{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Acetaminophen+rescue+medication", "query": { "intervention": "Acetaminophen rescue medication" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 48, "total_pages": 5, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Acetaminophen+rescue+medication&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-21T08:56:10.065Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07348627", "title": "Opioid-Sparing Joint Replacement", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain Management", "Opioid Consumption" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Oxycodone 5 mg", "type": "DRUG" }, { "name": "Multimodal Non-Opioid Analgesia", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 120, "start_date": "2026-03-19", "completion_date": "2028-08", "has_results": false, "last_update_posted_date": "2026-04-17", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT07348627" }, { "nct_id": "NCT01608308", "title": "Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Chronic Sinusitis" ], "interventions": [ { "name": "IV Acetaminophen", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "68 Years", "sex": "ALL", "summary": "18 Years to 68 Years" }, "enrollment_count": 62, "start_date": "2012-07", "completion_date": "2014-09", "has_results": true, "last_update_posted_date": "2015-10-16", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01608308" }, { "nct_id": "NCT05919745", "title": "Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain, Post Operative", "Quality of Life" ], "interventions": [ { "name": "Ibuprofen 600 mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Marquette University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 50, "start_date": "2023-10-19", "completion_date": "2026-12", "has_results": false, "last_update_posted_date": "2024-09-27", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Milwaukee, Wisconsin", "locations": [ { "city": "Milwaukee", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT05919745" }, { "nct_id": "NCT03822962", "title": "Pain Management Following Sinus Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Nasal Sinus; Inflammation", "Opioid Abuse", "Pain, Postoperative" ], "interventions": [ { "name": "Ibuprofen 600Mg Tablet", "type": "DRUG" }, { "name": "Standard Regimen | Tylenol", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Nebraska", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 10, "start_date": "2020-11-07", "completion_date": "2023-05-30", "has_results": false, "last_update_posted_date": "2023-09-06", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 2, "location_summary": "Omaha, Nebraska • Cincinnati, Ohio", "locations": [ { "city": "Omaha", "state": "Nebraska" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03822962" }, { "nct_id": "NCT06780111", "title": "Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Esophageal Squamous Cell Carcinoma" ], "interventions": [ { "name": "Pembrolizumab", "type": "BIOLOGICAL" }, { "name": "I-DXd", "type": "BIOLOGICAL" }, { "name": "Leucovorin", "type": "DRUG" }, { "name": "Levoleucovorin", "type": "DRUG" }, { "name": "5-Fluorouracil (5-FU)", "type": "DRUG" }, { "name": "Oxaliplatin", "type": "DRUG" }, { "name": "Sacituzumab tirumotecan", "type": "BIOLOGICAL" }, { "name": "Rescue Medication", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 298, "start_date": "2025-07-30", "completion_date": "2032-01-04", "has_results": false, "last_update_posted_date": "2026-09-17", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06780111" }, { "nct_id": "NCT05279898", "title": "Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Delirium", "Hemodynamic Instability", "Pain", "Neurocognitive Dysfunction" ], "interventions": [ { "name": "EEG Monitoring", "type": "DEVICE" }, { "name": "Ropivacaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Remifentanil", "type": "DRUG" }, { "name": "Dexmedetomidine", "type": "DRUG" }, { "name": "Rocuronium", "type": "DRUG" }, { "name": "Propofol", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Beth Israel Deaconess Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 70, "start_date": "2023-02-28", "completion_date": "2024-12-31", "has_results": true, "last_update_posted_date": "2025-11-26", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05279898" }, { "nct_id": "NCT05405166", "title": "SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Plasma Cell Myeloma Recurrent" ], "interventions": [ { "name": "Isatuximab IV", "type": "DRUG" }, { "name": "Isatuximab SC", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Pomalidomide", "type": "DRUG" }, { "name": "Montelukast", "type": "DRUG" }, { "name": "Paracetamol / Acetaminophen", "type": "DRUG" }, { "name": "Diphenhydramine", "type": "DRUG" }, { "name": "Methylprednisolone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 531, "start_date": "2022-06-23", "completion_date": "2027-10-22", "has_results": true, "last_update_posted_date": "2026-09-02", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 13, "location_summary": "Aurora, Colorado • Jacksonville, Florida • Plantation, Florida + 10 more", "locations": [ { "city": "Aurora", "state": "Colorado" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Plantation", "state": "Florida" }, { "city": "Hattiesburg", "state": "Mississippi" }, { "city": "Morristown", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05405166" }, { "nct_id": "NCT05200806", "title": "A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Analgesia", "Post-Operative Pain", "Breakthrough Pain", "Colectomy" ], "interventions": [ { "name": "Non-Narcotic ERAS Post-Operative Pain Management", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of Vermont", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 25, "start_date": "2022-02-07", "completion_date": "2024-10", "has_results": false, "last_update_posted_date": "2022-10-14", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 1, "location_summary": "Burlington, Vermont", "locations": [ { "city": "Burlington", "state": "Vermont" } ], "official_url": "https://clinicaltrials.gov/study/NCT05200806" }, { "nct_id": "NCT06973785", "title": "Non-Narcotic Pain Control After ACL Reconstruction", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "ACL - Anterior Cruciate Ligament Rupture", "ACL Injuries" ], "interventions": [ { "name": "dispense of study drug", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "15 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "15 Years to 55 Years" }, "enrollment_count": 30, "start_date": "2025-07-15", "completion_date": "2027-06-15", "has_results": false, "last_update_posted_date": "2026-08-24", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 3, "location_summary": "Coral Springs, Florida • Garfield, Ohio • Strongsville, Ohio", "locations": [ { "city": "Coral Springs", "state": "Florida" }, { "city": "Garfield", "state": "Ohio" }, { "city": "Strongsville", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT06973785" }, { "nct_id": "NCT06312137", "title": "A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Non Small Cell Lung Cancer" ], "interventions": [ { "name": "Sacituzumab tirumotecan", "type": "BIOLOGICAL" }, { "name": "Pembrolizumab", "type": "BIOLOGICAL" }, { "name": "Cisplatin", "type": "DRUG" }, { "name": "Pemetrexed", "type": "DRUG" }, { "name": "Gemcitabine", "type": "DRUG" }, { "name": "Carboplatin", "type": "DRUG" }, { "name": "Paclitaxel", "type": "DRUG" }, { "name": "Rescue medication", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 780, "start_date": "2024-04-03", "completion_date": "2034-10-23", "has_results": false, "last_update_posted_date": "2026-09-17", "last_synced_at": "2026-09-21T08:56:10.065Z", "location_count": 51, "location_summary": "Little Rock, Arkansas • Springdale, Arkansas • Beverly Hills, California + 41 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Springdale", "state": "Arkansas" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06312137" } ] }