{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=5HT3+receptor+antagonist", "query": { "intervention": "5HT3 receptor antagonist" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 28, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=5HT3+receptor+antagonist&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-14T15:54:30.514Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03239210", "title": "Effects of Ondansetron in Obsessive-compulsive and Tic Disorders", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obsessive-Compulsive Disorder", "Tic Disorders", "Tourette Syndrome" ], "interventions": [ { "name": "Ondansetron", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "NYU Langone Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 110, "start_date": "2017-06-16", "completion_date": "2022-05-16", "has_results": true, "last_update_posted_date": "2024-05-03", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 2, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03239210" }, { "nct_id": "NCT06863272", "title": "A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Castration-Resistant Prostatic Cancer", "Metastasis" ], "interventions": [ { "name": "Docetaxel", "type": "DRUG" }, { "name": "Ifinatamab Deruxtecan", "type": "DRUG" }, { "name": "Opevesostat", "type": "DRUG" }, { "name": "Abiraterone", "type": "DRUG" }, { "name": "Enzalutamide", "type": "DRUG" }, { "name": "Rescue Medication", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 360, "start_date": "2025-07-03", "completion_date": "2031-04-01", "has_results": false, "last_update_posted_date": "2026-09-11", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 9, "location_summary": "Los Angeles, California • Orange, California • San Francisco, California + 6 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT06863272" }, { "nct_id": "NCT06780085", "title": "A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Carcinoma, Non-Small-Cell Lung" ], "interventions": [ { "name": "Raludotatug Deruxtecan", "type": "BIOLOGICAL" }, { "name": "Ifinatamab Deruxtecan", "type": "BIOLOGICAL" }, { "name": "Docetetaxel", "type": "DRUG" }, { "name": "5-hydroxytryptamine subtype 3 receptor antagonist", "type": "DRUG" }, { "name": "Neurokinin-1 receptor antagonist", "type": "DRUG" }, { "name": "Corticosteroid", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 96, "start_date": "2025-05-13", "completion_date": "2032-03-12", "has_results": false, "last_update_posted_date": "2026-08-25", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 3, "location_summary": "Lexington, Kentucky • Baltimore, Maryland • Pittsburgh, Pennsylvania", "locations": [ { "city": "Lexington", "state": "Kentucky" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06780085" }, { "nct_id": "NCT02407600", "title": "Study Assessing Fosaprepitant in Advanced NSCLC Patients Treated With Carboplatin Based Chemotherapy", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Non-small Cell Lung Cancer", "Vomiting", "Nausea", "Emesis" ], "interventions": [ { "name": "FOSAPREPITANT (Emend)", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ajeet Gajra", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 150, "start_date": "2015-04", "completion_date": "2018-02", "has_results": false, "last_update_posted_date": "2015-04-03", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 1, "location_summary": "Syracuse, New York", "locations": [ { "city": "Syracuse", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02407600" }, { "nct_id": "NCT00880191", "title": "Gabapentin in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Nausea and Vomiting", "Unspecified Adult Solid Tumor, Protocol Specific" ], "interventions": [ { "name": "dexamethasone", "type": "DRUG" }, { "name": "gabapentin", "type": "DRUG" }, { "name": "placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Alliance for Clinical Trials in Oncology", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 430, "start_date": "2009-04", "completion_date": "2015-05", "has_results": true, "last_update_posted_date": "2016-07-06", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 247, "location_summary": "Scottsdale, Arizona • Aurora, Colorado • Boulder, Colorado + 163 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Boulder", "state": "Colorado" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT00880191" }, { "nct_id": "NCT00326248", "title": "Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Nausea and Vomiting, Postoperative" ], "interventions": [ { "name": "GW679769 (casopitant)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 482, "start_date": "2006-03", "completion_date": "2006-07", "has_results": false, "last_update_posted_date": "2016-10-26", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 26, "location_summary": "Montgomery, Alabama • Sheffield, Alabama • Phoenix, Arizona + 20 more", "locations": [ { "city": "Montgomery", "state": "Alabama" }, { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Boynton Beach", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00326248" }, { "nct_id": "NCT00655850", "title": "Lower Dose Chemotherapy Given More Frequent With Avastin to Treat Advanced Non-Squamous Non-Small Cell Lung Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Non-Small Cell Lung Cancer" ], "interventions": [ { "name": "Paclitaxel", "type": "DRUG" }, { "name": "Gemcitabine", "type": "DRUG" }, { "name": "Avastin", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "University of Alabama at Birmingham", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 39, "start_date": "2008-03", "completion_date": "2016-09", "has_results": true, "last_update_posted_date": "2017-07-17", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 1, "location_summary": "Birmingham, Alabama", "locations": [ { "city": "Birmingham", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT00655850" }, { "nct_id": "NCT07169851", "title": "A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Nausea", "Vomiting", "Drug-Related Side Effects and Adverse Reactions", "Neoplasms" ], "interventions": [ { "name": "LY3537021", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Standard of Care Antiemetic Therapies", "type": "DRUG" }, { "name": "Background Chemotherapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 204, "start_date": "2025-11-28", "completion_date": "2027-02", "has_results": false, "last_update_posted_date": "2026-09-04", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 21, "location_summary": "Greenbrae, California • Irvine, California • Los Alamitos, California + 18 more", "locations": [ { "city": "Greenbrae", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Los Alamitos", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Fort Collins", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT07169851" }, { "nct_id": "NCT02447835", "title": "Effect of Short Term Atypical Antipsychotic Administration Compared to Placebo on Hepatic Insulin Extraction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Normal Non-fluency" ], "interventions": [ { "name": "Olanzapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Michael Rickels", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "18 Years to 40 Years" }, "enrollment_count": 15, "start_date": "2012-08", "completion_date": "2014-12", "has_results": false, "last_update_posted_date": "2015-05-19", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02447835" }, { "nct_id": "NCT06925737", "title": "A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Prostate Cancer", "Prostatic Neoplasms" ], "interventions": [ { "name": "Ifinatamab deruxtecan", "type": "DRUG" }, { "name": "Docetaxel", "type": "DRUG" }, { "name": "Prednisone", "type": "DRUG" }, { "name": "Rescue Medication", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 1440, "start_date": "2025-05-13", "completion_date": "2031-01-06", "has_results": false, "last_update_posted_date": "2026-09-11", "last_synced_at": "2026-09-14T15:54:30.514Z", "location_count": 52, "location_summary": "Phoenix, Arizona • Duarte, California • Irvine, California + 40 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Duarte", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06925737" } ] }