{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=5%25+KNO3+toothpaste",
    "query": {
      "intervention": "5% KNO3 toothpaste"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-16T14:26:55.057Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06242444",
      "title": "An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tooth Erosion"
      ],
      "interventions": [
        {
          "name": "Experimental Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Placebo Control Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 33,
      "start_date": "2024-02-26",
      "completion_date": "2024-05-07",
      "has_results": true,
      "last_update_posted_date": "2025-05-08",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06242444"
    },
    {
      "nct_id": "NCT01657903",
      "title": "Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Erosion",
        "Acid Wear"
      ],
      "interventions": [
        {
          "name": "Sodium Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Potassium nitrate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 56,
      "start_date": "2011-11",
      "completion_date": "2012-02",
      "has_results": true,
      "last_update_posted_date": "2015-01-26",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01657903"
    },
    {
      "nct_id": "NCT07761715",
      "title": "The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Teeth Staining"
      ],
      "interventions": [
        {
          "name": "Toothpaste",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boka LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-05-11",
      "completion_date": "2026-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-13",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07761715"
    },
    {
      "nct_id": "NCT03267511",
      "title": "A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "5% KNO3 / 0.2542% NaF dentifrice with 0.5% spherical silica",
          "type": "DRUG"
        },
        {
          "name": "5% KNO3 / 0.2542% NaF dentifrice with 1% spherical silica and 5% STP",
          "type": "DRUG"
        },
        {
          "name": "5% KNO3 / 0.2542% NaF dentifrice with 6% abrasive silica",
          "type": "DRUG"
        },
        {
          "name": "5% KNO3 / 0.2543% NaF dentifrice with 16% abrasive silica and 5% STP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 123,
      "start_date": "2017-09-25",
      "completion_date": "2017-12-02",
      "has_results": true,
      "last_update_posted_date": "2019-01-08",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Fort Wayne, Indiana",
      "locations": [
        {
          "city": "Fort Wayne",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03267511"
    },
    {
      "nct_id": "NCT06949072",
      "title": "A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Test Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Negative Control Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 47,
      "start_date": "2025-04-28",
      "completion_date": "2025-09-11",
      "has_results": false,
      "last_update_posted_date": "2025-09-24",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06949072"
    },
    {
      "nct_id": "NCT04590040",
      "title": "Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dentin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "OTHER"
        },
        {
          "name": "15% nano-HAP toothpaste",
          "type": "DEVICE"
        },
        {
          "name": "5% KNO3 toothpaste",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "20 Years to 80 Years"
      },
      "enrollment_count": 192,
      "start_date": "2020-07-28",
      "completion_date": "2023-03-01",
      "has_results": true,
      "last_update_posted_date": "2023-08-16",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04590040"
    },
    {
      "nct_id": "NCT02918617",
      "title": "Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dentin Sensitivity"
      ],
      "interventions": [
        {
          "name": "Control toothpaste containing Novamin® technology",
          "type": "DRUG"
        },
        {
          "name": "Control toothpaste containing 1500 ppm fluoride as MFP",
          "type": "DRUG"
        },
        {
          "name": "Test toothpaste with nano-HAP (high concentration)",
          "type": "DRUG"
        },
        {
          "name": "Test toothpaste with nano-HAP (low concentration)",
          "type": "DRUG"
        },
        {
          "name": "Test toothpaste with nano-HAP and (Potassium Nitrate) KNO3",
          "type": "DRUG"
        },
        {
          "name": "Control toothpaste without nano-HAP",
          "type": "DRUG"
        },
        {
          "name": "Test toothpaste with nano-HAP (medium concentration)",
          "type": "DRUG"
        },
        {
          "name": "Test cream with nano-HAP (higher concentration)",
          "type": "DRUG"
        },
        {
          "name": "Control cream without nano-HAP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 203,
      "start_date": "2015-05",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2018-11-16",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02918617"
    },
    {
      "nct_id": "NCT05459558",
      "title": "Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "Experimental Dentifrice 1",
          "type": "DRUG"
        },
        {
          "name": "Experimental Dentifrice 2",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 280,
      "start_date": "2022-09-15",
      "completion_date": "2022-12-04",
      "has_results": true,
      "last_update_posted_date": "2024-04-12",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05459558"
    },
    {
      "nct_id": "NCT03296072",
      "title": "In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Tooth Erosion"
      ],
      "interventions": [
        {
          "name": "0.254% w/w sodium fluoride and 5% KNO3",
          "type": "DRUG"
        },
        {
          "name": "0.454% w/w stannous fluoride",
          "type": "DRUG"
        },
        {
          "name": "5% KNO3",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 62,
      "start_date": "2017-11-13",
      "completion_date": "2018-01-16",
      "has_results": true,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03296072"
    },
    {
      "nct_id": "NCT06150573",
      "title": "A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dentin Sensitivity",
        "Oral Hygiene"
      ],
      "interventions": [
        {
          "name": "Test Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Reference Dentifrice (Aquafresh Cavity Protection)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "HALEON",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 160,
      "start_date": "2023-11-27",
      "completion_date": "2024-07-18",
      "has_results": true,
      "last_update_posted_date": "2025-07-24",
      "last_synced_at": "2026-09-16T14:26:55.057Z",
      "location_count": 1,
      "location_summary": "Las Vegas, Nevada",
      "locations": [
        {
          "city": "Las Vegas",
          "state": "Nevada"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06150573"
    }
  ]
}