{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=21+mg+transdermal+nicotine&page=2",
    "query": {
      "intervention": "21 mg transdermal nicotine",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 39,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=21+mg+transdermal+nicotine&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=21+mg+transdermal+nicotine&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-06T05:06:04.642Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01456936",
      "title": "Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "varenicline tartrate",
          "type": "DRUG"
        },
        {
          "name": "bupropion hydrochloride",
          "type": "DRUG"
        },
        {
          "name": "Nicotine Replacement Therapy Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 8144,
      "start_date": "2011-11",
      "completion_date": "2015-01",
      "has_results": true,
      "last_update_posted_date": "2016-06-10",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 77,
      "location_summary": "Mobile, Alabama • Phoenix, Arizona • Encino, California + 61 more",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Encino",
          "state": "California"
        },
        {
          "city": "Escondido",
          "state": "California"
        },
        {
          "city": "Imperial",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01456936"
    },
    {
      "nct_id": "NCT01807871",
      "title": "Treatment of Smoking Lapses and Relapses",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "nicotine patch, experimental use",
          "type": "DRUG"
        },
        {
          "name": "nicotine patch, labeled use",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 701,
      "start_date": "2013-03",
      "completion_date": "2016-02",
      "has_results": true,
      "last_update_posted_date": "2017-10-13",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01807871"
    },
    {
      "nct_id": "NCT01213524",
      "title": "Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder",
        "Schizophrenia"
      ],
      "interventions": [
        {
          "name": "sensorimotor replacement",
          "type": "BEHAVIORAL"
        },
        {
          "name": "42 mg transdermal nicotine replacement",
          "type": "DRUG"
        },
        {
          "name": "Placebo transdermal nicotine",
          "type": "DRUG"
        },
        {
          "name": "usual brand smoking",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 75,
      "start_date": "2005-09",
      "completion_date": "2011-03",
      "has_results": true,
      "last_update_posted_date": "2020-10-19",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01213524"
    },
    {
      "nct_id": "NCT01372254",
      "title": "Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Cigarette Smoking",
        "Drug Use"
      ],
      "interventions": [
        {
          "name": "Standard Treatment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "BAD-AS",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Maryland, College Park",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 96,
      "start_date": "2011-12",
      "completion_date": "2015-05",
      "has_results": true,
      "last_update_posted_date": "2022-05-18",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01372254"
    },
    {
      "nct_id": "NCT00218218",
      "title": "Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Schizophrenia and Disorders With Psychotic Features",
        "Tobacco Use Disorder",
        "Schizophrenia"
      ],
      "interventions": [
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "21 mg transdermal nicotine",
          "type": "DRUG"
        },
        {
          "name": "placebo patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute on Drug Abuse (NIDA)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 48,
      "start_date": "2002-06",
      "completion_date": "2005-02",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00218218"
    },
    {
      "nct_id": "NCT02511236",
      "title": "Addressing Racial/Ethnic Tobacco Health Disparities Via Group Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Group Cognitive Behavioral Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "General Health Education",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 356,
      "start_date": "2015-08",
      "completion_date": "2019-10-23",
      "has_results": true,
      "last_update_posted_date": "2021-06-24",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 2,
      "location_summary": "Coral Gables, Florida • Tampa, Florida",
      "locations": [
        {
          "city": "Coral Gables",
          "state": "Florida"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02511236"
    },
    {
      "nct_id": "NCT00960778",
      "title": "Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol)",
          "type": "DRUG"
        },
        {
          "name": "denicotinized cigarettes (Quest 3 cigarettes)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "21 Years to 60 Years"
      },
      "enrollment_count": 33,
      "start_date": "2009-03",
      "completion_date": "2012-06",
      "has_results": true,
      "last_update_posted_date": "2018-10-23",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00960778"
    },
    {
      "nct_id": "NCT00390559",
      "title": "Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Drug Addiction",
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Nicotine transdermal system",
          "type": "DRUG"
        },
        {
          "name": "Nicotine containing cigarette",
          "type": "OTHER"
        },
        {
          "name": "Placebo cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 80,
      "start_date": "2005-10",
      "completion_date": "2008-03",
      "has_results": true,
      "last_update_posted_date": "2012-07-18",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00390559"
    },
    {
      "nct_id": "NCT07089901",
      "title": "Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking"
      ],
      "interventions": [
        {
          "name": "transdermal nicotine replacement therapy",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 600,
      "start_date": "2026-05-06",
      "completion_date": "2030-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-23",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07089901"
    },
    {
      "nct_id": "NCT00736255",
      "title": "Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Transdermal Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "Lis-dexamphetamine (Vyvanse)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 32,
      "start_date": "2007-12",
      "completion_date": "2011-07",
      "has_results": true,
      "last_update_posted_date": "2018-11-30",
      "last_synced_at": "2026-10-06T05:06:04.642Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00736255"
    }
  ]
}