{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=40%25+N2O",
    "query": {
      "intervention": "40% N2O"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 15,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=40%25+N2O&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T10:39:50.572Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00000256",
      "title": "Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        },
        {
          "name": "60% N2O",
          "type": "DRUG"
        },
        {
          "name": "80% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "34 Years",
        "sex": "ALL",
        "summary": "22 Years to 34 Years"
      },
      "enrollment_count": 11,
      "start_date": "1995-08",
      "completion_date": "1996-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000256"
    },
    {
      "nct_id": "NCT00000255",
      "title": "Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "ALL",
        "summary": "21 Years to 37 Years"
      },
      "enrollment_count": 10,
      "start_date": "1995-04",
      "completion_date": "1996-05",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000255"
    },
    {
      "nct_id": "NCT00990769",
      "title": "The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Emergence Agitation"
      ],
      "interventions": [
        {
          "name": "Depth of anesthesia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "8 Years",
        "sex": "ALL",
        "summary": "2 Years to 8 Years"
      },
      "enrollment_count": 40,
      "start_date": "2009-09",
      "completion_date": "2010-09",
      "has_results": true,
      "last_update_posted_date": "2013-05-31",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00990769"
    },
    {
      "nct_id": "NCT00000252",
      "title": "Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "0% N2O",
          "type": "DRUG"
        },
        {
          "name": "10% N2O",
          "type": "DRUG"
        },
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "29 Years",
        "sex": "ALL",
        "summary": "21 Years to 29 Years"
      },
      "enrollment_count": 11,
      "start_date": "1994-06",
      "completion_date": "1996-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000252"
    },
    {
      "nct_id": "NCT00000249",
      "title": "Effects of Subanesthetic Concentrations of Nitrous Oxide - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "20% N2O",
          "type": "DRUG"
        },
        {
          "name": "30% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "37 Years",
        "sex": "ALL",
        "summary": "21 Years to 37 Years"
      },
      "enrollment_count": 10,
      "start_date": "1993-09",
      "completion_date": "1995-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000249"
    },
    {
      "nct_id": "NCT00000250",
      "title": "Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "0% N2O",
          "type": "DRUG"
        },
        {
          "name": "40% N2O",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "32 Years",
        "sex": "ALL",
        "summary": "21 Years to 32 Years"
      },
      "enrollment_count": 12,
      "start_date": "1993-12",
      "completion_date": "1995-05",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000250"
    },
    {
      "nct_id": "NCT00000254",
      "title": "Isoflurane at Subanesthetic Concentrations - 6",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "40% Nitrous oxide",
          "type": "DRUG"
        },
        {
          "name": "Sham comparator",
          "type": "OTHER"
        },
        {
          "name": "0.2% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "0.4% isoflurane",
          "type": "DRUG"
        },
        {
          "name": "0.6% isoflurane",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "34 Years",
        "sex": "MALE",
        "summary": "21 Years to 34 Years · Male only"
      },
      "enrollment_count": 10,
      "start_date": "1995-01",
      "completion_date": "1995-09",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000254"
    },
    {
      "nct_id": "NCT00000258",
      "title": "Role of Instructions in Nitrous Oxide Effects and Choice - 10",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide 10% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 20% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 30% & placebo",
          "type": "DRUG"
        },
        {
          "name": "Nitrous oxide 40% and placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "32 Years",
        "sex": "ALL",
        "summary": "21 Years to 32 Years"
      },
      "enrollment_count": 22,
      "start_date": "1996-04",
      "completion_date": "1997-11",
      "has_results": false,
      "last_update_posted_date": "2015-05-28",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00000258"
    },
    {
      "nct_id": "NCT03435055",
      "title": "Network-Level Effects of Nitrous Oxide in the Human Brain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide Gas for Inhalation",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "21 Years to 40 Years"
      },
      "enrollment_count": 21,
      "start_date": "2017-07-21",
      "completion_date": "2019-10-11",
      "has_results": true,
      "last_update_posted_date": "2021-11-30",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03435055"
    },
    {
      "nct_id": "NCT02096575",
      "title": "Nitrous Oxide for Pain Management of First Trimester Surgical Abortion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Abortion in First Trimester"
      ],
      "interventions": [
        {
          "name": "Nitrous oxide administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of New Mexico",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 140,
      "start_date": "2012-08",
      "completion_date": "2015-04",
      "has_results": true,
      "last_update_posted_date": "2016-04-19",
      "last_synced_at": "2026-09-04T10:39:50.572Z",
      "location_count": 1,
      "location_summary": "Albuquerque, New Mexico",
      "locations": [
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02096575"
    }
  ]
}