Years to 70 Years"
      },
      "enrollment_count": 30,
      "start_date": "2010-09",
      "completion_date": "2011-06",
      "has_results": false,
      "last_update_posted_date": "2011-09-12",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 1,
      "location_summary": "Boca Raton, Florida",
      "locations": [
        {
          "city": "Boca Raton",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01212809"
    },
    {
      "nct_id": "NCT01519934",
      "title": "A Retrospective Study to Evaluate the Effectiveness of the Ulthera System",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Skin Laxity",
        "Wrinkles"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Ulthera, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "25 Years to 85 Years"
      },
      "enrollment_count": 48,
      "start_date": "2011-10",
      "completion_date": "2012-08",
      "has_results": true,
      "last_update_posted_date": "2017-12-18",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01519934"
    },
    {
      "nct_id": "NCT04969380",
      "title": "SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Laxity"
      ],
      "interventions": [
        {
          "name": "Sofwave",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sofwave Medical LTD",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "35 Years to 80 Years"
      },
      "enrollment_count": 20,
      "start_date": "2020-02-27",
      "completion_date": "2023-02-27",
      "has_results": false,
      "last_update_posted_date": "2023-11-18",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 1,
      "location_summary": "Irvine, California",
      "locations": [
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04969380"
    },
    {
      "nct_id": "NCT03911102",
      "title": "Efficacy and Safety of Increasing Doses of DaxibotulinumtoxinA for Injection (DAXI for Injection) in the Treatment of Moderate or Severe Lateral Canthal Lines",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Lateral Canthal Lines"
      ],
      "interventions": [
        {
          "name": "DaxibotulinumtoxinA for injection",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Revance Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 63,
      "start_date": "2019-03-11",
      "completion_date": "2020-04-23",
      "has_results": true,
      "last_update_posted_date": "2023-06-27",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 4,
      "location_summary": "Sacramento, California • Sarasota, Florida • Itasca, Illinois + 1 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Sarasota",
          "state": "Florida"
        },
        {
          "city": "Itasca",
          "state": "Illinois"
        },
        {
          "city": "Arlington",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03911102"
    },
    {
      "nct_id": "NCT06192550",
      "title": "Functional Usability and Feasibility Testing of the Profound Matrix™ System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle",
        "Acne Scars - Mixed Atrophic and Hypertrophic"
      ],
      "interventions": [
        {
          "name": "Profound Matrix™ System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Candela Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 193,
      "start_date": "2020-10-28",
      "completion_date": "2023-12-29",
      "has_results": false,
      "last_update_posted_date": "2025-02-13",
      "last_synced_at": "2026-07-24T04:28:29.944Z",
      "location_count": 4,
      "location_summary": "Marlborough, Massachusetts • New York, New York • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Marlborough",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06192550"
    }
  ]
}