{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ACT-128800", "query": { "intervention": "ACT-128800" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 12, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ACT-128800&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-02T21:49:58.919Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02425644", "title": "Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "ponesimod", "type": "DRUG" }, { "name": "teriflunomide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 1133, "start_date": "2015-06-04", "completion_date": "2019-05-16", "has_results": true, "last_update_posted_date": "2025-03-30", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 10, "location_summary": "Carlsbad, California • Pomona, California • Denver, Colorado + 7 more", "locations": [ { "city": "Carlsbad", "state": "California" }, { "city": "Pomona", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Ormond Beach", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02425644" }, { "nct_id": "NCT03232073", "title": "Long-term Extension to Study AC-058B301 to Investigate Safety, Tolerability and Disease Control of Ponesimod 20 mg in Patients With Relapsing Multiple Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "Ponesimod", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 877, "start_date": "2017-07-05", "completion_date": "2024-01-16", "has_results": true, "last_update_posted_date": "2025-06-22", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 9, "location_summary": "Carlsbad, California • Pomona, California • Denver, Colorado + 6 more", "locations": [ { "city": "Carlsbad", "state": "California" }, { "city": "Pomona", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Ormond Beach", "state": "Florida" }, { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03232073" }, { "nct_id": "NCT07686081", "title": "Study to Evaluate the Efficacy and Safety of Ponesimod (VSP-128) in Patients With Moderately to Severely Active Ulcerative Colitis", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Ulcerative Colitis (UC)" ], "interventions": [ { "name": "Ponesimod", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanda Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 150, "start_date": "2026-09", "completion_date": "2029-08", "has_results": false, "last_update_posted_date": "2026-08-18", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 2, "location_summary": "Chula Vista, California • Nashville, Tennessee", "locations": [ { "city": "Chula Vista", "state": "California" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT07686081" }, { "nct_id": "NCT05688436", "title": "A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "Diroximel Fumarate", "type": "DRUG" }, { "name": "Alemtuzumab", "type": "BIOLOGICAL" }, { "name": "Fingolimod", "type": "DRUG" }, { "name": "Glatiramer acetate", "type": "DRUG" }, { "name": "Interferon beta", "type": "BIOLOGICAL" }, { "name": "Natalizumab", "type": "BIOLOGICAL" }, { "name": "Ocrelizumab", "type": "BIOLOGICAL" }, { "name": "Ofatumumab", "type": "BIOLOGICAL" }, { "name": "Ozanimod", "type": "DRUG" }, { "name": "Peginterferon beta-1a", "type": "BIOLOGICAL" }, { "name": "Ponesimod", "type": "DRUG" }, { "name": "Siponimod", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "Biogen", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "49 Years", "sex": "FEMALE", "summary": "18 Years to 49 Years · Female only" }, "enrollment_count": 1178, "start_date": "2021-09-24", "completion_date": "2031-01-17", "has_results": false, "last_update_posted_date": "2026-06-04", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 1, "location_summary": "Eden Prairie, Minnesota", "locations": [ { "city": "Eden Prairie", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT05688436" }, { "nct_id": "NCT01093326", "title": "Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "Ponesimod 10 mg", "type": "DRUG" }, { "name": "Ponesimod 20 mg", "type": "DRUG" }, { "name": "Ponesimod 40 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 353, "start_date": "2010-05-12", "completion_date": "2023-09-06", "has_results": true, "last_update_posted_date": "2025-03-30", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 16, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Palo Alto, California + 13 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Palo Alto", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Venice", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01093326" }, { "nct_id": "NCT03535298", "title": "Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "interventions": [ { "name": "Early Highly Effective Therapies Group", "type": "DRUG" }, { "name": "Escalation Therapies Group", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 800, "start_date": "2019-01-03", "completion_date": "2027-07-30", "has_results": false, "last_update_posted_date": "2026-08-31", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 15, "location_summary": "Aurora, Colorado • Minneapolis, Minnesota • Rochester, Minnesota + 11 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Minneapolis", "state": "Minnesota" }, { "city": "Rochester", "state": "Minnesota" }, { "city": "Las Vegas", "state": "Nevada" }, { "city": "Buffalo", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03535298" }, { "nct_id": "NCT03500328", "title": "Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Multiple Sclerosis, Relapsing-Remitting" ], "interventions": [ { "name": "Natalizumab/natalizumab-sztn, Alemtuzumab, Ocrelizumab, Rituximab/rituximab-arrx/rituximab-abbs/rituximab-pvvr, Cladribine, Ofatumumab, Ublituximab-xiiy, Ocrelizumab and hyaluronidase-ocsq", "type": "OTHER" }, { "name": "Glatiramer acetate, Interferons (intramuscular, subcutaneous, pegylated) Teriflunomide, Fumarates (dimethyl, diroximel, monomethyl) Fingolimod, Siponimod, Ozanimod, Ponesimod", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 900, "start_date": "2018-05-02", "completion_date": "2026-09", "has_results": false, "last_update_posted_date": "2026-09-02", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 47, "location_summary": "Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 38 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Carmichael", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03500328" }, { "nct_id": "NCT01006265", "title": "Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of ACT-128800 in Patients With Relapsing-remitting Multiple Sclerosis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "ACT-128800 Dose 1", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "ACT-128800 Dose 2", "type": "DRUG" }, { "name": "ACT-128800 Dose 3", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 464, "start_date": "2009-10-01", "completion_date": "2011-07-01", "has_results": true, "last_update_posted_date": "2025-03-30", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 25, "location_summary": "Scottsdale, Arizona • Tucson, Arizona • Sacramento, California + 22 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Sacramento", "state": "California" }, { "city": "Stanford", "state": "California" }, { "city": "Sarasota", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01006265" }, { "nct_id": "NCT02907177", "title": "Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Multiple Sclerosis" ], "interventions": [ { "name": "Ponesimod", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 136, "start_date": "2017-03-30", "completion_date": "2020-03-26", "has_results": true, "last_update_posted_date": "2021-05-18", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 26, "location_summary": "Birmingham, Alabama • Fresno, California • Pasadena, California + 22 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Fresno", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "Santa Clarita", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02907177" }, { "nct_id": "NCT02223832", "title": "Study to Evaluate the Pharmacokinetics, Tolerability, and Safety of ACT-128800 in Japanese and Caucasian Healthy Male and Female Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "ACT-128800", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Actelion", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 20, "start_date": "2009-02", "completion_date": "2009-04", "has_results": false, "last_update_posted_date": "2014-08-22", "last_synced_at": "2026-09-02T21:49:58.919Z", "location_count": 1, "location_summary": "Honolulu, Hawaii", "locations": [ { "city": "Honolulu", "state": "Hawaii" } ], "official_url": "https://clinicaltrials.gov/study/NCT02223832" } ] }