{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=30%25+Nitrous+oxide&page=2",
    "query": {
      "intervention": "30% Nitrous oxide",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 30,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=30%25+Nitrous+oxide&page=3&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=30%25+Nitrous+oxide&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-05T19:03:39.456Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00000259",
      "title": "Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "15 % Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.3 % Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "30% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "0.6% Sevoflurane",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "21 Years to 39 Years"
      },
      "enrollment_count": 12,
      "start_date": "1996-08",
      "completion_date": "1997-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000259"
    },
    {
      "nct_id": "NCT02755090",
      "title": "Nitrous Oxide Versus Intravenous Sedation for Anesthesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy Termination in Second Trimester"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        },
        {
          "name": "IV Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 39,
      "start_date": "2016-07",
      "completion_date": "2017-05",
      "has_results": true,
      "last_update_posted_date": "2017-09-15",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 2,
      "location_summary": "Denver, Colorado • Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02755090"
    },
    {
      "nct_id": "NCT00000249",
      "title": "Effects of Subanesthetic Concentrations of Nitrous Oxide - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "ALL",
        "summary": "21 Years to 37 Years"
      },
      "enrollment_count": 10,
      "start_date": "1993-09",
      "completion_date": "1995-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000249"
    },
    {
      "nct_id": "NCT04401527",
      "title": "Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID-19",
        "Acute Respiratory Distress Syndrome",
        "Acute Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Sodium Nitrite",
          "type": "DRUG"
        },
        {
          "name": "Normal Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hope Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-07-22",
      "completion_date": "2020-08-15",
      "has_results": false,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 2,
      "location_summary": "Tampa, Florida • Fort Worth, Texas",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Fort Worth",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04401527"
    },
    {
      "nct_id": "NCT00000251",
      "title": "Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "0.2% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "0.4% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "100% oxygen",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "32 Years",
        "sex": "ALL",
        "summary": "21 Years to 32 Years"
      },
      "enrollment_count": 10,
      "start_date": "1994-04",
      "completion_date": "1996-01",
      "has_results": false,
      "last_update_posted_date": "2015-12-02",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000251"
    },
    {
      "nct_id": "NCT00924118",
      "title": "Sodium Nitrite in Acute Myocardial Infarction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Myocardial Infarction"
      ],
      "interventions": [
        {
          "name": "Sodium Nitrite",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "21 Years to 75 Years"
      },
      "enrollment_count": 30,
      "start_date": "2009-07",
      "completion_date": "2016-06",
      "has_results": true,
      "last_update_posted_date": "2018-05-14",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 3,
      "location_summary": "Baltimore, Maryland • Worcester, Massachusetts",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Worcester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00924118"
    },
    {
      "nct_id": "NCT03513757",
      "title": "Dexmedetomidine and Propofol for Pediatric MRI Sedation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Headache",
        "Tumor",
        "Seizure Disorder",
        "Neurofibromatoses",
        "Hydrocephalus",
        "Abdominal Neoplasm",
        "Spine Deformity"
      ],
      "interventions": [
        {
          "name": "propofol",
          "type": "DRUG"
        },
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Glycopyrrolate",
          "type": "DRUG"
        },
        {
          "name": "Lidocaine 1% Injectable Solution",
          "type": "DRUG"
        },
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        },
        {
          "name": "Sevoflurane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Months",
        "maximum_age": "60 Months",
        "sex": "ALL",
        "summary": "12 Months to 60 Months"
      },
      "enrollment_count": 40,
      "start_date": "2018-03-04",
      "completion_date": "2018-10-21",
      "has_results": true,
      "last_update_posted_date": "2020-02-21",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03513757"
    },
    {
      "nct_id": "NCT04749043",
      "title": "Virtual Reality Compared to Nitrous Oxide for Labor Analgesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Labor Pain"
      ],
      "interventions": [
        {
          "name": "Oculus Quest 2 Virtual Reality Device",
          "type": "DEVICE"
        },
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Brendan Carvalho",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2021-02-18",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-03-18",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Stanford, California",
      "locations": [
        {
          "city": "Stanford",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04749043"
    },
    {
      "nct_id": "NCT00000258",
      "title": "Role of Instructions in Nitrous Oxide Effects and Choice - 10",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide 10% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 20% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 30% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 40% and placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "32 Years",
        "sex": "ALL",
        "summary": "21 Years to 32 Years"
      },
      "enrollment_count": 22,
      "start_date": "1996-04",
      "completion_date": "1997-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000258"
    },
    {
      "nct_id": "NCT03360123",
      "title": "Comparison of Triazolam and Midazolam for Anxiolysis During Dental Treatment in the Pediatric Patient",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Anxiety"
      ],
      "interventions": [
        {
          "name": "Midazolam Hydrochloride 2Mg/mL Syrup",
          "type": "DRUG"
        },
        {
          "name": "Triazolam 0.125 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 4,
      "start_date": "2018-01-26",
      "completion_date": "2018-04-11",
      "has_results": false,
      "last_update_posted_date": "2018-06-19",
      "last_synced_at": "2026-10-05T19:03:39.456Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03360123"
    }
  ]
}