{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0.243%25+sodium+fluoride", "query": { "intervention": "0.243% sodium fluoride" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 16, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0.243%25+sodium+fluoride&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-27T11:51:53.827Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02194621", "title": "Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Oral Bacteria Levels in the Mouth" ], "interventions": [ { "name": "Total Flavor option 1", "type": "DRUG" }, { "name": "Total Flavor option 2", "type": "DRUG" }, { "name": "Placebo toothpaste: Crest Cavity Protection toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "22 Years", "maximum_age": "58 Years", "sex": "ALL", "summary": "22 Years to 58 Years" }, "enrollment_count": 128, "start_date": "2014-01", "completion_date": "2014-03", "has_results": true, "last_update_posted_date": "2016-04-15", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Newark, New Jersey", "locations": [ { "city": "Newark", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT02194621" }, { "nct_id": "NCT06143670", "title": "A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "Sodium fluoride toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 159, "start_date": "2023-11-29", "completion_date": "2024-03-12", "has_results": true, "last_update_posted_date": "2025-03-21", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06143670" }, { "nct_id": "NCT04006483", "title": "Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Dental Plaque" ], "interventions": [ { "name": "Stannous fluoride dentifrice", "type": "DRUG" }, { "name": "Positive control dentifrice", "type": "DRUG" }, { "name": "Negative control dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": null, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2359, "start_date": "2018-01-08", "completion_date": "2018-11-30", "has_results": false, "last_update_posted_date": "2023-11-18", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04006483" }, { "nct_id": "NCT04005417", "title": "Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Dentine Hypersensitivity" ], "interventions": [ { "name": "Stannous fluoride dentifrice", "type": "DRUG" }, { "name": "Positive control dentifrice", "type": "DRUG" }, { "name": "Negative control dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1036, "start_date": "2018-01-08", "completion_date": "2018-11-30", "has_results": false, "last_update_posted_date": "2019-07-02", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04005417" }, { "nct_id": "NCT07425509", "title": "Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Oral Malodor (Halitosis)" ], "interventions": [ { "name": "Sodium Fluoride Dentifrice", "type": "DRUG" }, { "name": "Stannous Fluoride Toothpaste (SnF)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Church & Dwight Company, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 49, "start_date": "2024-09-09", "completion_date": "2024-11-04", "has_results": false, "last_update_posted_date": "2026-02-23", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07425509" }, { "nct_id": "NCT03546491", "title": "Evaluate Dental Plaque Benefit of a Preventive Treatment Gel", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dental Plaque" ], "interventions": [ { "name": "Preventive Gel", "type": "DRUG" }, { "name": "Marketed Control", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 32, "start_date": "2018-05-08", "completion_date": "2018-06-22", "has_results": true, "last_update_posted_date": "2019-09-04", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Mason, Ohio", "locations": [ { "city": "Mason", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03546491" }, { "nct_id": "NCT06957249", "title": "Clinical Study to Evaluate the Tooth Whitening Efficacy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Whitening" ], "interventions": [ { "name": "Optic White 5%HP ActivShine Toothpaste", "type": "DRUG" }, { "name": "Crest3DWhite Advanced Radiant Mint Toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 80, "start_date": "2025-04-25", "completion_date": "2025-05-05", "has_results": false, "last_update_posted_date": "2025-09-03", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Melbourne, Florida", "locations": [ { "city": "Melbourne", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06957249" }, { "nct_id": "NCT05524948", "title": "A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Halitosis" ], "interventions": [ { "name": "Experimental Dentifrice", "type": "OTHER" }, { "name": "Reference Dentifrice", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 104, "start_date": "2022-09-26", "completion_date": "2022-10-27", "has_results": true, "last_update_posted_date": "2024-08-26", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT05524948" }, { "nct_id": "NCT06660069", "title": "A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Plaque", "Gingivitis" ], "interventions": [ { "name": "Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste)", "type": "DRUG" }, { "name": "CPC Mouthwash (Parodontax Active Gum Health Mouthwash)", "type": "DRUG" }, { "name": "Regular Fluoride Toothpaste (Crest Cavity Protection)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 199, "start_date": "2024-11-18", "completion_date": "2025-03-11", "has_results": true, "last_update_posted_date": "2026-03-18", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06660069" }, { "nct_id": "NCT07419737", "title": "Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Plaque" ], "interventions": [ { "name": "Stannous Fluoride Toothpaste (SnF)", "type": "DRUG" }, { "name": "Sodium Fluoride Dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Church & Dwight Company, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "69 Years", "sex": "ALL", "summary": "18 Years to 69 Years" }, "enrollment_count": 91, "start_date": "2024-10-16", "completion_date": "2024-12-04", "has_results": false, "last_update_posted_date": "2026-02-19", "last_synced_at": "2026-09-27T11:51:53.827Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07419737" } ] }