{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=APAP&page=20",
    "query": {
      "intervention": "APAP",
      "page": 20
    },
    "page_size": 10
  },
  "pagination": {
    "page": 20,
    "page_size": 10,
    "total_count": 979,
    "total_pages": 98,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=APAP&page=21&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=APAP&page=19&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-23T13:55:36.135Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05469204",
      "title": "Effect of Estrogen Treatment on Drug Metabolism and Transport",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Transgender Persons"
      ],
      "interventions": [
        {
          "name": "Midazolam oral solution",
          "type": "DRUG"
        },
        {
          "name": "Digoxin Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen Oral Tablet",
          "type": "DRUG"
        },
        {
          "name": "Midazolam Injectable Solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 22,
      "start_date": "2022-11-01",
      "completion_date": "2025-07-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-09",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05469204"
    },
    {
      "nct_id": "NCT05544734",
      "title": "Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Nail Diseases",
        "Nail Abnormality"
      ],
      "interventions": [
        {
          "name": "Hydrocodone 5Mg/Acetaminophen 325Mg Tab",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen 1000mg",
          "type": "DRUG"
        },
        {
          "name": "Ibuprofen 400 mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 20,
      "start_date": "2022-11-10",
      "completion_date": "2023-06-01",
      "has_results": true,
      "last_update_posted_date": "2023-09-28",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05544734"
    },
    {
      "nct_id": "NCT03651804",
      "title": "Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Vertebral Compression Fracture",
        "Facet Joint Pain"
      ],
      "interventions": [
        {
          "name": "Radiofrequency ablation of the medial branch nerves",
          "type": "PROCEDURE"
        },
        {
          "name": "Non-steroidal anti-inflammatory drugs",
          "type": "DRUG"
        },
        {
          "name": "Bisphosphonates",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen",
          "type": "DRUG"
        },
        {
          "name": "Physical therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Opioids",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 0,
      "start_date": "2019-04-10",
      "completion_date": "2023-12-19",
      "has_results": false,
      "last_update_posted_date": "2025-07-16",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "Davis, California",
      "locations": [
        {
          "city": "Davis",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03651804"
    },
    {
      "nct_id": "NCT05919732",
      "title": "Awake Caudal Catheter vs General Anesthesia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Inguinal Hernia"
      ],
      "interventions": [
        {
          "name": "Bupivacaine, Dexmedetomidine, Caffeine, Tylenol",
          "type": "DRUG"
        },
        {
          "name": "Propofol, rocuronium, caffeine, Tylenol, bupivacaine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Nemours Children's Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "60 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 60 Weeks"
      },
      "enrollment_count": 20,
      "start_date": "2016-03-08",
      "completion_date": "2018-03-08",
      "has_results": true,
      "last_update_posted_date": "2024-04-02",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05919732"
    },
    {
      "nct_id": "NCT03974932",
      "title": "Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Analgesia"
      ],
      "interventions": [
        {
          "name": "HTX-011",
          "type": "DRUG"
        },
        {
          "name": "Ibuprofen",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen",
          "type": "DRUG"
        },
        {
          "name": "Celecoxib",
          "type": "DRUG"
        },
        {
          "name": "+/- Bupivacaine HCl",
          "type": "DRUG"
        },
        {
          "name": "Luer Lock Applicator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Heron Therapeutics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 116,
      "start_date": "2019-06-05",
      "completion_date": "2021-01-07",
      "has_results": true,
      "last_update_posted_date": "2026-03-02",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 6,
      "location_summary": "Sheffield, Alabama • Tamarac, Florida • Dayton, Ohio + 3 more",
      "locations": [
        {
          "city": "Sheffield",
          "state": "Alabama"
        },
        {
          "city": "Tamarac",
          "state": "Florida"
        },
        {
          "city": "Dayton",
          "state": "Ohio"
        },
        {
          "city": "Bellaire",
          "state": "Texas"
        },
        {
          "city": "Plano",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03974932"
    },
    {
      "nct_id": "NCT00818493",
      "title": "Pilot Study of the Efficacy and Safety of Q8003 in Patients Who Have Undergone Total Knee Arthroplasty or Total Hip Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Postoperative Pain"
      ],
      "interventions": [
        {
          "name": "Q8003 (morphine sulfate and oxycodone hydrochloride)",
          "type": "DRUG"
        },
        {
          "name": "Low dose Q8003 (morphine sulfate and oxycodone hydrochloride)",
          "type": "DRUG"
        },
        {
          "name": "Percocet (oxycodone and acetaminophen)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "QRxPharma Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 44,
      "start_date": "2009-02",
      "completion_date": "2009-07",
      "has_results": false,
      "last_update_posted_date": "2012-05-17",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 4,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Royal Oak, Michigan + 1 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Royal Oak",
          "state": "Michigan"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00818493"
    },
    {
      "nct_id": "NCT01517295",
      "title": "Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Hydrocodone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NEMA Research, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 30,
      "start_date": "2012-02",
      "completion_date": "2012-09",
      "has_results": true,
      "last_update_posted_date": "2016-07-28",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 2,
      "location_summary": "Naples, Florida • Leawood, Kansas",
      "locations": [
        {
          "city": "Naples",
          "state": "Florida"
        },
        {
          "city": "Leawood",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01517295"
    },
    {
      "nct_id": "NCT04134442",
      "title": "Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Osteoarthritis of the Shoulder",
        "Shoulder Pain",
        "Pain, Postoperative"
      ],
      "interventions": [
        {
          "name": "Bupivacaine Liposome Injection",
          "type": "DRUG"
        },
        {
          "name": "Standard Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of Massachusetts, Worcester",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2019-12-09",
      "completion_date": "2021-09-23",
      "has_results": false,
      "last_update_posted_date": "2022-07-06",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "Worcester, Massachusetts",
      "locations": [
        {
          "city": "Worcester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04134442"
    },
    {
      "nct_id": "NCT07595302",
      "title": "Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pelvic Pain"
      ],
      "interventions": [
        {
          "name": "Acetaminophen 1000mg PO",
          "type": "DRUG"
        },
        {
          "name": "IV Acetaminophen 1000mg",
          "type": "DRUG"
        },
        {
          "name": "IV Placebo",
          "type": "OTHER"
        },
        {
          "name": "PO Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 50 Years · Female only"
      },
      "enrollment_count": 140,
      "start_date": "2026-11",
      "completion_date": "2027-10",
      "has_results": false,
      "last_update_posted_date": "2026-09-23",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07595302"
    },
    {
      "nct_id": "NCT04444830",
      "title": "Sprix for Postoperative Pain Control Following Gynecologic Surgery",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Post Operative Pain Control",
        "Narcotic Use",
        "Pelvic Organ Prolapse",
        "Urinary Incontinence , Stress",
        "Surgery"
      ],
      "interventions": [
        {
          "name": "Sprix",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Louisville",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2021-01",
      "completion_date": "2021-09-21",
      "has_results": false,
      "last_update_posted_date": "2022-07-29",
      "last_synced_at": "2026-10-23T13:55:36.135Z",
      "location_count": 1,
      "location_summary": "Louisville, Kentucky",
      "locations": [
        {
          "city": "Louisville",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04444830"
    }
  ]
}