{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ankle+manipulation&page=2",
    "query": {
      "intervention": "Ankle manipulation",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ankle+manipulation&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-27T16:08:26.794Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01314183",
      "title": "Enhancing the Effectiveness of Physical Therapy for People With Knee Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Exercise",
          "type": "OTHER"
        },
        {
          "name": "manual therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Agency for Healthcare Research and Quality (AHRQ)",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2011-04",
      "completion_date": "2015-04",
      "has_results": false,
      "last_update_posted_date": "2015-06-23",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 3,
      "location_summary": "Pittsburgh, Pennsylvania • San Antonio, Texas • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01314183"
    },
    {
      "nct_id": "NCT02233140",
      "title": "Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetes",
        "Equinus Contracture of the Ankle"
      ],
      "interventions": [
        {
          "name": "Extra-corporeal pulsed-activated therapy or shockwave therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Temple University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 48,
      "start_date": "2014-10",
      "completion_date": "2017-10",
      "has_results": false,
      "last_update_posted_date": "2015-08-27",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02233140"
    },
    {
      "nct_id": "NCT00847769",
      "title": "Ankle Sprains and Corticospinal Excitability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Ankle Sprain"
      ],
      "interventions": [
        {
          "name": "High velocity, low amplitude stretch",
          "type": "OTHER"
        },
        {
          "name": "Slow, mobilization stretch",
          "type": "OTHER"
        },
        {
          "name": "Passive Positioning",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 27,
      "start_date": "2008-12",
      "completion_date": "2011-08",
      "has_results": false,
      "last_update_posted_date": "2017-04-04",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00847769"
    },
    {
      "nct_id": "NCT03731767",
      "title": "The Effect of a Talocrural Thrust Manipulation on Lateral Ankle Ligament Integrity in a Subgroup of Healthy Individuals",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy"
      ],
      "interventions": [
        {
          "name": "Distraction thrust manipulation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Florida Gulf Coast University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 50,
      "start_date": "2018-10-20",
      "completion_date": "2019-08-01",
      "has_results": false,
      "last_update_posted_date": "2020-07-22",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Cape Coral, Florida",
      "locations": [
        {
          "city": "Cape Coral",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03731767"
    },
    {
      "nct_id": "NCT03428620",
      "title": "Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains"
      ],
      "interventions": [
        {
          "name": "High Velocity Low Amplitude mobilization",
          "type": "OTHER"
        },
        {
          "name": "Exercise protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shenandoah University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 50,
      "start_date": "2018-02-14",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2018-04-17",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 2,
      "location_summary": "Fayetteville, North Carolina • Winchester, Virginia",
      "locations": [
        {
          "city": "Fayetteville",
          "state": "North Carolina"
        },
        {
          "city": "Winchester",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03428620"
    },
    {
      "nct_id": "NCT01541657",
      "title": "Sensory-Targeted Ankle Rehabilitation Strategies (STARS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Ankle Instability"
      ],
      "interventions": [
        {
          "name": "Ankle Joint Mobilization",
          "type": "OTHER"
        },
        {
          "name": "Foot Massage",
          "type": "OTHER"
        },
        {
          "name": "Calf Stretching",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Joel Thompson",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 80,
      "start_date": "2011-12",
      "completion_date": "2014-04",
      "has_results": false,
      "last_update_posted_date": "2018-01-26",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 2,
      "location_summary": "Ithaca, New York • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Ithaca",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01541657"
    },
    {
      "nct_id": "NCT06858592",
      "title": "Osteopathic Manipulative Techniques in Collegiate Dancers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteopathic Manipulative Treatment (OMT)",
        "Dance Therapy"
      ],
      "interventions": [
        {
          "name": "Osteopathic Manipulative Treatment (OMT)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Edward Via Virginia College of Osteopathic Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 15,
      "start_date": "2025-02-01",
      "completion_date": "2025-02-22",
      "has_results": false,
      "last_update_posted_date": "2025-03-05",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Monroe, Louisiana",
      "locations": [
        {
          "city": "Monroe",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06858592"
    },
    {
      "nct_id": "NCT06546462",
      "title": "Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders?",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Headache Disorders",
        "Headache",
        "Analgesia",
        "Opioid Use",
        "Osteopathy"
      ],
      "interventions": [
        {
          "name": "Osteopathic Manipulative Treatment (OMT)",
          "type": "OTHER"
        },
        {
          "name": "Sham Light touch arm",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "New York Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-04-08",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-03-17",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Old Westbury, New York",
      "locations": [
        {
          "city": "Old Westbury",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06546462"
    },
    {
      "nct_id": "NCT03918473",
      "title": "Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains"
      ],
      "interventions": [
        {
          "name": "Mobilization with Movement",
          "type": "OTHER"
        },
        {
          "name": "Thrust Mobilization",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shenandoah University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 50,
      "start_date": "2019-04",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2019-04-17",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Winchester, Virginia",
      "locations": [
        {
          "city": "Winchester",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03918473"
    },
    {
      "nct_id": "NCT00523172",
      "title": "Clinical Assessment of Two Manipulative Protocols in Treatment of Hip Osteoarthritis",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Osteoarthritis, Hip"
      ],
      "interventions": [
        {
          "name": "manual or manipulative therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Manual / Manipulative Therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Supportive Care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Cleveland Chiropractic College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "40 Years to 85 Years"
      },
      "enrollment_count": 120,
      "start_date": "2007-10",
      "completion_date": "2010-10",
      "has_results": false,
      "last_update_posted_date": "2010-07-19",
      "last_synced_at": "2026-09-27T16:08:26.794Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00523172"
    }
  ]
}