{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ARDS+and+COVID19+treatments", "query": { "intervention": "ARDS and COVID19 treatments" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 42, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ARDS+and+COVID19+treatments&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-05T14:41:52.464Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03376854", "title": "Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Respiratory Distress Syndrome, Adult", "Sars-CoV2" ], "interventions": [ { "name": "Hypothermia", "type": "DEVICE" }, { "name": "Neuromuscular Blocking Agents", "type": "DRUG" }, { "name": "Standard of Care", "type": "DEVICE" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "University of Maryland, Baltimore", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 0, "start_date": "2018-05-01", "completion_date": "2021-04-27", "has_results": false, "last_update_posted_date": "2021-04-30", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03376854" }, { "nct_id": "NCT04305457", "title": "Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Coronavirus Infections", "Pneumonia, Viral", "Acute Respiratory Distress Syndrome" ], "interventions": [ { "name": "Nitric Oxide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Massachusetts General Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 62, "start_date": "2020-03-21", "completion_date": "2023-08-23", "has_results": true, "last_update_posted_date": "2026-03-23", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 2, "location_summary": "Shreveport, Louisiana • Boston, Massachusetts", "locations": [ { "city": "Shreveport", "state": "Louisiana" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04305457" }, { "nct_id": "NCT04315298", "title": "Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Sarilumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Regeneron Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1912, "start_date": "2020-03-18", "completion_date": "2020-09-02", "has_results": true, "last_update_posted_date": "2021-09-23", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 62, "location_summary": "Los Angeles, California • Sacramento, California • Santa Monica, California + 42 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT04315298" }, { "nct_id": "NCT04842747", "title": "VERU-111 in the Treatment of SARS-Cov-2 Infection by Assessing Its Effect on the Proportion of Patients Who Die on Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "SARS-CoV Infection" ], "interventions": [ { "name": "VERU-111", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Veru Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 204, "start_date": "2021-05-18", "completion_date": "2022-07-06", "has_results": true, "last_update_posted_date": "2026-09-10", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 21, "location_summary": "Scottsdale, Arizona • Jonesboro, Arkansas • Chula Vista, California + 16 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Jonesboro", "state": "Arkansas" }, { "city": "Chula Vista", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04842747" }, { "nct_id": "NCT04367077", "title": "MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "ARDS" ], "interventions": [ { "name": "MultiStem", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Healios K.K.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "89 Years", "sex": "ALL", "summary": "18 Years to 89 Years" }, "enrollment_count": 206, "start_date": "2020-04-28", "completion_date": "2024-10-01", "has_results": false, "last_update_posted_date": "2026-08-11", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 4, "location_summary": "Chicago, Illinois • Akron, Ohio • Cleveland, Ohio", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Akron", "state": "Ohio" }, { "city": "Cleveland", "state": "Ohio" }, { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04367077" }, { "nct_id": "NCT04345601", "title": "Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Sars-CoV2", "Acute Respiratory Distress Syndrome", "COVID-19" ], "interventions": [ { "name": "Mesenchymal Stromal Cells", "type": "BIOLOGICAL" }, { "name": "Supportive Care", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 28, "start_date": "2021-02-12", "completion_date": "2023-01-10", "has_results": true, "last_update_posted_date": "2024-10-09", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04345601" }, { "nct_id": "NCT04488081", "title": "I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19" ], "interventions": [ { "name": "Remdesivir", "type": "DRUG" }, { "name": "Imatinib Mesylate", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Cenicriviroc", "type": "DRUG" }, { "name": "Icatibant", "type": "DRUG" }, { "name": "Apremilast", "type": "DRUG" }, { "name": "dornase alfa", "type": "BIOLOGICAL" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Famotidine", "type": "DRUG" }, { "name": "IC14", "type": "BIOLOGICAL" }, { "name": "Aviptadil", "type": "DRUG" }, { "name": "narsoplimab", "type": "BIOLOGICAL" }, { "name": "Cyproheptadine", "type": "DRUG" }, { "name": "Cyclosporine", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "QuantumLeap Healthcare Collaborative", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1500, "start_date": "2020-07-31", "completion_date": "2030-07-31", "has_results": false, "last_update_posted_date": "2026-03-16", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 36, "location_summary": "Birmingham, Alabama • Davis, California • Irvine, California + 30 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Davis", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04488081" }, { "nct_id": "NCT06729593", "title": "Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Remdesivir", "type": "BIOLOGICAL" }, { "name": "Remdesivir Placebo", "type": "BIOLOGICAL" }, { "name": "Corticosteroid", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 87, "start_date": "2021-04-20", "completion_date": "2022-11-20", "has_results": true, "last_update_posted_date": "2025-10-09", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 40, "location_summary": "Tucson, Arizona • Fresno, California • Loma Linda, California + 28 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06729593" }, { "nct_id": "NCT06729606", "title": "Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Aviptadil", "type": "BIOLOGICAL" }, { "name": "Aviptadil Placebo", "type": "BIOLOGICAL" }, { "name": "Corticosteroid", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 471, "start_date": "2021-04-20", "completion_date": "2022-11-20", "has_results": true, "last_update_posted_date": "2025-10-09", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 40, "location_summary": "Tucson, Arizona • Fresno, California • Loma Linda, California + 28 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Fresno", "state": "California" }, { "city": "Loma Linda", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06729606" }, { "nct_id": "NCT04505592", "title": "Tenecteplase in Patients With COVID-19", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "COVID-19", "Respiratory Failure", "ARDS" ], "interventions": [ { "name": "Tenecteplase", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hooman Poor", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 13, "start_date": "2020-09-25", "completion_date": "2022-03-10", "has_results": true, "last_update_posted_date": "2023-04-06", "last_synced_at": "2026-10-05T14:41:52.464Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT04505592" } ] }