{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=15+%25+Nitrous+oxide",
    "query": {
      "intervention": "15 % Nitrous oxide"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-16T22:30:23.485Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01691690",
      "title": "Analgesic Effect of IV Acetaminophen in Tonsillectomies",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Adenotonsillitis",
        "Tonsillitis"
      ],
      "interventions": [
        {
          "name": "Acetaminophen (paracetamol)",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline Flush",
          "type": "DRUG"
        },
        {
          "name": "Midazolam",
          "type": "DRUG"
        },
        {
          "name": "Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "Nitrous Oxide/Oxygen",
          "type": "DRUG"
        },
        {
          "name": "Propofol",
          "type": "DRUG"
        },
        {
          "name": "Morphine",
          "type": "DRUG"
        },
        {
          "name": "Ondansetron",
          "type": "DRUG"
        },
        {
          "name": "Dexamethasone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Nationwide Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "9 Years",
        "sex": "ALL",
        "summary": "2 Years to 9 Years"
      },
      "enrollment_count": 250,
      "start_date": "2012-10",
      "completion_date": "2016-07",
      "has_results": true,
      "last_update_posted_date": "2017-04-06",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01691690"
    },
    {
      "nct_id": "NCT01287052",
      "title": "Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Migraine",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Children's Hospitals and Clinics of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "8 Years to 18 Years"
      },
      "enrollment_count": 30,
      "start_date": "2011-06",
      "completion_date": "2015-01",
      "has_results": false,
      "last_update_posted_date": "2015-07-30",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01287052"
    },
    {
      "nct_id": "NCT02331108",
      "title": "A Comparison of Inhalation vs. Intravenous Induction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypothermia"
      ],
      "interventions": [
        {
          "name": "Selection of anesthetic induction technique",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 331,
      "start_date": "2014-08",
      "completion_date": "2016-04",
      "has_results": true,
      "last_update_posted_date": "2017-04-17",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02331108"
    },
    {
      "nct_id": "NCT06867068",
      "title": "Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Anesthesia",
        "Tooth Extraction"
      ],
      "interventions": [
        {
          "name": "Midazolam Hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Fentanyl",
          "type": "DRUG"
        },
        {
          "name": "Ketamine",
          "type": "DRUG"
        },
        {
          "name": "Propofol injection",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Albert Einstein College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 73,
      "start_date": "2016-10-04",
      "completion_date": "2024-06-10",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06867068"
    },
    {
      "nct_id": "NCT03360123",
      "title": "Comparison of Triazolam and Midazolam for Anxiolysis During Dental Treatment in the Pediatric Patient",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Anxiety"
      ],
      "interventions": [
        {
          "name": "Midazolam Hydrochloride 2Mg/mL Syrup",
          "type": "DRUG"
        },
        {
          "name": "Triazolam 0.125 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 4,
      "start_date": "2018-01-26",
      "completion_date": "2018-04-11",
      "has_results": false,
      "last_update_posted_date": "2018-06-19",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03360123"
    },
    {
      "nct_id": "NCT00967694",
      "title": "Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Glaucoma",
        "Sedation"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 20,
      "start_date": "2009-08",
      "completion_date": "2011-10",
      "has_results": true,
      "last_update_posted_date": "2014-09-23",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00967694"
    },
    {
      "nct_id": "NCT00000263",
      "title": "Effects of Combined Alcohol and Nitrous Oxide Intake - 15",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "30% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.25 g/Kg ethanol",
          "type": "OTHER"
        },
        {
          "name": "0.5 g/KG ethanol",
          "type": "OTHER"
        },
        {
          "name": "0 g/Kg ethanol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 11,
      "start_date": "1997-01",
      "completion_date": "1998-10",
      "has_results": false,
      "last_update_posted_date": "2015-05-27",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000263"
    },
    {
      "nct_id": "NCT03215121",
      "title": "Mask Study: One-handed vs. Two Handed Technique in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obstructive Sleep Apnea"
      ],
      "interventions": [
        {
          "name": "One handed mask airway, switch to two hands",
          "type": "PROCEDURE"
        },
        {
          "name": "Two handed mask airway + jaw thrust",
          "type": "PROCEDURE"
        },
        {
          "name": "Two handed mask airway, switch to one hand",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Nemours Children's Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "8 Years",
        "sex": "ALL",
        "summary": "1 Year to 8 Years"
      },
      "enrollment_count": 60,
      "start_date": "2018-04-01",
      "completion_date": "2020-01-22",
      "has_results": false,
      "last_update_posted_date": "2020-01-23",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Wilmington, Delaware",
      "locations": [
        {
          "city": "Wilmington",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03215121"
    },
    {
      "nct_id": "NCT00000259",
      "title": "Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "15 % Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.3 % Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "30% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.6% Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "21 Years to 39 Years"
      },
      "enrollment_count": 12,
      "start_date": "1996-08",
      "completion_date": "1997-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000259"
    },
    {
      "nct_id": "NCT07387315",
      "title": "A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Overactive Bladder",
        "Neurogenic Bladder",
        "Urge Incontinence",
        "Pain",
        "Urinary Incontinence",
        "Urinary Bladder, Overactive",
        "Urinary Bladder, Neurogenic",
        "Urinary Bladder Neurogenesis",
        "Urinary Incontinence, Urge",
        "Pelvic Floor Disorders"
      ],
      "interventions": [
        {
          "name": "Pro-Nox Nitrous Oxide/Oxygen Delivery System",
          "type": "DRUG"
        },
        {
          "name": "Standard Care for Bladder Botox Injection",
          "type": "DRUG"
        },
        {
          "name": "Sham Mask",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "TriHealth Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 96,
      "start_date": "2026-02",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-02-04",
      "last_synced_at": "2026-09-16T22:30:23.485Z",
      "location_count": 2,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07387315"
    }
  ]
}