{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ampreloxetine+Placebo", "query": { "intervention": "Ampreloxetine Placebo" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 6, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-27T05:28:57.480Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03750552", "title": "Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypotension" ], "interventions": [ { "name": "ampreloxetine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 195, "start_date": "2019-01-24", "completion_date": "2021-07-21", "has_results": true, "last_update_posted_date": "2022-09-14", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 23, "location_summary": "Sun City, Arizona • Long Beach, California • Palo Alto, California + 19 more", "locations": [ { "city": "Sun City", "state": "Arizona" }, { "city": "Long Beach", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Loveland", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03750552" }, { "nct_id": "NCT04688632", "title": "Thorough QT Study to Evaluate Ampreloxetine in Healthy Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypertension", "nOH" ], "interventions": [ { "name": "Ampreloxetine ", "type": "DRUG" }, { "name": "Ampreloxetine ", "type": "DRUG" }, { "name": "Ampreloxetine Placebo", "type": "DRUG" }, { "name": "Moxifloxacin", "type": "DRUG" }, { "name": "Moxifloxacin Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 72, "start_date": "2021-01-18", "completion_date": "2021-03-26", "has_results": false, "last_update_posted_date": "2021-04-20", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 1, "location_summary": "Tempe, Arizona", "locations": [ { "city": "Tempe", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT04688632" }, { "nct_id": "NCT05696717", "title": "Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypotension", "MSA - Multiple System Atrophy" ], "interventions": [ { "name": "Ampreloxetine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 102, "start_date": "2023-06-27", "completion_date": "2028-01", "has_results": false, "last_update_posted_date": "2025-09-05", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 26, "location_summary": "Scottsdale, Arizona • Fountain Valley, California • La Jolla, California + 21 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Fountain Valley", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05696717" }, { "nct_id": "NCT02705755", "title": "TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Neurogenic Orthostatic Hypotension", "Multiple System Atrophy (MSA) With Orthostatic Hypotension", "Pure Autonomic Failure", "Parkinson Disease", "Hypotension, Orthostatic", "Orthostatic Hypotension", "Pure Autonomic Failure With Orthostatic Hypotension", "Parkinson Disease With Orthostatic Hypotension" ], "interventions": [ { "name": "TD-9855", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": null, "sex": "ALL", "summary": "40 Years and older" }, "enrollment_count": 34, "start_date": "2017-09-09", "completion_date": "2018-11-28", "has_results": true, "last_update_posted_date": "2022-09-26", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 6, "location_summary": "Long Beach, California • Farmington Hills, Michigan • Berlin, New Jersey + 3 more", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Farmington Hills", "state": "Michigan" }, { "city": "Berlin", "state": "New Jersey" }, { "city": "New York", "state": "New York" }, { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02705755" }, { "nct_id": "NCT03829657", "title": "Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Symptomatic Neurogenic Orthostatic Hypotension", "MSA", "Parkinson's Disease (PD)", "Pure Autonomic Failure (PAF)" ], "interventions": [ { "name": "ampreloxetine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 203, "start_date": "2019-02-22", "completion_date": "2021-11-10", "has_results": true, "last_update_posted_date": "2023-01-20", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 20, "location_summary": "Sun City, Arizona • La Jolla, California • Palo Alto, California + 16 more", "locations": [ { "city": "Sun City", "state": "Arizona" }, { "city": "La Jolla", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Boca Raton", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03829657" }, { "nct_id": "NCT01458340", "title": "A Study of TD-9855 in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Attention-Deficit/Hyperactivity Disorder", "ADHD" ], "interventions": [ { "name": "TD-9855", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Theravance Biopharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 295, "start_date": "2011-12", "completion_date": "2013-11", "has_results": true, "last_update_posted_date": "2022-04-04", "last_synced_at": "2026-09-27T05:28:57.480Z", "location_count": 17, "location_summary": "Bradenton, Florida • Jacksonville, Florida • Maitland, Florida + 13 more", "locations": [ { "city": "Bradenton", "state": "Florida" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Maitland", "state": "Florida" }, { "city": "Palm Beach", "state": "Florida" }, { "city": "Smyrna", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01458340" } ] }