{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=72+hours+hypothermia",
    "query": {
      "intervention": "72 hours hypothermia"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 17,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=72+hours+hypothermia&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-20T19:37:54.481Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03409770",
      "title": "Optimising the Duration of Cooling in Mild Encephalopathy",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Encephalopathy",
        "Hypothermia Neonatal",
        "Magnetic Resonance Spectroscopy"
      ],
      "interventions": [
        {
          "name": "Therapeutic hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thayyil, Sudhin",
      "sponsor_class": "INDIV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 140,
      "start_date": "2019-10-10",
      "completion_date": "2024-08-30",
      "has_results": false,
      "last_update_posted_date": "2023-08-04",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Michigan Center, Michigan",
      "locations": [
        {
          "city": "Michigan Center",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03409770"
    },
    {
      "nct_id": "NCT04426344",
      "title": "Core Warming of COVID-19 Patients",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COVID 19"
      ],
      "interventions": [
        {
          "name": "ensoETM device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2020-10",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2020-10-19",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04426344"
    },
    {
      "nct_id": "NCT01765218",
      "title": "Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Hypoxic Ischemic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Topiramate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Kristin R Hoffman",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 34,
      "start_date": "2013-02",
      "completion_date": "2022-01-27",
      "has_results": true,
      "last_update_posted_date": "2024-06-11",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01765218"
    },
    {
      "nct_id": "NCT01624311",
      "title": "Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Urea Cycle Disorders",
        "Organic Acidemias"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Uta Lichter-Konecki",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "30 Days",
        "sex": "ALL",
        "summary": "1 Day to 30 Days"
      },
      "enrollment_count": 5,
      "start_date": "2007-08",
      "completion_date": "2015-05",
      "has_results": false,
      "last_update_posted_date": "2015-06-01",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 3,
      "location_summary": "Washington D.C., District of Columbia • New York, New York • Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01624311"
    },
    {
      "nct_id": "NCT01793129",
      "title": "Preemie Hypothermia for Neonatal Encephalopathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant, Newborn",
        "Hypoxia, Brain",
        "Hypoxia-Ischemia, Brain",
        "Encephalopathy, Hypoxic-Ischemic",
        "Hypoxic-Ischemic Encephalopathy",
        "Ischemic-Hypoxic Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Hypothermia",
          "type": "DEVICE"
        },
        {
          "name": "Normothermic Control",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "33 Weeks",
        "maximum_age": "35 Weeks",
        "sex": "ALL",
        "summary": "33 Weeks to 35 Weeks"
      },
      "enrollment_count": 168,
      "start_date": "2015-05",
      "completion_date": "2022-12-09",
      "has_results": true,
      "last_update_posted_date": "2024-11-04",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 18,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 14 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01793129"
    },
    {
      "nct_id": "NCT00797680",
      "title": "Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cardiac Arrest",
        "Brain Injury"
      ],
      "interventions": [
        {
          "name": "72 hours hypothermia",
          "type": "OTHER"
        },
        {
          "name": "24 hours hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Week",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "1 Week to 17 Years"
      },
      "enrollment_count": 34,
      "start_date": "2008-10",
      "completion_date": "2015-04",
      "has_results": false,
      "last_update_posted_date": "2016-01-18",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00797680"
    },
    {
      "nct_id": "NCT04176471",
      "title": "TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoxic-Ischemic Encephalopathy Mild",
        "Neonatal Encephalopathy"
      ],
      "interventions": [
        {
          "name": "Therapeutic Hypothermia",
          "type": "OTHER"
        },
        {
          "name": "Normothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Hours",
        "sex": "ALL",
        "summary": "Up to 6 Hours"
      },
      "enrollment_count": 68,
      "start_date": "2020-05-01",
      "completion_date": "2025-01-31",
      "has_results": false,
      "last_update_posted_date": "2020-03-18",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 5,
      "location_summary": "Loma Linda, California • Oakland, California • Orange, California + 2 more",
      "locations": [
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Oakland",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04176471"
    },
    {
      "nct_id": "NCT00670124",
      "title": "Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Liver Failure",
        "Intracranial Hypertension"
      ],
      "interventions": [
        {
          "name": "Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Rigshospitalet, Denmark",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2005-01",
      "completion_date": "2011-06",
      "has_results": false,
      "last_update_posted_date": "2014-11-05",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00670124"
    },
    {
      "nct_id": "NCT04621279",
      "title": "Cool Prime Comparative Effectiveness Study for Mild HIE",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Hypoxic Ischemic Encephalopathy of Newborn"
      ],
      "interventions": [
        {
          "name": "Normothermia",
          "type": "PROCEDURE"
        },
        {
          "name": "Whole body therapeutic hypothermia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "36 Weeks",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "36 Weeks and older"
      },
      "enrollment_count": 460,
      "start_date": "2023-07-19",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Dallas, Texas",
      "locations": [
        {
          "city": "Dallas",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04621279"
    },
    {
      "nct_id": "NCT01607151",
      "title": "Safety and Feasibility Study of Targeted Temperature Management After ICH",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Intracerebral Hemorrhage"
      ],
      "interventions": [
        {
          "name": "Normothermia",
          "type": "OTHER"
        },
        {
          "name": "Hypothermia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2013-01",
      "completion_date": "2016-06",
      "has_results": false,
      "last_update_posted_date": "2015-08-05",
      "last_synced_at": "2026-09-20T19:37:54.481Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01607151"
    }
  ]
}