{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Application+of+positive-end-expiratory+pressure", "query": { "intervention": "Application of positive-end-expiratory pressure" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-27T22:00:03.788Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05440851", "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Insufficiency", "Extracorporeal Membrane Oxygenation Complication", "Mechanical Ventilation Pressure High" ], "interventions": [ { "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support", "type": "OTHER" }, { "name": "Lung-Protective Ventilation (LPV)", "type": "OTHER" }, { "name": "Driving Pressure-Limited Ventilation (DPL)", "type": "OTHER" }, { "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)", "type": "OTHER" }, { "name": "Early Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Extended Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Usual care without routine corticosteroids", "type": "DRUG" }, { "name": "Usual care without extending corticosteroids", "type": "DRUG" }, { "name": "Usual care with fludrocortisone", "type": "DRUG" }, { "name": "Usual care without fludrocortisone", "type": "DRUG" }, { "name": "Drug 4 mL:", "type": "DRUG" }, { "name": "Drug 40 mg:", "type": "DRUG" }, { "name": "PEEP-20", "type": "OTHER" }, { "name": "PEEP-AOP", "type": "OTHER" }, { "name": "PEEP-10", "type": "OTHER" }, { "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation", "type": "OTHER" }, { "name": "Electrical impedance tomography (EIT)", "type": "OTHER" }, { "name": "no treatment / intervention arm is involved.", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Early Routine IMT", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "University Health Network, Toronto", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6250, "start_date": "2023-04-30", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-05-07", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 26, "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05440851" }, { "nct_id": "NCT01471431", "title": "Extubation Readiness Study in Very Low Birthweight Infants", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Distress Syndrome" ], "interventions": [ { "name": "spontaneous breathing trial", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "48 Hours", "maximum_age": "14 Weeks", "sex": "ALL", "summary": "48 Hours to 14 Weeks" }, "enrollment_count": 81, "start_date": "2011-08", "completion_date": "2016-04", "has_results": false, "last_update_posted_date": "2016-06-07", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 2, "location_summary": "Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania", "locations": [ { "city": "Phialdelphia", "state": "Pennsylvania" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01471431" }, { "nct_id": "NCT02323009", "title": "Esophageal Balloon Guided Weaning of the Morbidly Obese Patient", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Morbid Obesity" ], "interventions": [ { "name": "Esophageal Balloon", "type": "DEVICE" }, { "name": "Cstat", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "East Carolina University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 25, "start_date": "2011-01", "completion_date": "2013-11", "has_results": false, "last_update_posted_date": "2014-12-23", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 1, "location_summary": "Greenville, North Carolina", "locations": [ { "city": "Greenville", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT02323009" }, { "nct_id": "NCT07019987", "title": "Adiposity Distribution in Acute Respiratory Failure", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acute Hypoxemic Respiratory Failure", "Obesity" ], "interventions": [ { "name": "PEEP Titration Using Electrical Impedance Tomography (EIT)", "type": "OTHER" }, { "name": "Body Positioning: Supine and Prone", "type": "PROCEDURE" } ], "intervention_types": [ "OTHER", "PROCEDURE" ], "sponsor": "Maurizio F. Cereda, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 80, "start_date": "2028-01-01", "completion_date": "2030-06-30", "has_results": false, "last_update_posted_date": "2025-06-13", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT07019987" }, { "nct_id": "NCT01672242", "title": "Assessment of End Expiratory Lung Volumes in Healthy Subjects Using High Flow Oxygen (Vapotherm®)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Healthy Adult Volunteers" ], "interventions": [ { "name": "HFNC", "type": "DEVICE" }, { "name": "CPAP", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Maryland, Baltimore", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 6, "start_date": "2012-07", "completion_date": "2014-04", "has_results": true, "last_update_posted_date": "2022-03-08", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01672242" }, { "nct_id": "NCT04372953", "title": "Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lung Injury", "Preterm Birth" ], "interventions": [ { "name": "Positive End-Expiratory Pressure (PEEP)", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Murdoch Childrens Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "23 Weeks", "maximum_age": "28 Weeks", "sex": "ALL", "summary": "23 Weeks to 28 Weeks" }, "enrollment_count": 906, "start_date": "2021-05-04", "completion_date": "2028-05-30", "has_results": false, "last_update_posted_date": "2026-02-19", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 4, "location_summary": "Little Rock, Arkansas • San Diego, California • Indianapolis, Indiana + 1 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Indianapolis", "state": "Indiana" }, { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04372953" }, { "nct_id": "NCT04912583", "title": "Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Spinal Cord Injuries" ], "interventions": [ { "name": "High tidal volume", "type": "DEVICE" }, { "name": "Low tidal volume", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 31, "start_date": "2021-12-17", "completion_date": "2024-06-27", "has_results": true, "last_update_posted_date": "2025-07-15", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 2, "location_summary": "Englewood, Colorado • Houston, Texas", "locations": [ { "city": "Englewood", "state": "Colorado" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04912583" }, { "nct_id": "NCT01188473", "title": "Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Status Asthmaticus" ], "interventions": [ { "name": "NPPV plus standard of care", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Southern Illinois University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Year to 18 Years" }, "enrollment_count": 0, "start_date": "2009-01", "completion_date": "2010-01", "has_results": false, "last_update_posted_date": "2014-12-19", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 1, "location_summary": "Springfield, Illinois", "locations": [ { "city": "Springfield", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01188473" }, { "nct_id": "NCT06229886", "title": "Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Tricuspid Regurgitation", "Mechanical Ventilation Pressure High", "Pediatric Respiratory Diseases" ], "interventions": [ { "name": "Application of positive-end-expiratory pressure", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Northwell Health", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "3 Months", "maximum_age": "18 Years", "sex": "ALL", "summary": "3 Months to 18 Years" }, "enrollment_count": 20, "start_date": "2023-12-06", "completion_date": "2024-09-21", "has_results": false, "last_update_posted_date": "2024-09-26", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 1, "location_summary": "New Hyde Park, New York", "locations": [ { "city": "New Hyde Park", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06229886" }, { "nct_id": "NCT06066502", "title": "Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Respiratory Distress Syndrome", "Respiratory Failure" ], "interventions": [ { "name": "Precision ventilation", "type": "OTHER" }, { "name": "Guided usual care ventilation", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Beth Israel Deaconess Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1100, "start_date": "2024-06-24", "completion_date": "2030-12-31", "has_results": false, "last_update_posted_date": "2026-06-29", "last_synced_at": "2026-09-27T22:00:03.788Z", "location_count": 33, "location_summary": "Tucson, Arizona • Little Rock, Arkansas • La Jolla, California + 25 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "La Jolla", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06066502" } ] }