{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0%25+N2O",
    "query": {
      "intervention": "0% N2O"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 15,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0%25+N2O&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-05T08:09:49.199Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00000254",
      "title": "Isoflurane at Subanesthetic Concentrations - 6",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "40% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "Sham comparator",
          "type": "OTHER"
        },
        {
          "name": "0.2% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "0.4% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "0.6% isoflurane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "34 Years",
        "sex": "MALE",
        "summary": "21 Years to 34 Years · Male only"
      },
      "enrollment_count": 10,
      "start_date": "1995-01",
      "completion_date": "1995-09",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000254"
    },
    {
      "nct_id": "NCT02383004",
      "title": "Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Delirium",
        "Psychomotor Agitation"
      ],
      "interventions": [
        {
          "name": "Acupuncture",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "6 Years",
        "sex": "ALL",
        "summary": "1 Year to 6 Years"
      },
      "enrollment_count": 100,
      "start_date": "2015-02",
      "completion_date": "2016-11",
      "has_results": false,
      "last_update_posted_date": "2017-01-18",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02383004"
    },
    {
      "nct_id": "NCT00000249",
      "title": "Effects of Subanesthetic Concentrations of Nitrous Oxide - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "ALL",
        "summary": "21 Years to 37 Years"
      },
      "enrollment_count": 10,
      "start_date": "1993-09",
      "completion_date": "1995-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000249"
    },
    {
      "nct_id": "NCT05895383",
      "title": "Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Procedural Pain",
        "Pain Catastrophizing",
        "Procedural Anxiety"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "85 Years",
        "sex": "MALE",
        "summary": "21 Years to 85 Years · Male only"
      },
      "enrollment_count": 35,
      "start_date": "2023-05-24",
      "completion_date": "2027-01-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05895383"
    },
    {
      "nct_id": "NCT02050152",
      "title": "Nitrous Oxide Induction Induces Amnesia in Pediatric Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amnesia"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide 0%",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 33%",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 66%",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "State University of New York at Buffalo",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "6 Years to 12 Years"
      },
      "enrollment_count": 90,
      "start_date": "2013-05",
      "completion_date": "2013-10",
      "has_results": true,
      "last_update_posted_date": "2026-06-30",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02050152"
    },
    {
      "nct_id": "NCT00000257",
      "title": "Effects of Alcohol History on Effects of Nitrous Oxide - 9",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol-Related Disorders",
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "0% N2O and 10% N2O",
          "type": "DRUG"
        },
        {
          "name": "0% N2O and 20% N2O",
          "type": "DRUG"
        },
        {
          "name": "0% N2O and 30% N2O",
          "type": "DRUG"
        },
        {
          "name": "0% N2O and 40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "ALL",
        "summary": "21 Years to 37 Years"
      },
      "enrollment_count": 19,
      "start_date": "1995-09",
      "completion_date": "1997-04",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000257"
    },
    {
      "nct_id": "NCT00000252",
      "title": "Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "0% N2O",
          "type": "DRUG"
        },
        {
          "name": "10% N2O",
          "type": "DRUG"
        },
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "21 Years to 29 Years"
      },
      "enrollment_count": 11,
      "start_date": "1994-06",
      "completion_date": "1996-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000252"
    },
    {
      "nct_id": "NCT01287052",
      "title": "Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Migraine",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospitals and Clinics of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "8 Years to 18 Years"
      },
      "enrollment_count": 30,
      "start_date": "2011-06",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2015-07-30",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01287052"
    },
    {
      "nct_id": "NCT00000256",
      "title": "Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        },
        {
          "name": "60% N2O",
          "type": "DRUG"
        },
        {
          "name": "80% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "34 Years",
        "sex": "ALL",
        "summary": "22 Years to 34 Years"
      },
      "enrollment_count": 11,
      "start_date": "1995-08",
      "completion_date": "1996-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000256"
    },
    {
      "nct_id": "NCT00000263",
      "title": "Effects of Combined Alcohol and Nitrous Oxide Intake - 15",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "30% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.25 g/Kg ethanol",
          "type": "OTHER"
        },
        {
          "name": "0.5 g/KG ethanol",
          "type": "OTHER"
        },
        {
          "name": "0 g/Kg ethanol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 11,
      "start_date": "1997-01",
      "completion_date": "1998-10",
      "has_results": false,
      "last_update_posted_date": "2015-05-27",
      "last_synced_at": "2026-09-05T08:09:49.199Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000263"
    }
  ]
}