{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ALN-PCSSC&page=2", "query": { "intervention": "ALN-PCSSC", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ALN-PCSSC&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-13T10:56:02.075Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06280976", "title": "Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Coronary Artery Disease", "Atherosclerosis", "Heart Attack" ], "interventions": [ { "name": "Statin", "type": "DRUG" }, { "name": "Aspirin tablet", "type": "DRUG" }, { "name": "Nexlizet", "type": "DRUG" }, { "name": "LEQVIO", "type": "DRUG" }, { "name": "Vascepa", "type": "DRUG" }, { "name": "Jardiance", "type": "DRUG" }, { "name": "Colchicine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Louisville", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 0, "start_date": "2024-03-01", "completion_date": "2025-01-01", "has_results": false, "last_update_posted_date": "2025-03-17", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 1, "location_summary": "Louisville, Kentucky", "locations": [ { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT06280976" }, { "nct_id": "NCT05360446", "title": "Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Coronary Artery Disease" ], "interventions": [ { "name": "Inclisiran sodium 300 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 609, "start_date": "2022-07-08", "completion_date": "2026-10-26", "has_results": false, "last_update_posted_date": "2026-07-13", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 27, "location_summary": "Huntsville, Alabama • Anchorage, Alaska • Beverly Hills, California + 22 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Anchorage", "state": "Alaska" }, { "city": "Beverly Hills", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Stanford", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05360446" }, { "nct_id": "NCT07610278", "title": "A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypercholesterolaemia" ], "interventions": [ { "name": "QCZ484", "type": "DRUG" }, { "name": "Inclisiran", "type": "DRUG" }, { "name": "QCZ484 placebo", "type": "DRUG" }, { "name": "Inclisiran placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 120, "start_date": "2026-05-29", "completion_date": "2028-02-03", "has_results": false, "last_update_posted_date": "2026-07-30", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 27, "location_summary": "Foley, Alabama • Saraland, Alabama • Lincoln, California + 24 more", "locations": [ { "city": "Foley", "state": "Alabama" }, { "city": "Saraland", "state": "Alabama" }, { "city": "Lincoln", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Northridge", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07610278" }, { "nct_id": "NCT06813911", "title": "Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Atherosclerotic Cardiovascular Disease (ASCVD)" ], "interventions": [ { "name": "Pelacarsen", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Inclisiran", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 340, "start_date": "2025-04-30", "completion_date": "2028-02-29", "has_results": false, "last_update_posted_date": "2026-08-07", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 35, "location_summary": "Birmingham, Alabama • Sun City West, Arizona • Beverly Hills, California + 31 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Sun City West", "state": "Arizona" }, { "city": "Beverly Hills", "state": "California" }, { "city": "West Hills", "state": "California" }, { "city": "Boca Raton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06813911" }, { "nct_id": "NCT03705234", "title": "A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Atherosclerotic Cardiovascular Disease" ], "interventions": [ { "name": "Inclisiran", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Oxford", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 16124, "start_date": "2018-10-30", "completion_date": "2049-12", "has_results": false, "last_update_posted_date": "2026-05-01", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03705234" }, { "nct_id": "NCT02963311", "title": "A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Homozygous Familial Hypercholesterolemia" ], "interventions": [ { "name": "ALN-PCSSC", "type": "DRUG" }, { "name": "Standard of Care", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Medicines Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 9, "start_date": "2016-12-13", "completion_date": "2018-10-08", "has_results": true, "last_update_posted_date": "2020-05-18", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02963311" }, { "nct_id": "NCT03814187", "title": "Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "ASCVD", "Elevated Cholesterol", "Heterozygous Familial Hypercholesterolemia", "Homozygous Familial Hypercholesterolemia" ], "interventions": [ { "name": "Inclisiran Sodium", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 3275, "start_date": "2019-04-16", "completion_date": "2023-02-13", "has_results": true, "last_update_posted_date": "2024-03-06", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 141, "location_summary": "Birmingham, Alabama • Foley, Alabama • Huntsville, Alabama + 109 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Montgomery", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT03814187" }, { "nct_id": "NCT02597127", "title": "Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Atherosclerotic Cardiovascular Disease", "Familial Hypercholesterolemia", "Diabetes" ], "interventions": [ { "name": "ALN-PCSSC", "type": "DRUG" }, { "name": "Normal Saline", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Medicines Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 501, "start_date": "2016-01", "completion_date": "2017-06-07", "has_results": true, "last_update_posted_date": "2019-05-17", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 8, "location_summary": "Jacksonville, Florida • Indianapolis, Indiana • New York, New York + 4 more", "locations": [ { "city": "Jacksonville", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "New York", "state": "New York" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT02597127" }, { "nct_id": "NCT06597006", "title": "Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Familial Hypercholesterolemia - Homozygous" ], "interventions": [ { "name": "Inclisiran", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 9, "start_date": "2025-02-28", "completion_date": "2029-04-15", "has_results": false, "last_update_posted_date": "2026-07-24", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 4, "location_summary": "San Francisco, California • Washington D.C., District of Columbia • St Louis, Missouri + 1 more", "locations": [ { "city": "San Francisco", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT06597006" }, { "nct_id": "NCT03060577", "title": "An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Atherosclerotic Cardiovascular Disease", "Symptomatic Atherosclerosis", "Type2 Diabetes", "Familial Hypercholesterolemia" ], "interventions": [ { "name": "Inclisiran", "type": "DRUG" }, { "name": "Evolocumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 382, "start_date": "2017-04-27", "completion_date": "2021-12-17", "has_results": true, "last_update_posted_date": "2023-03-24", "last_synced_at": "2026-09-13T10:56:02.075Z", "location_count": 8, "location_summary": "Jacksonville, Florida • Indianapolis, Indiana • New York, New York + 4 more", "locations": [ { "city": "Jacksonville", "state": "Florida" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "New York", "state": "New York" }, { "city": "Cincinnati", "state": "Ohio" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03060577" } ] }