{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0.454%25+stannous+fluoride", "query": { "intervention": "0.454% stannous fluoride" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 40, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=0.454%25+stannous+fluoride&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-28T20:00:50.493Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07398846", "title": "Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Plaque" ], "interventions": [ { "name": "0.454%Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe", "type": "DRUG" }, { "name": "0.76% Sodium Monofluorophosphate (Na MFP) toothpaste", "type": "DRUG" }, { "name": "0.022% Sodium Fluoride mouthwash", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 134, "start_date": "2026-01-26", "completion_date": "2026-04-29", "has_results": false, "last_update_posted_date": "2026-05-22", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Melbourne, Florida", "locations": [ { "city": "Melbourne", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07398846" }, { "nct_id": "NCT07738198", "title": "Dentin Hypersensitivity Reduction Efficacy Clinical", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Dental Hypersensitivity" ], "interventions": [ { "name": "0.454% stannous fluoride toothpaste", "type": "DRUG" }, { "name": "5% potassium nitrate", "type": "DRUG" }, { "name": "0.76% sodium monofluorophosphate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Colgate Palmolive", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 116, "start_date": "2018-11-26", "completion_date": "2018-12-08", "has_results": false, "last_update_posted_date": "2026-07-31", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Costa Mesa, California", "locations": [ { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07738198" }, { "nct_id": "NCT02750943", "title": "Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous Fluoride", "type": "DRUG" }, { "name": "Sodium Monofluorophosphate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 253, "start_date": "2015-11-01", "completion_date": "2016-03-04", "has_results": true, "last_update_posted_date": "2017-10-26", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT02750943" }, { "nct_id": "NCT07704905", "title": "A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dental Plaque", "Gingivitis" ], "interventions": [ { "name": "Test Dentifrice", "type": "DRUG" }, { "name": "Reference Dentifrice (Colgate Cavity Protection Dentifrice)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 110, "start_date": "2026-07-13", "completion_date": "2026-10", "has_results": false, "last_update_posted_date": "2026-08-12", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT07704905" }, { "nct_id": "NCT06143670", "title": "A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "Sodium fluoride toothpaste", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 159, "start_date": "2023-11-29", "completion_date": "2024-03-12", "has_results": true, "last_update_posted_date": "2025-03-21", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06143670" }, { "nct_id": "NCT03970759", "title": "Meta-analysis of Stannous Fluoride and the Effects on Gingival Health", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous Fluoride Dentifrice", "type": "DRUG" }, { "name": "Positive control dentifrice", "type": "DRUG" }, { "name": "Negative control dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 2890, "start_date": "2018-01-08", "completion_date": "2018-11-30", "has_results": false, "last_update_posted_date": "2019-06-17", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Cincinnati, Ohio", "locations": [ { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03970759" }, { "nct_id": "NCT03965039", "title": "A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dentin Hypersensitivity" ], "interventions": [ { "name": "Dipotassium oxalate toothpaste", "type": "DEVICE" }, { "name": "Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "Potassium nitrate toothpaste", "type": "DRUG" }, { "name": "Sodium monofluorophosphate toothpaste", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 120, "start_date": "2019-07-08", "completion_date": "2019-10-03", "has_results": true, "last_update_posted_date": "2020-10-30", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT03965039" }, { "nct_id": "NCT06659471", "title": "Brief Title: a Clinical Study to Assess Gingivitis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Gingival Diseases" ], "interventions": [ { "name": "0.76% Sodium Monofluorophosphate Dentifrice", "type": "DRUG" }, { "name": "0.454% Stannous Fluoride Dentifrice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Procter and Gamble", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 120, "start_date": "2022-03-07", "completion_date": "2022-06-06", "has_results": false, "last_update_posted_date": "2024-10-26", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT06659471" }, { "nct_id": "NCT04123665", "title": "A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Gingivitis" ], "interventions": [ { "name": "Stannous fluoride", "type": "DRUG" }, { "name": "Sodium monofluorophosphate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 98, "start_date": "2013-05-28", "completion_date": "2013-12-11", "has_results": true, "last_update_posted_date": "2020-01-31", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Fort Wayne, Indiana", "locations": [ { "city": "Fort Wayne", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT04123665" }, { "nct_id": "NCT06354270", "title": "A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dentin Sensitivity" ], "interventions": [ { "name": "Stannous fluoride toothpaste", "type": "DRUG" }, { "name": "Regular fluoride toothpaste (Crest Cavity Protection)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HALEON", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 115, "start_date": "2024-04-11", "completion_date": "2024-06-23", "has_results": true, "last_update_posted_date": "2025-06-25", "last_synced_at": "2026-09-28T20:00:50.493Z", "location_count": 1, "location_summary": "Melbourne, Florida", "locations": [ { "city": "Melbourne", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06354270" } ] }